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Concept

Hormone de libération des gonadotrophines hypophysaires

Publications associées (27)

Method for hormone or drug screening in a tissue sample

Cathrin Brisken, Christoph Merten, Yueyun Zhang

The present invention relates to a method for analyzing cellular responsiveness to hormones or drags in a tissue sample based on an alginate-based 3D ex vivo culture system for normal and malignant tissue microstructures and uses thereof. ...

2023

Combining ion mobility spectrometry and cryogenic ion spectroscopy with enzymatic digestion/synthesis for the study of N-linked glycans

Irina Märki

Glycans play an essential role in numerous physiological and pathological processes of living organisms. Despite their significant biological relevance, glycobiology remains one of the least explored fields of biochemistry. The intrinsic isomeric complexit ...

EPFL2023

Extended gate field-effect-transistor for sensing cortisol stress hormone

Mihai Adrian Ionescu, Hoël Maxime Guérin, Junrui Zhang, Sadegh Kamaei Bahmaei, Luca Capua, Shokoofeh Sheibani

Cortisol is a hormone released in response to stress and is a major glucocorticoid produced by adrenal glands. Here, we report a wearable sensory electronic chip using label-free detection, based on a platinum/graphene aptamer extended gate field effect tr ...

SPRINGERNATURE2021

Lactate enhancing compounds and uses thereof

Pierre Magistretti, Sylvain Eric Lengacher, Charles Léonard Finsterwald

Abstract of the invention: The present invention relates to new agents useful for stimulating release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prev ...

2020

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Chiara Cianciaruso, Steinunn Baekkeskov Hanahan, Petra Catalina Schwalie, Edward Allen Phelps

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (gamma-aminobutyric acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis. Islet GABA release has classically been described as a secretory- ...

2019

Gender medicine and oncology: report and consensus of an ESMO workshop

Jacques Fellay

Background: The importance of sex and gender as modulators of disease biology and treatment outcomes is well known in other disciplines of medicine, such as cardiology, but remains an undervalued issue in oncology. Considering the increasing evidence for t ...

OXFORD UNIV PRESS2019

Pancreatic α- and β-Cellular Clocks Have Distinct Molecular Properties and Impact on Islet Hormone Secretion and Gene Expression

Michaël Unser, Daniel Sage, Frédéric Bruno Martin Gachon, Cédric Gobet

A critical role of circadian oscillators in orchestrating insulin secretion and islet gene transcription has been demonstrated recently. However, these studies focused on whole islets and did not explore the interplay between α-cell and β-cell clocks. We p ...

2017

A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response

Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Valentina Scabia, Rachel Marcone, Laura Battista, Valérian Charles Robert Dormoy

Seventy-five percent of breast cancers are estrogen receptor α positive (ER(+)). Research on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require non-physiological hormone supplements, and patient-derived xenografts (PD ...

Elsevier2016

Murine ovarian follicle culture in PEG-hydrogel: Effects of mechanical properties and the hormones FSH and LH on development

Jeffrey Alan Hubbell

The development of an in vitro culture system, comparable to the in vivo environment in terms of effects on oocyte growth and development, could provide a valuable experimental tool for studying the mechanisms governing oocyte development as well as practi ...

Polymer Soc Korea2015

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

Kathryn Hess Bellwald, Cathrin Brisken, Rachel Marcone

Worldwide, breast cancer incidence has been increasing for decades. Exposure to reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk, and can promote disease progression. Exogenous hormones and endocrine disruptors h ...

2015

Endocrine hormones and local signals during the development of the mouse mammary gland

Cathrin Brisken, Dalya Ataca

Most of mammary gland development occurs postnatally under the control of female reproductive hormones, which in turn interact with other endocrine factors. While hormones impinge on many tissues and trigger very complex biological responses, tissue recomb ...

Wiley-Blackwell2015

Effects of clofibric acid alone and in combination with 17 beta-estradiol on mRNA abundance in primary hepatocytes isolated from rainbow trout

Kristin Schirmer

Clofibric acid (CA) is the active substance of lipid lowering drugs. It is resistant to degradation, polar in nature, and has been found ubiquitously in the aquatic environment. Though CA is classified as a peroxisomal proliferator in rodents and is consid ...

Pergamon-Elsevier Science Ltd2014

The Orphan Nuclear Receptor Nr5a2 Is Essential for Luteinization in the Female Mouse Ovary

Kristina Schoonjans

In the ovary, the follicular granulosa cells express the nuclear receptor Nr5a2 (nuclear receptor subfamily 5 group A member 2), also known as liver receptor homolog-1, and after ovulation, Nr5a2 expression persists in the corpus luteum. Previous studies d ...

Endocrine Soc2014

NR5A2 Regulates Lhb and Fshb Transcription in Gonadotrope-Like Cells In Vitro, but Is Dispensable for Gonadotropin Synthesis and Fertility In Vivo

Johan Auwerx, Kristina Schoonjans

Successful mammalian reproduction depends on proper synthesis of the pituitary-derived glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Several transcription factors cooperate to activate cell-specific and hormone-reg ...

Public Library of Science2013

Liver receptor homolog-1 is essential for pregnancy

Kristina Schoonjans

Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis(1). It is strongly expres ...

Nature Publishing Group2013

VEGFR-3 Neutralization Inhibits Ovarian Lymphangiogenesis, Follicle Maturation, and Murine Pregnancy

Jeffrey Alan Hubbell, Didier Trono, Melody Swartz

Lymphatic vessels surround follicles within the ovary, but their roles in folliculogenesis and pregnancy, as well as the necessity of Lymphangiogenesis in follicle maturation and health, are undefined. We used systemic delivery of mF4-31C1, a specific anta ...

Elsevier Science Inc2013

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Tamara Tanos

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

Monitoring proliferative activities of hormone-like odorants in human breast cancer cells by gene transcription profiling and electrical impedance spectroscopy

Horst Arthur Vogel, Cathrin Brisken, Horst Pick, Samuel Terrettaz, Olivia Baud

The human estrogen receptor alpha (ER!) mediates the proliferative action of hormones in breast cancer cells by regulating the expression of target genes to control cellular functions. Current methodologies do not permit a real-time assessment of these pro ...

Elsevier2013

The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility

Jian Wang, Friedrich Beermann, Roman Chrast

The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in v ...

2012

Regulation of transmitter release by Ca2+ and synaptotagmin: insights from a large CNS synapse

Ralf Schneggenburger, Olexiy Kochubey

Transmitter release at synapses is driven by elevated intracellular Ca2+ concentration (Ca2+) near the sites of vesicle fusion. Ca2+ signals of profoundly different amplitude and kinetics drive the phasic release component during a presynaptic ac ...

2011