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Concept

Histoire évolutive de l'œil

Publications associées (24)

A Male with Unilateral Microphthalmia Reveals a Role for TMX3 in Eye Development

Anophthalmia and microphthalmia are important birth defects, but their pathogenesis remains incompletely understood. We studied a patient with severe unilateral microphthalmia who had a 2.7 Mb deletion at chromosome 18q22.1 that was inherited from his moth ...

Public Library of Science2010

Colloidal characterization and thermodynamic stability of binary eye lens protein mixtures

Giuseppe Foffi, Nicolas Dorsaz

We present a study of binary mixtures of eye lens crystallin proteins. A coarse-grained model of aqueous aand γ-crystallin mixtures based on molecular dynamics simulations and SANS experiments is proposed. Thermodynamic perturbation theory is implemented t ...

2009

Spinodal surface of a free energy model for eye lens protein mixtures: Relevance for cataracts

Giuseppe Foffi, Nicolas Dorsaz

We studied the phase behavior of a model binary mixture of eye lens crystallin proteins using first-order thermodynamic perturbation theory. The instability boundary, or spinodal surface, was found to be very sensitive to the strength of the attraction bet ...

Amer Inst Physics, 2 Huntington Quadrangle, Ste 1No1 D, Melville, Ny 11747-4501 Usa2009

A colloidal approach to eye lens protein mixtures : relevance for cataract formation

Nicolas Dorsaz

A broad and constantly growing class of diseases, such as Alzheimer's disease, sickle-cell or cataract, involves protein association phenomena as an essential aspect. The common denominator of all the members of this class of molecular condensation disease ...

EPFL2009