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Concept

Alternatives to Darwinian evolution

Publications associées (26)

Variational quantum time evolution without the quantum geometric tensor

Giuseppe Carleo, Jannes Willy E. Nys, Riccardo Rossi, Julien Sebastian Gacon

Realand imaginary -time quantum state evolutions are crucial in physics and chemistry for exploring quantum dynamics, preparing ground states, and computing thermodynamic observables. On near -term devices, variational quantum time evolution is a promising ...

Amer Physical Soc2024

Information Theory in Transmembrane Transport

Solange Marie Flatt

The past decades have seen the advent of information theory in various fields, from quantum physics to cosmology. At an intermediary scale between atomic and cosmological scales are biological systems and in particular the cell, as a constitutive element o ...

EPFL2023

Analyse des logiques de choix modal auprès de la population active dans l'aire urbaine de Bienne

Vincent Kaufmann, Guillaume Simon Joseph Drevon, Marc Antoine Messer, Ludy Juliana González Villamizar, Eloi Antoine Maël Bernier

Encourager le report modal des transports individuels vers des moyens de transports moins polluants constitue aujourd’hui l’objectif affiché des politiques de transport à travers toute l’Europe (Banister 2005, Flamm 2004). Cet objectif ambitieux exige une ...

EPFL2020

Analyse des logiques de choix modal auprès de la population active urbaine : étude comparée du Grand Genève, du Canton de Vaud, et des agglomérations de Berne et de Bienne

Vincent Kaufmann, Guillaume Simon Joseph Drevon, Marc Antoine Messer, Ludy Juliana González Villamizar, Eloi Antoine Maël Bernier

EPFL2020

Generation of chiral asymmetry via helical magnetic fields

Salim Bennouna

It is well known that helical magnetic fields undergo a so-called inverse cascade by which their correlation length grows due to the conservation of magnetic helicity in classical ideal magnetohydro-dynamics (MHD). At high energies above approximately 10 M ...

American Physical Society2020

Protein Structural Information and Evolutionary Landscape by In Vitro Evolution

Paolo De Los Rios

Protein structure is tightly intertwined with function according to the laws of evolution. Understanding how structure determines function has been the aim of structural biology for decades. Here, we have wondered instead whether it is possible to exploit ...

OXFORD UNIV PRESS2020

Limits on amplifiers of natural selection under death-Birth updating

Andreas Pavlogiannis

The fixation probability of a single mutant invading a population of residents is among the most widely-studied quantities in evolutionary dynamics. Amplifiers of natural selection are population structures that increase the fixation probability of advanta ...

2020

MPA-SSA, design and test of a 65 nm ASIC-based system for particle tracking at HL-LHC featuring on-chip particle discrimination

Yusuf Leblebici, Simone Scarfì, Alessandro Caratelli

Particle tracking detectors for High Energy Physics need a new readout technique to cope with the increase of the collision rate foreseen for the High Luminosity LHC upgrade. In particular, the selection of interesting physics events at the first trigger s ...

IEEE2019

Increasing reuse in learning objects authoring: a case study with the Cacuria tool

Roberto Gerson De Albuquerque Azevedo

Artifacts and best practices reuse as a way of improving educational resources and easing and speeding up the authoring process have been an important theme since the earliest research efforts on Learning Objects (LOs). In such a context, authoring tools t ...

ASSOC COMPUTING MACHINERY2019

Population structure determines the tradeoff between fixation probability and fixation time

Andreas Pavlogiannis

The rate of biological evolution depends on the fixation probability and on the fixation time of new mutants. Intensive research has focused on identifying population structures that augment the fixation probability of advantageous mutants. But these ampli ...

Springer2019

Linking a mutation to survival in wild mice

Jeffrey David Jensen, Stefan Jean Laurent, Susanne Petra Pfeifer, Matthieu Foll

Adaptive evolution in new or changing environments can be difficult to predict because the functional connections between genotype, phenotype, and fitness are complex. Here, we make these explicit connections by combining field and laboratory experiments i ...

American Association for the Advancement of Science2019

The evolution of multiple active site configurations in a designed enzyme

Ganna Gryn'ova

Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can ...

Nature Publishing Group2018

Soil protistology rebooted: 30 fundamental questions to start with

Vincent Eric Jules Jassey, Enrique Lara

Protists are the most diverse eukaryotes. These microbes are keystone organisms of soil ecosystems and regulate essential processes of soil fertility such as nutrient cycling and plant growth. Despite this, protists have received little scientific attentio ...

Pergamon-Elsevier Science Ltd2017

Hierarchical Fingertip Space: A Unified Framework for Grasp Planning and In-Hand Grasp Adaptation

Aude Billard, Miao Li

We present a unified framework for grasp planning and in-hand grasp adaptation using visual, tactile, and proprioceptive feedback. The main objective of the proposed framework is to enable fingertip grasping by addressing problems of changed weight of the ...

Institute of Electrical and Electronics Engineers2016

Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

Luciano Andres Abriata

The understanding of protein evolution depends on the ability to relate the impact of mutations on molecular traits to organismal fitness. Biological activity and robustness have been regarded as important features in shaping protein evolutionary landscape ...

Oxford Univ Press2016

Direct evidence for charge stripes in a layered cobalt oxide

Peter Babkevich, Paul Gregory Freeman

Recent experiments indicate that static stripe-like charge order is generic to the hole-doped copper oxide superconductors and competes with superconductivity. Here we show that a similar type of charge order is present in La-5/Sr-3(1)/3CoO4, an insulating ...

Springer2016

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

Jeffrey David Jensen, Matthieu Foll, Claudia Bank, Sebastian Matuszewski, Hyunjin Shim

The rapid evolution of drug resistance remains a critical public health concern. The treatment of influenza A virus (IAV) has proven particularly challenging, due to the ability of the virus to develop resistance against current antivirals and vaccines. He ...

Wiley-Blackwell2016

Catch Me if You Can: Adaptation from Standing Genetic Variation to a Moving Phenotypic Optimum

Sebastian Matuszewski

Adaptation lies at the heart of Darwinian evolution. Accordingly, numerous studies have tried to provide a formal framework for the description of the adaptive process. Of these, two complementary modeling approaches have emerged: While so-called adaptive- ...

2015

Assessment of phase-field-crystal concepts using long-time molecular dynamics

William Curtin

The ability of the phase-field-crystal (PFC) model to quantitatively predict atomistic defect structures in crystalline solids is addressed. First, general aspects of the PFC model are discussed within the context of obtaining quantitative results in solid ...

American Physical Society2015

Unraveling Patterns of Site-to-Site Synonymous Rates Variation and Associated Gene Properties of Protein Domains and Families

Slavica Dimitrieva Janeva

In protein-coding genes, synonymous mutations are often thought not to affect fitness and therefore are not subject to natural selection. Yet increasingly, cases of non-neutral evolution at certain synonymous sites were reported over the last decade. To ev ...

Public Library of Science2014