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Concept

Lipophilie

Publications associées (10)

Multivalent Virucidal Antivirals: Synthesis, Mechanisms of Action, and Immune-stimulating Effects

Yong Zhu

Viruses initiate invasion by binding to cell surface glycoproteins. Materials mimicking the carbohydrate motifs of these glycoproteins, such as heparan sulfate (HS) and sialic acid (SA) can block viral attachment and inhibit the infection. Multivalent disp ...

EPFL2023

On the stability and necessary electrophoretic mobility of bare oil nanodroplets in water

Sylvie Roke, Halil Ibrahim Okur, Saranya Pullanchery Sankara Narayanan, Sergey Kulik

Hydrophobic oil droplets, particles, and air bubbles can be dispersed in water as kinetically stabilized dispersions. It has been established since the 19th century that such objects harbor a negative electrostatic potential roughly twice larger than the t ...

AMER INST PHYSICS2020

Specific Ion Effects at the Interface of Nanometer-Sized Droplets in Water: Structure and Stability

Sylvie Roke, Halil Ibrahim Okur, Evangelia Zdrali

The interaction of ions with interfaces influences numerous processes in chemistry, physics, and biology, while different ion species behave differently at hydrophobic or hydrophilic interfaces. Despite its importance, ion specificity and its relation to s ...

2019

Interaction of Oil and Lipids in Freestanding Lipid Bilayer Membranes Studied with Label-Free High-Throughput Wide-Field Second-Harmonic Microscopy

Sylvie Roke, Orly Bagunu Tarun, Maksim Eremchev

The interaction of oils and lipids is relevant for membrane biochemistry since the cell uses bilayer membranes, lipid droplets, and oily substances in its metabolic cycle. In addition, a variety of model lipid membrane systems, such as freestanding horizon ...

2018

Specific Ion Effects in Amphiphile Hydration and Interface Stabilization

Sylvie Roke, Yixing Chen, Rüdiger Scheu

Specific ion effects can influence many processes in aqueous solutions: protein folding, enzyme activity, self-assembly, and interface stabilization. Ionic amphiphiles are known to stabilize the oil/water interface, presumably by dipping their hydrophobic ...

Amer Chemical Soc2014

The Orientation and Charge of Water at the Hydrophobic Oil Droplet-Water Interface

Sylvie Roke

We established the charge and structure of the oil/water interface by combining zeta-potential measurements, sum frequency scattering (SFS) and molecular dynamics simulations. The SFS experiments show that the orientation of water molecules can be followed ...

2011

Sorption of hydrophobic organic compounds (HOC) in rapeseed oil bodies

Ian William Marison, Julien Boucher

Oil-bodies are minute plant organelles (0.5-2.0 mu m diameter) consisting of an oil core surrounded by a phospholipid monolayer/proteinaceous membrane. Oil-bodies have been isolated from rapeseed seeds and demonstrated to constitute a novel type of micro-c ...

Elsevier2008

Novel applications of poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers

Block copolymers are comprised of repeating chemical groups (blocks) which commonly contain at least one hydrophilic block coupled to at least one hydrophobic block, forming an amphipathic macromolecule. This molecular arrangement drives the self assembly ...

EPFL2008

Functionalized pyrrolidines as alpha-mannosidase inhibitors and growth inhibitors of human glioblastoma and melanoma cells

Pierre Vogel, Sandrine Gerber, Sylvain Favre, Hélène Fiaux

New substituted pyrrolidine-3,4-diol derivatives were prepared from D-(-)- and L-(+)-phenyl glycinol. The influence of the configuration and the substitution of the lateral side chain of these derivatives on the inhibition of 25 commercial glycosidases wer ...

2005

Two-phase partition profiling of drugs and ionisable compounds

Sorina-Mirela Ulmeanu Plass

Lipophilicity of compounds with therapeutic interest represents one of the most important physicochemical parameters in predicting and interpreting transport processes across biological barriers. This property is commonly measured as a drug | membrane part ...

EPFL2004