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Concept

Fer (médicament)

Publications associées (29)

Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation

Antonia Neels, Marianne Liebi, Tiberiu Totu

Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions such as chronic kidney disease, heart failure and various inflammatory conditions. Even though a ple ...

Elsevier2024

Phase Transformation-Induced Interfacial Debonding of Silica Inclusions in Iron

Andreas Mortensen, Alejandra Inés Slagter, David Hernandez Escobar, Julie Nathalie S Gheysen

We document that in unstressed, undeformed, samples of pure iron containing silica inclusions precipitated by melt deoxidation, the iron matrix and a small fraction of the silica inclusions are locally separated at room temperature by a void. Thermal cycli ...

Springer2023

Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

Xavier Fernandez-Real Girona

Background: The gut microbiome and iron status are known to play a role in the pathophysiology of nonalcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear. Results: Here, we applied an integrative systems medicine approa ...

2021

Factors influencing safety and efficacy of intravenous iron-carbohydrate nanomedicines: From production to clinical practice

Heinrich Hofmann

Iron deficiency is an important subclinical disease affecting over one billion people worldwide. A growing body of clinical records supports the use of intravenous iron-carbohydrate complexes for patients where iron replenishment is necessary and oral iron ...

2020

Spin cascade and doming in ferric hemes: Femtosecond X-ray absorption and X-ray emission studies

Majed Chergui, Wojciech Gawelda, Giulia Fulvia Mancini, Christopher Alexander Arrell, Frederico Alves Lima, Oliviero Cannelli, Dominik Kinschel, Camila Bacellar Cases Da Silveira, Jérémy Raymond Jean Maurice Rouxel, Rebecca Ann Ingle

The structure-function relationship is at the heart of biology, and major protein deformations are correlated to specific functions. For ferrous heme proteins, doming is associated with the respiratory function in hemoglobin and myoglobins. Cytochrome c (C ...

National Academy of Sciences2020

Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster

Bruno Lemaitre, Jean Philippe Boquete, Alice Marra, Igor Iatsenko

Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by iron-binding proteins called transferrins. Despite many studies on antimicrobial activity of transferrins in vitro, their specific in vivo functions are poorl ...

National Academy of Sciences2020

Iron-Catalyzed Reductive Coupling of Alkyl Iodides with Alkynes To Yield cis-Olefins: Mechanistic Insights from Computation

Xile Hu

In a recent study, a new procedure for Z-selective olefin synthesis by reductive coupling of alkyl iodides with terminal alkynes in the presence of iron salts is described. This transformation is representative of many newly developed synthetic routes thro ...

AMER CHEMICAL SOC2020

Linking Isotope Exchange with Fe(II)-Catalyzed Dissolution of Iron(hydr)oxides in the Presence of the Bacterial Siderophore Desferrioxamine-B

Janet Gordon Hering

Dissolution of Fe(III) phases is a key process in making iron available to biota and in the mobilization of associated trace elements. Recently, we have demonstrated that submicromolar concentrations of Fe(II) significantly accelerate rates of ligand-contr ...

AMER CHEMICAL SOC2020

Enhancing solar disinfection of water in PET bottles by optimized in-situ formation of iron oxide films. From heterogeneous to homogeneous action modes with H2O2 vs. O-2 - Part 2: Direct use of (natural) iron oxides

César Pulgarin, Sami Rtimi, Stefanos Giannakis

Solar disinfection (SODIS) is a well-accepted intervention method, leading to an improvement in contaminated water sources. In this work, we attempted to further enhance the bacterial inactivation process during light exposure. By means of iron oxide addit ...

ELSEVIER SCIENCE SA2019

Soluble and Solid Iron Reduction Assays with Desulfitobacterium hafniense

Julien Maillard

There is a pressing need to develop sustainable and efficient methods to protect and stabilize iron objects. To develop a conservation-restoration method for corroded iron objects, this bio-protocol presents the steps to investigate reductive dissolution o ...

2018

Iron phosphate nanoparticles for food fortification: Biological effects in rats and human cell lines

Christian Ludwig

Nanotechnology offers new opportunities for providing health benefits in foods. Food fortification with iron phosphate nanoparticles (FePO4 NPs) is a promising new approach to reducing iron deficiency because FePO4 NPs combine high bioavailability with sup ...

Informa Healthcare2017

Stereoselective synthesis of alkenes via base-metal-catalyzed addition reactions to alkynes and activation of hydrogen peroxide and carbon dioxide by iron complexes

Fedor Zhurkin

Alkene functionality can be found in the majority of natural products, drugs, catalysts and organic materials. Therefore, methods of C-C double bond formation constitute a cornerstone of organic synthesis. Selective formation of either (Z)- or (E)-isomer i ...

EPFL2017

Photoaquation Mechanism of Hexacyanoferrate(II) Ions: Ultrafast 2D UV and Transient Visible and IR Spectroscopies

Majed Chergui, Thomas James Penfold, Gerald Auböck, Marco Eli Reinhard

Ferrous iron(II) hexacyanide in aqueous solutions is known to undergo photoionization and photoaquation reactions depending on the excitation wavelength. To investigate this wavelength dependence, we implemented ultrafast two-dimensional UV transient absor ...

American Chemical Society2017

Castles fall from inside: Evidence for dominant internal photo-catalytic mechanisms during treatment of Saccharomyces cerevisiae by photo-Fenton at near-neutral pH

César Pulgarin, Sami Rtimi, Stefanos Giannakis, Cristina del Socorro Lonfat

In this work, the antimicrobial effects of the photo-Fenton process on yeast cells were tested (Saccharomyces cerevisiae), an essential eukaryotic unicellular model of living cells. Near-neutral pH was used in all studies, while iron sulfate and iron citra ...

Elsevier2016

Overhauser-enhanced magnetic resonance elastography

Arnaud Comment, Najat Salameh

Magnetic resonance elastography (MRE) is a powerful technique to assess the mechanical properties of living tissue. However, it suffers from reduced sensitivity in regions with short T-2 and T-2* such as in tissue with high concentrations of paramagnetic i ...

Wiley-Blackwell2016

Enhancement of the Fenton and photo-Fenton processes by components found in wastewater from the industrial processing of natural products: The possibilities of cork boiling wastewater reuse

César Pulgarin, Stefanos Papoutsakis

Some wastewaters from the industrial processing of natural products, such as cork boiling wastewater (CBW), have been known to contain high quantities of polyphenolic compounds that are capable of forming complexes with ferric and ferrous iron and even con ...

Elsevier2016

Catalytic Applications and Mechanistic Investigations of Iron Bis(oxazolinylphenyl)amino Pincer Complexes in Kumada Cross Coupling and Hydrosilylation Reactions

Gerald Bauer

The aim of the project was to investigate iron bis(oxazolinylphenyl)amino (bopa) pincer complexes as pre-catalysts in the enantioselective Kumada cross-coupling of non-activated alkyl halides with aryl Grignard reagents. From this preliminary cross-couplin ...

EPFL2015

Iron regulatory proteins and their role in controlling iron metabolism

Cellular iron homeostasis is regulated by post-transcriptional feedback mechanisms, which control the expression of proteins involved in iron uptake, release and storage. Two cytoplasmic proteins with mRNA-binding properties, iron regulatory proteins 1 and ...

Royal Soc Chemistry2015

Hydrogen Storage in the Carbon Dioxide - Formic Acid Cycle

Gabor Laurenczy, Cornel Fink, Mickael Montandon-Clerc

This year Mankind will release about 39 Gt carbon dioxide into the earth's atmosphere, where it acts as a greenhouse gas. The chemical transformation of carbon dioxide into useful products becomes increasingly important, as the CO2 concentration in the atm ...

Swiss Chemical Soc2015

Iron Pincer Complexes as Catalysts and Intermediates in Alkyl Aryl Kumada Coupling Reactions

Rosario Scopelliti, Xile Hu, Matthew Wodrich, Gerald Bauer

Iron-catalyzed alkylaryl Kumada coupling has developed into an efficient synthetic method, yet its mechanism remains vague. Here, we apply a bis(oxazolinylphenyl)amido pincer ligand (Bopa) to stabilize the catalytically active Fe center, resulting in isola ...

American Chemical Society2015