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Concept

Effector (biology)

Publications associées (24)

Role of microRNAs in tumor-associated macrophages

Caroline Maïté Monnard

Tumor-associated macrophages (TAMs) infiltrate both mouse and human tumors, typically in high numbers, and display complex interactions with cancer cells, endothelial cells (ECs) and other immune cells. TAMs comprise molecularly distinct subsets. Two such ...

EPFL2016

Multivalency governs HP1α association dynamics with the silent chromatin state

Beat Fierz, Louise Catherine Bryan, Sinan Kilic, Andreas Linus Bachmann

Multivalent interactions between effector proteins and histone post-translational modifications are an elementary mechanism of dynamic chromatin signalling. Here we elucidate the mechanism how heterochromatin protein 1α (HP1α), a multivalent effector, is e ...

Nature Research2015

Structure and properties of the C-terminal beta-helical domain of VgrG protein from Escherichia coli O157

Petr Leiman

The bacterial Type 6 secretion system (T6SS) translocates protein toxins (also called effectors) from the cytosol of a T6SS-carrying cell to a target cell by a syringe-like supramolecular complex resembling a contractile tail of bacteriophages. Valine-glyc ...

Oxford University Press2014

An acetylation rheostat for the control of muscle energy homeostasis

Johan Auwerx, Keir Joe Menzies

In recent years, the role of acetylation has gained ground as an essential modulator of intermediary metabolism in skeletal muscle. Imbalance in energy homeostasis or chronic cellular stress, due to diet, aging, or disease, translate into alterations in th ...

Society for Endocrinology2013