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Concept

Résolution chirale

Publications associées (25)

Hard X-ray helical dichroism of disordered molecular media

Majed Chergui, Giulia Fulvia Mancini, Malte Oppermann, Oliviero Cannelli, Dominik Kinschel, Camila Bacellar Cases Da Silveira

Chirality is a structural property of molecules lacking mirror symmetry that has strong implications in diverse fields, ranging from life sciences to materials science. Chirality-sensitive spectroscopic methods, such as circular dichroism, exhibit weak sig ...

Nature Publishing Group2022

Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols

Xile Hu, Zhikun Zhang

Deracemization of racemic chiral compounds is an attractive approach in asymmetric synthesis, but its development has been hindered by energetic and kinetic challenges. Here we describe a catalytic deracemization method for secondary benzylic alcohols whic ...

Wiley-VCH Verlag GmbH2021

Observation of a singular Weyl point surrounded by charged nodal walls in PtGa

Oleg Yazyev, Jan Hugo Dil, Quansheng Wu, Shengnan Zhang

Constrained by the Nielsen-Ninomiya no-go theorem, in all so-far experimentally determined Weyl semimetals (WSMs) the Weyl points (WPs) always appear in pairs in the momentum space with no exception. As a consequence, Fermi arcs occur on surfaces which con ...

Nature Research2021

Schiff base ligands derived from 1,2-bis(2 '-nitro-/amino-phenoxy)-3-R-benzene and 2-hydroxy-1-naphthaldehyde and their Cu/Zn(II) complexes: synthesis, characterization, X-ray structures and computational studies

Rosario Scopelliti

1,2-Bis(2'-nitrophenoxy)-3-R-benzenes {R = H (1), CH3 (2) and OCH3 (3)} have been prepared from the S-N-Ar reaction between 1-fluoro-2-nitrobenzene and 3-R-catechol (aromatic diol), and are then reduced to the corresponding diamines 1,2-bis(2'-aminophenoxy ...

ROYAL SOC CHEMISTRY2021

Discrete metal nanoparticles with plasmonic chirality

Jijun He

From a geometrical perspective, a chiral object does not have mirror planes or inversion symmetry. It exhibits the same physical properties as its mirror image (enantiomer), except for the chiroptical activity, which is often the opposite. Recent advanceme ...

Royal Society of Chemistry2021

Chiral Cyclopentadienyl Ligands: Design, Syntheses, and Applications in Asymmetric Catalysis

Nicolai Cramer, Benoît Daniel Bertrand Audic, Josep Más-Roselló, Aragorn Nathan Laverny, Ana Garcia Herraiz

The creation of new chiral ligands capable of providing high stereocontrol in metal-catalyzed reactions is crucial in modern organic synthesis. The production of bioactive molecules as single enantiomers is increasingly required, and asymmetric catalysis w ...

Wiley-VCH Verlag GmbH2021

Solid-state to solution helicity inversion of pseudotetrahedral chiral copper(II) complexes with 2,4-dihalo-salicylaldiminate ligands

Rosario Scopelliti

The enantiopure Schiff bases (R or S)-N-1-( phenyl)ethyl-2,4-X-1,X2(-)salicylaldimine (X-1, X-2 = Cl, Br, I) coordinate to copper(II) and provide pseudotetrahedral bis[(S or R)-N-1-(phenyl)ethyl-(2,4-X-1,X-2-salicylaldiminato.2N,O)]-./.-Cu(II) (kappa N-2,O ...

ROYAL SOC CHEMISTRY2020

A Subwavelength Microwave Bandpass Filter Based on a Chiral Waveguide

Romain Christophe Rémy Fleury, Maliheh Khatibi Moghaddam

Wave manipulation at a subwavelength scale has recently attracted significant interest, especially for low-frequency wave propagation, from acoustic to microwave devices. Recently, a few methods achieving subwavelength routing using locally resonant metama ...

IEEE Xplore2020

A Short Synthesis of the 2-Bromo-N,9-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-6-amine Building Block

Andrea Pfeifer

A concise synthesis of pharmaceutically useful (R)-tert-butyl N-(2-bromo-9-methyl-6,7,8,9-tetrahydro-5H-pyrido [2,3-b ] indol-6-yl) -N-methylcarbamate building block 11 is described. The racemic intermediate 17 was prepared in a single step from 2-bromo-6- ...

AMER CHEMICAL SOC2019

Accessible Superchiral Near-Fields Driven by Tailored Electric and Magnetic Resonances in All-Dielectric Nanostructures

Hatice Altug, Andreas Tittl, Yasaman Jahani, Kosmas Tsakmakidis, Ershad Mohammadi

Detection and differentiation of enantiomers in small quantities are crucially important in many scientific fields, including biology, chemistry, and pharmacy. Chiral molecules manifest their handedness in their interaction with the chiral state of light ( ...

AMER CHEMICAL SOC2019

Interplay of H-Bonds with Aromatics in Isolated Complexes Identifies Isomeric Carbohydrates

Oleg Boyarkine, Vladimir Kopysov, Aleksandr Pereverzev, Ruslan Yamaletdinov

The tremendous isomeric diversity of carbohydrates enables a wide range of their biological functions but makes the identification and study of these molecules difficult. We investigated the ability of intermolecular interactions to communicate structural ...

Wiley-VCH Verlag GmbH2019

Subwavelength robust waveguiding with chiral metamaterial waveguides

Romain Christophe Rémy Fleury, Bakhtiyar Orazbayev, Nadège Sihame Kaïna

In this work, we design and experimentally demonstrate in the microwave range a robust metamaterial waveguide, which is formed at the boundary between two locally resonant chiral metamaterials with opposite chirality. We show that the interface states at s ...

IEEE2019

Development of Catalytic Asymmetric C-H Functionalizations with Chiral Cyclopentadienyl Iridium(III) Complexes

Yun-Suk Jang

Cp*Ir(III) catalyzed C-H functionalization is a growing field, since it provides novel complementary reactivities, but enantioselective C-H functionalization reactions with this metal remain a niche. This thesis investigates CpXIr(III) catalyzed asymmetric ...

EPFL2019

Catalytic Enantioselective α-Ketol Rearrangement

Qian Wang, Jieping Zhu, Hua Wu, Rémi Julien Sylvain Andres

A highly enantioselective a-ketol rearrangement has been developed. In the presence of a chiral Cu-bisoxazoline complex, achiral b-hydroxy-a-dicarbonyls were isomerized to chiral a-hydroxy-b-dicarbonyls and their bicyclic derivatives in excellent yields an ...

Wiley-VCH Verlag GmbH2019

Chiral Waveguides for Robust Waveguiding at the Deep Subwavelength Scale

Romain Christophe Rémy Fleury, Bakhtiyar Orazbayev, Nadège Sihame Kaïna

Routing electromagnetic energy at a scale smaller than the wavelength is a highly sought functionality in a variety of applications, including compact lightweight satellite communications, slow-waves sensors, all-optical information processing, and energy ...

American Physical Society (APS)2018

Chiral expression of adsorbed (MP) 5-amino[6] helicenes: from random structures to dense racemic crystals by surface alloying

Magalí Alejandra Lingenfelder

The chiral expression of a molecule on a surface is driven from a random solid solution on Cu(100) to a racemic crystal on a Sn/Cu(100) alloy. Density functional theory simulations reveal how the growth of the racemate is influenced by the underlying surfa ...

Royal Society of Chemistry2017

Cooperative Effects between Chiral Cp-x-Iridium(III) Catalysts and Chiral Carboxylic Acids in Enantioselective C-H Amidations of Phosphine Oxides

Nicolai Cramer, Yun-Suk Jang, Michael Christian Dieckmann

An enantioselective C-H amidation of phosphine oxides by using an iridium(III) catalyst bearing an atropchiral cyclopentadienyl (Cp-x) ligand is reported. A very strong cooperative effect between the chiral Cp-x ligand and a phthaloyl tert-leucine enabled ...

Wiley-Blackwell2017

Racemization of undesired enantiomers: Immobilization of mandelate racemase and application in a fixed bed reactor

Production of optically pure products can be based on simple unselective synthesis of racemic mixtures combined with a subsequent separation of the enantiomers; however, this approach suffers from a 50% yield limitation which can be overcome by racemizatio ...

Wiley-V C H Verlag Gmbh2016

Asymmetric Catalysis Powered by Chiral Cyclopentadienyl Ligands

Nicolai Cramer, David Kossler, Christopher Gordon Newton

Application of chiral derivatives of the versatile and ubiquitous cyclopentadienyl ligand has long remained an underdeveloped area in asymmetric catalysis. In this Perspective we highlight recent exciting results that demonstrate their enormous potential. ...

American Chemical Society2016

Stereocontrolled Self-Assembly and Self-Sorting of Luminescent Europium Tetrahedral Cages

Jean-Claude Bünzli

Coordination-directed self-assembly has become a well-established technique for the construction of functional supramolecular structures. In contrast to the most often exploited transition metals, trivalent lanthanides Ln(III) have been less utilized in th ...

American Chemical Society2015