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Concept

Tétroxyde d'osmium

Publications associées (11)

Potent and selective anticancer activity of half-sandwich ruthenium and osmium complexes with modified curcuminoid ligands

Paul Joseph Dyson, Mouna Hadiji

We have recently reported a series of half-sandwich ruthenium(ii) complexes with curcuminoid ligands showing excellent cytotoxic activities (particularly ionic derivatives containing PTA (PTA = 1,3,5-triaza-7-phosphaadamantane). In the present study, new m ...

ROYAL SOC CHEMISTRY2022

Computational characterisation of the selectivity and binding mode of mono- and binuclear transition metal based anticancer compounds

Thibaud Edouard Alistair von Erlach

The rising resistance and the severe side effects associated with classical anticancer drugs such as cisplatin or mercaptopurines has triggered the development of novel antitumourous agents based on transition metal (e.g. ruthenium, osmium, and gold) organ ...

EPFL2020

Palladium-Catalyzed Functionalization of Olefins and Alkynes: From Oxyalkynylation to Tethered Dynamic Kinetic Asymmetric Transformations (DYKAT)

Jérôme Waser, Stefano Nicolai, Bastian Antoine Rodolphe Claude Muriel, Mikus Purins, Ugo Jonathan Orcel, Luca Buzzetti, Phillip Gulliver Dominic Greenwood

This review presents an account of the palladium-catalyzed functionalizations of alkenes and alkynes developed at the Laboratory of Catalysis and Organic Synthesis (LCSO). Starting from the intramolecular oxy- and aminoalkynylation of alkenes, tethered met ...

2020

Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands

Paul Joseph Dyson, Alexey Nazarov

New ruthenium and osmium carbonyl clusters with 1,3,5-triaza-7-phosphatricyclo-[3.3.1.13.7]decane and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane ligands were synthesized using Me3NO as an initiator. The data on antiproliferative activity of ne ...

Springer Verlag2016

Anticancer Organometallic Osmium(II)-p-cymene Complexes

Paul Joseph Dyson, Rosario Scopelliti, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Osmium compounds are attracting increasing attention as potential anticancer drugs. In this context, a series of bifunctional organometallic osmium(II)-p-cymene complexes functionalized with alkyl or perfluoroalkyl groups were prepared and screened for the ...

Wiley-V C H Verlag Gmbh2015

Antiproliferative activities of trithiolato-bridged dinuclear arene osmium complexes

Paul Joseph Dyson, Benjamin Samuel Murray

Trithiolato-bridged arene osmium complexes of the general formula (p-cymene)(2)Os-2(mu-SR)(3) (R = C6H5, 1; C6H4-p-Me, 2; C6H4-p-OMe, 3; C6H4-p-Pr-i, 4; C6H4-p-But, 5; CH2C6H5, 6; CH2CH2C6H5, 7; CH2C6H4-p-Bu-t, [8](+ ...

Elsevier Science Sa2014

BODIPY-phosphane as a versatile tool for easy access to new metal-based theranostics

Angela Casini, Olivier Pierre Zava

A new BODIPY-phosphane was synthesized and proved to be a versatile tool for imaging organometallic complexes. It also led to easy access to a new family of theranostics, featuring gold, ruthenium and osmium complexes. The compounds' cytotoxicity was teste ...

Royal Soc Chemistry2013

Experimental and theoretical studies on the mechanism of hydrogenation by η6-arene β-diketiminato -ruthenium and -osmium complexes

Paul Joseph Dyson, Andrew Douglas Phillips

The β-diketiminate class of ligands is renowned for the stabilization of coordinatively unsatd. main-group and transition metal complexes. Moreover, the application and scope of transition metal β-diketiminate complexes in the catalytic transformation of o ...

2010

Synthetic Studies on the Sporolides: Exploration of the Enediyne Route

Karl Gademann, Cindy Fellay

Synthetic studies towards the construction of the cyclopenta[a]indene fragment of the heptacyclic marine metabolite sporolide are reported based on a hypothetical biosynthesis. The key step of this biogenetic proposal includes a Bergman cyclization of an e ...

Georg Thieme Verlag2010

Noniterative approach to the total asymmetric synthesis of 15-carbon polyketides and analogs with high stereodiversity

Pierre Vogel, Sandrine Gerber, Marc-Etienne Schwenter, Kai Torsten Meilert

Starting from inexpensive furan and furfuryl alcohol, a noniterative approach to the synthesis of pentadeca-1,3,5,7,9,11,13,15-octols and their derivatives has been developed. The method relies upon the double [4+3]-cycloaddition of 1,1,3-trichloro-2-oxyla ...

2005

Mono, bis, or tris(2,2'-substituted bipyridine) complexes of a metal selected from iron, ruthenium, osmium or vanadium, and preparation methods thereof

Michael Graetzel, Mohammad Khaja Nazeeruddin, Shaik Mohammed Zakeeruddin

The present invention relates to a new family of mono, bis or tris (2,2'-substituted bipyridine) complexes of a metal selected amongst iron, ruthenium, osmium or vanadium, the bipyridine being substituted by at least one electron donor group. According to ...

(Asulab S. A., Switz.).1992