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Concept

Endorphine

Publications associées (5)

Gas-phase structures reflect the pain-relief potency of enkephalin peptides

Oleg Boyarkine, Vladimir Kopysov, Aleksandr Pereverzev

We use cold ion spectroscopy and quantum-chemical computations to solve the structures of opioid peptides enkephalins in the gas phase. The derived structural parameters clearly correlate with the known pharmacological efficiency of the studied drugs, sugg ...

2019

Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex

Aurélie Lattion, Laura Lozano Montes

Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully charac ...

2018

Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets

Ursula Röthlisberger, Pablo Campomanes Ramos, Giulia Palermo, Andrea Cavalli

The fatty acid amide hydrolase (FAAH) regulates the endocannabinoid system cleaving primarily the lipid messenger anandamide. FAAH has been well characterized over the years and, importantly, it represents a promising drug target to treat several diseases, ...

2015

Altered Gaba And Somatostatin Modulation Of Proprioceptive Feedback After Spinal Cord Injury In Lamprey

While various changes occur after spinal cord lesions, their influence on functional recovery is generally unclear. We have shown changes in proprioceptor and locomotor network properties below lesion sites in the lamprey spinal cord. The proprioceptive sy ...

Pergamon-Elsevier Science Ltd2013

Phosphocreatine line with changes in localised 31P MRS of exercising muscle at 7T

Rolf Gruetter, Christine Nabuurs

The aim was to investigate changes in the line width of high-energy phosphates solely originating from the intramyocellular compartment by temporally resolved localised 31P-MRS after aerobic calf muscle exercise. Semi-Laser [2] localised 31P-MRS of gastroc ...

2011