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Publications associées (22)

Evaluation of antigravitational support levels provided by a passive upper-limb occupational exoskeleton in repetitive arm movements

Giulia Ramella

Upper-limb occupational exoskeletons to support the workers' upper arms are typically designed to provide antigravitational support. Although typical work activities require workers to perform static and dynamic actions, the majority of the studies in lite ...

Elsevier Sci Ltd2024

Mitophagy Activation by Urolithin A to Target Muscle Aging

Davide D'Amico

The age-related loss of skeletal muscle function starts from midlife and if left unaddressed can lead to an impaired quality of life. A growing body of evidence indicates that mitochondrial dysfunction is causally involved with muscle aging. Muscles are ti ...

Springer2023

Improving hand prosthesis control with advanced single-finger proportional decoding and robotic shared control

Vincent Alexandre Mendez

Myoelectric prostheses allow users to recover lost functionality by controlling a robotic device with their remaining muscle activity. Commercial devices usually use a two-recording-channel system placed on specific muscles to control a single degree of fr ...

EPFL2023

REM sleep and muscle atonia in brainstem stroke: A quantitative polysomnographic and lesion analysis study

Lukas Heydrich, Eva Blondiaux

Important brainstem regions are involved in the regulation of rapid eye movement sleep. We hypothesized that brainstem stroke is associated with dysregulated rapid eye movement sleep and related muscle activity. We compared quantitative/qualitative polysom ...

WILEY2022

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

Sara Ancel

Muscle stem cells (MuSCs) are the primary source of myogenic progenitors during muscle repair and are essential for the long-term regenerative capacity of skeletal muscle. Following myofiber injury, MuSCs transition from a quiescent to an activated state, ...

EPFL2022

Detection of movement onset using EMG signals for upper-limb exoskeletons in reaching tasks

Silvestro Micera

BackgroundTo assist people with disabilities, exoskeletons must be provided with human-robot interfaces and smart algorithms capable to identify the user's movement intentions. Surface electromyographic (sEMG) signals could be suitable for this purpose, bu ...

BioMed Central2019

Towards an Adaptive Upper Limb Rehabilitation Game with Tangible Robots

Pierre Dillenbourg, Friedhelm Christoph Hummel, Wafa Monia Benkaouar Johal, Maximilian Jonas Wessel, Arzu Güneysu Özgür, Ayberk Özgür, Pablo Maceira Elvira, Louis Pierre Faucon, Andéol Geoffroy Cadic-Melchior

A key feature of a successful game is its ability to provide the player with an adequate level of challenge. However, the objective of difficulty adaptation in serious games is not only to maintain the player’s motivation by challenging, but also to ensure ...

2019

Shared human–robot proportional control of a dexterous myoelectric prosthesis

Aude Billard, Silvestro Micera, Fiorenzo Artoni, Francesco Maria Petrini, Edoardo D'Anna, Nicolas Sommer, Vincent Alexandre Mendez, Emanuele Formento, Katie Zhi Zhuang, Saurav Aryan

Myoelectric prostheses allow users to recover lost functionality by controlling a robotic device with their remaining muscle activity. Such commercial devices can give users a high level of autonomy, but still do not approach the dexterity of the intact hu ...

2019

Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice

Pierre Magistretti, Sylvain Eric Lengacher

The purpose of this study was to investigate the effects of a partial suppression of monocarboxylate transporter (MCT)-1 on skeletalmuscle pH, energetics, and function (MCT1(+/-) mice). Twenty-fourMCT1(+/-) and 13 wild-type (WT) mice were subjected to a re ...

Federation of American Society of Experimental Biology2017

Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion

Daniel Constam, Olivier Andreas Dubey, Susanna Eveliina Kallioinen

The secreted growth factor Activin-A of the transforming growth factor beta family and its receptors can promote or inhibit several cancer hallmarks including tumor cell proliferation and differentiation, vascularization, lymphangiogenesis and inflammation ...

2017

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Johan Auwerx, Maria del Carmen Sandi Perez, Patrick Aebischer, Laurent Mouchiroud, Evan Graehl Williams, Dongryeol Ryu, Pénélope Andreux, Elena Katsyuba, Pooja Jha, Damien Sébastien Huzard, Giuseppe Lo Sasso, Norman Lionel Moullan

The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We ...

2016

Muscle activation variability is inversely correlated with walking speed

Auke Ijspeert, Florin Dzeladini

Individuals with motor impairments typically walk at much slower speeds than their unimpaired counter- parts, yet their gait data is still evaluated against the relatively faster gait of healthy subjects. Therefore a good understanding of unimpaired gait a ...

Springer2016

Gd(DOTAlaP): Exploring the Boundaries of Fast Water Exchange in Gadolinium-Based Magnetic Resonance Imaging Contrast Agents

Lothar Helm, Shima Karimi

Here, we describe the synthesis of the single amino acid chelator DOTAlaP and four of its derivatives. The corresponding gadolinium(III) complexes were investigated for their kinetic inertness, relaxometric properties at a range of fields and temperatures, ...

American Chemical Society2014

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

Boris Hinz, Adriano Garonna, Lysianne Follonier Castella

Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix. We pro ...

Public Library Science2013

Comparing localized and nonlocalized dynamic 31P magnetic resonance spectroscopy in exercising muscle at 7T

Christine Nabuurs

By improving spatial and anatomical specificity, localized spectroscopy can enhance the power and accuracy of the quantitative analysis of cellular metabolism and bioenergetics. Localized and nonlocalized dynamic 31P magnetic resonance spectroscopy using a ...

Wiley-Blackwell2012

Phosphocreatine line with changes in localised 31P MRS of exercising muscle at 7T

Rolf Gruetter, Christine Nabuurs

The aim was to investigate changes in the line width of high-energy phosphates solely originating from the intramyocellular compartment by temporally resolved localised 31P-MRS after aerobic calf muscle exercise. Semi-Laser [2] localised 31P-MRS of gastroc ...

2011

Active strain and activation models in cardiac electromechanics

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Simone Rossi

We present a model for mechanical activation of the cardiac tissue depending on the evolution of the transmembrane electrical potential and certain gating/ionic variables that are available in most of electrophysiological descriptions of the cardiac membra ...

2011

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Evan Graehl Williams, Hiroyasu Yamamoto

Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enha ...

2011

A New Lock-step Mechanism of Matrix Remodelling Based on Subcellular Contractile Events

Boris Hinz, Jean-Jacques Meister, Lara Buscemi Estefanell, Lysianne Follonier Castella

Myofibroblasts promote tissue contractures during fibrotic diseases. To understand how spontaneous changes in the intracellular calcium concentration, Ca2+, contribute to myofibroblast contraction, we analysed both Ca2+ and subcellular contractio ...

Company of Biologists2010

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

Johan Auwerx, Carlos Canto Alvarez, Chikage Mataki

During fasting and after exercise, skeletal muscle efficiently switches from carbohydrate to lipid as the main energy source to preserve glycogen stores and blood glucose levels for glucose-dependent tissues. Skeletal muscle cells sense this limitation in ...

Cell Press2010