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Concept

Rhinite

Publications associées (11)

Fungal Contaminants in Energy Efficient Dwellings: Impact of Ventilation Type and Level of Urbanization

Dusan Licina, Shen Yang

The presence of growing fungi in the indoor environment has been associated with the development of respiratory problems such as asthma or allergic rhinitis, as well as the worsening of respiratory pathologies. Their proliferation indoors could be a result ...

2020

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Nicola Harris, Tiffany Babette Angélique Bouchery, Julia Esser-von Bieren

Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...

WILEY2019

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Kai Johnsson, Jairo Alexander Lozano Moreno, Yann Mathieu Pierson

Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, the generation of nitric oxide, and pain(1,2). ...

NATURE PUBLISHING GROUP2018

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Nicola Harris, Laure Menin, Alessandra Piersigilli, Alexis Rapin, Jacques Rougemont, Mario Michael Zaiss, Lalit Kumar Dubey, Ilaria Mosconi, Luc Xavier Marie Lebon

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or w ...

Elsevier2015

Microbiological characterization of 3193 French dwellings of Elfe cohort children

François Gillet

Although exposure to indoor microorganisms in early life has already been associated with respiratory illness or allergy protection, only a few studies have performed standardized samplings and specific microbial analysis. Moreover, most do not target the ...

Elsevier2015

Thymic stromal lymphopoietin plays divergent roles in murine models of atopic and nonatopic airway inflammation

Nicola Harris, Ilaria Mosconi

BackgroundThymic stromal lymphopoietin (TSLP) is a cytokine primarily produced by epithelial cells, which has been shown to be a potent inducer of T-helper 2 (Th2)-type responses. However, TSLP has pleiotropic effects upon immune cells, and although extens ...

Wiley-Blackwell2014

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

Nicola Harris

Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such host-microbe crosstalk influences inflammation in peripheral tissues, such as the ...

Nature Publishing Group2014

Antibodies and IL-3 support helminth-induced basophil expansion

Nicola Harris, Mario Michael Zaiss, Julia Esser-von Bieren, Tina Herbst, Manuel Kulagin

Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely unknow ...

National Academy of Sciences2012

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

Nicola Harris, Tina Herbst

RATIONALE: The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora. OBJECTIVES: To ascertain the relevance of commensal bacteria upo ...

2011

Major mite allergen Der f 1 concentration is reduced in buildings with improved energy performance

Claude-Alain Roulet

Background: Environmental conditions play a crucial role in mite growth, and optimal environmental control is key in the prevention of airway inflammation in chronic allergic rhinoconjunctivitis or asthma. ...

2010

Solder Doped Polycaprolactone Scaffold Enables Solder Doped Polycaprolactone Scaffold Enables. Reproducible Laser Tissue Soldering

Heinrich Hofmann, Alke Fink, Vianney Bernau

During the last 40 years a focus in research was put on sutureless tissue fusion, to handle the limits of conventional suturing such as vascular wall damage due to the enetrating needle, intraluminal foreign body reactions caused by non-absorbable suture m ...

2008