With the increasing trend of mobility of the human population, vehicles have to face the problem of primary energy resources scarcity. The vehicles need higher efficiency and better adaptation to the alternative energy sources. The need to improve the effi ...
Understanding patterns of spontaneous mutations is of fundamental interest in studies of human genome evolution and genetic disease. Here, we used extremely rare variants in humans to model the molecular spectrum of single-nucleotide mutations. Compared to ...
Cold Spring Harbor Lab Press, Publications Dept2013
The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastabl ...
What is the relationship between the complexity and the fitness of evolved organisms, whether natural or artificial? It has been asserted, primarily based on empirical data, that the complexity of plants and animals increases as their fitness within a part ...
It remains a central problem in population genetics to infer the past action of natural selection, and these inferences pose a challenge because demographic events will also substantially affect patterns of polymorphism and divergence. Thus it is imperativ ...
Cross-diffusion driven instabilities have gained a considerable attention in the field of population dynamics, mainly due to their ability to predict some important features in the study of spatial distribution of species in ecological systems. This paper ...
Evolutionary algorithms were proposed to automatically find solutions to computational problems, much like evolution discovers new adaptive traits. Lately, they have been used to address challenging questions about the evolution of modularity, the genetic ...