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Concept

Herpes simplex virus

Publications associées (27)

Virus-Mediated Cell-Cell Fusion

Lucie Josepha Marie Bracq

Cell-cell fusion between eukaryotic cells is a general process involved in many physiological and pathological conditions, including infections by bacteria, parasites, and viruses. As obligate intracellular pathogens, viruses use intracellular machineries ...

2020

Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation

Suliana Manley, Christian Sieben

Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment factor (AF). Since sialic acid alone cannot fulfill ...

2020

Inhibition of influenza virus activity by the bovine seminal plasma protein PDC-109

Christian Sieben

A number of viruses causing sexually transmissible diseases are transmitted via mammalian seminal plasma. Several components of seminal plasma have been shown to influence those viruses and their physiological impact. To unravel whether components of semin ...

SPRINGER2019

Dynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies

David Lyndon Emsley, Marc Anthony Caporini

We report dynamic nuclear polarization (DNP)-enhanced magic-angle spinning (MAS) NMR spectroscopy in viral capsids from HIV-1 and bacteriophage AP205. Viruses regulate their life cycles and infectivity through modulation of their structures and dynamics. W ...

2019

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Francesco Stellacci, Paulo Henrique Jacob Silva, Ahmet Bekdemir, Valeria Cagno, Emma-Rose Janecek, Samuel Thomas Jones

Viral infections kill millions yearly. Available antiviral drugs are virus-specific and active against a limited panel of human pathogens. There are broad-spectrum substances that prevent the first step of virus–cell interaction by mimicking heparan sulfat ...

2018

Genotypic, phenotypic and mechanistic insights into viruses with resistance to common water disinfectants

Qingxia Zhong

Infectious diseases caused by waterborne viruses contribute to the global disease burden. An effective barrier to prevent the discharge of waterborne viruses is a disinfection step, yet disinfection is not always efficient at inactivating viruses. This the ...

EPFL2017

Viruses at solid-water interfaces: A systematic assessment of interactions driving adsorption

Tamar Kohn, Anne Thérèse Sigstam, Meret Aeppli, Antonius Magdi Hakeem Armanious

Adsorption to solid-water interfaces is a major process governing the fate of waterborne viruses in natural and engineered systems. The relative contributions of different interaction forces to adsorption and their dependence on the physicochemical propert ...

Amer Chemical Soc2016