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Publications associées (29)

Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

Bruno Lemaitre, Jan Paul Dudzic, Elodie Julie Virginie Ramond

Drosophila melanogaster's blood cells (hemocytes) play essential roles in wound healing and are involved in clearing microbial infections. Here, we report the transcriptional changes of larval plasmatocytes after clean injury or infection with the Gram-neg ...

PUBLIC LIBRARY SCIENCE2020

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

Philipp Bucher, Cathrin Brisken, Giovanna Ambrosini, Rachel Marcone, Céline Berthe Constantin, Dalya Ataca, Marie Shamseddin, Csaba Ferenc László, Marian Caikovski, Patrik Aouad

Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenes ...

Nature Research2020

Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment

Matthias Lütolf, Olaia Maria Naveiras Torres-Quiroga, Aline Roch, Philipp Sebastian Lienemann, Stéphanie Elisabeth Metzger, Queralt Vallmajó Martín

The treatment of bone defects with recombinant bone morphogenetic protein-2 (BMP-2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low-dose BMP-2-based bone regeneration by mob ...

WILEY2020

Statistical Fatigue Investigation and Failure Prediction of a Healable Composite System

Véronique Michaud, Amaël Maximilien Cohades, Nathan Klaus Hostettler

Fiber reinforced polymers are massively used as an alternative to metals in structural applications. The brittle nature of their matrix, however, makes them more susceptible to crack formation and propagation resulting in costly repair operations and incre ...

2020

Soft Self-Healing Nanocomposites

Véronique Michaud, Yves Leterrier

This review article provides an overview of the research and applications of soft self-healing polymers and their nanocomposites. A number of concepts based on physical and chemical interactions have been explored to create dynamic and reversible gel and e ...

FRONTIERS MEDIA SA2019

Surface and bulk stresses drive morphological changes in fibrous microtissues

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas

Engineered fibrous tissues consisting of cells encapsulated within collagen gels are widely used three-dimensional (3D) in vitro models of morphogenesis and wound healing. While cell-mediated matrix remodeling that occurs within these scaffolds has been ex ...

2019

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Jeffrey Alan Hubbell, Matthias Lütolf, Yoji Tabata

During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiog ...

AMER SOC HEMATOLOGY2019

Adamts18 Function in Mammary Gland Development

Dalya Ataca

Ovarian hormones control mammary gland development and impinge on breast carcinogenesis acting via their cognate receptors in the luminal epithelium. The extracellular matrix has a key role in physiology and disease but how the two are linked is poorly und ...

EPFL2019

Inkjet Printed Carbon Nanotube Electrodes for Measuring Pyocyaninand Uric Acid in a Wound Fluid Simulant and Culture Media

Hubert Girault, Andreas Stephan Lesch, Milica Jovic

Polyacrylamide-coated, carbon nanotube (PA/CNT)electrodes were prepared by an ink-jet printing process and used to measure pyocyanin and uric acid in a wound fluid simulant at 37 oC.These two moleculesare potential indicators of infection and therefore the ...

2019