Concept

Agression

Publications associées (30)

Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Alexandre Claude Gustave Bacq

Early-life stress is a key risk factor for the development of neuropsychiatric disorders later in life. Neuronal cell adhesion molecules have been strongly implicated in the pathophysiology of psychiatric disorders and in modulating social behaviors associ ...

2015

Peripubertal stress-induced behavioral changes are associated with altered expression of genes involved in excitation and inhibition in the amygdala

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Orbicia Riccio Wicht

Early-life stress is a critical risk factor for developing psychopathological alterations later in life. This early adverse environment has been modeled in rats by exposure to stress during the peripubertal period-that is, corresponding to childhood and pu ...

Nature Publishing Group2014

Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti

Neuroligins (NLGNs) are cell adhesion molecules that are important for proper synaptic formation and functioning and are critical regulators of the balance between neural excitation/inhibition (E/I). Mutations in NLGNs have been linked to psychiatric disor ...

Nature Publishing Group2014

Long-term programming of enhanced aggression by peripuberty stress in female rats

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana

Human literature has linked adverse early life experiences with an increased risk to develop violent behaviors in both boys and girls. We have previously shown that male rats submitted to stress during the peripuberty period display as adults abnormal aggr ...

Elsevier2013

The interplay of conditional NCAM-knockout and chronic unpredictable stress leads to increased aggression in mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Orbicia Riccio Wicht

The neural cell adhesion molecule (NCAM) is a key regulator of brain plasticity. Substantial evidence indicates that NCAM is down-regulated by exposure to sustained stress and chronic stress seems to lead to increased aggression. In addition, constitutiona ...

Informa Healthcare2013

Female vulnerability to the development of depression-like behavior in a rat model of intimate partner violence is related to anxious temperament, coping responses, and amygdala vasopressin receptor 1a expression

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Guillaume Poirier

Exposure to violence is traumatic and an important source of mental health disturbance, yet the factors associated with victimization remain incompletely understood. The aim of the present study was to investigate factors related to vulnerability to depres ...

Frontiers Research Foundation2013

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Pierre Magistretti, Maria del Carmen Sandi Perez, Didier Trono, Maria Isabel Cordero Campana, Guillaume Poirier, Anna Claire Groner

Although adverse early life experiences have been found to increase lifetime risk to develop violent behaviors, the neurobiological mechanisms underlying these long-term effects remain unclear. We present a novel animal model for pathological aggression in ...

Nature Publishing Group2013

Increased corticosterone in peripubertal rats leads to long-lasting alterations in social exploration and aggression

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Stamatina Tzanoulinou, Vandana Veenit

Stress during childhood and adolescence enhances the risk of psychopathology later in life. We have previously shown that subjecting male rats to stress during the peripubertal period induces long-lasting effects on emotion and social behaviors. As cortico ...

Frontiers Research Foundation2013

Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Orbicia Riccio Wicht

Disturbances of the excitation/inhibition (E/I) balance in the brain were recently suggested as potential factors underlying disorders like autism and schizophrenia resulting in associated behavioral alterations including changes in social and emotional be ...

Public Library of Science2013

Role of the HPA axis in the long-term programming of social behaviors by peripuberty stress : behavioral, pharmacological and molecular approaches

Vandana Veenit

Stress during childhood and adolescence enhances the risk of psychopathology later in life. In fact, exposure to stress during this period is known to predispose individuals to the development of psychopathologies such as depression and anxiety disorders l ...

EPFL2013