Concept

Membrane androgen receptor

Membrane androgen receptors (mARs) are a group of G protein-coupled receptors (GPCRs) which bind and are activated by testosterone and/or other androgens. Unlike the androgen receptor (AR), a nuclear receptor which mediates its effects via genomic mechanisms, mARs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades. Known or proposed mARs include ZIP9 and GPRC6A. GPRC6A has been found to be involved in testicular function and prostate cancer. mARs have also been found to be expressed in breast cancer cells. Activation of mARs by testosterone has been found to increase skeletal muscle strength, indicating potential anabolic effects. mARs have also been implicated in the antigonadotropic effects of androgens. 3α-Androstanediol, an active metabolite of dihydrotestosterone (DHT) and a weak androgen as well as a neurosteroid via acting as a positive allosteric modulator of the GABAA receptor, rapidly influences sexual receptivity and behavior in animals, an effect that is GABAA receptor-dependent.

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https://en.wikipedia.org/wiki/Membrane_androgen_receptor

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Publications associées (7)

Abstract B076: TRIM24 degradation counteracts adaptation to androgen receptor inhibition in prostate cancer

The androgen receptor (AR) is the primary therapeutic target in prostate cancer. While androgen deprivation therapy (ADT) and androgen receptor signaling inhibitors (ARSi) are effective, the disease eventually progresses to fatal castration-resistant prostate cancer (CRPC). That said, little is known about the mechanisms in residual disease that initiates tumor relapse upon ADT/ARSi. Here, we discover a crucial role for TRIM24 in supporting the survival of residual cell clusters primed for tumor relapse in

American Association for Cancer Research (AACR)2026

A modular patient-derived organoid–xenograft platform reveals molecular and clinical trajectories of prostate cancer progression

Patient-derived organoids (PDOs) are becoming increasingly important in prostate cancer (PCa) translational research. However, direct proof-of-concept studies demonstrating their ability to model disease evolution, identify relevant biomarkers, and accurately predict treatment response in PCa patients, remain scarce. Here, we report the establishment of serially transplantable xenografts series derived from two advanced PCa PDO lines, which can be further re-cultured as organoids. Newly-generated model seri

bioRxiv2026

Reprogramming GPCR Specificity: Engineering CXCR2 for Selective CXCL5 Binding and Cellular Signaling

Metastasis significantly increases the lethality of cancer, as it is responsible for 90% of cancer-associated deaths. Recently, soluble molecules have been identified as biomarkers for early metastasis, where a crosstalk between granulocytes, platelets, and cancerous cells happens and the metastatic niche is formed to favor the extravasation of tumor cells. The CXCR2 receptor present in granulocytes is responsible for its migration towards this site. Thanks to protein engineering we can take advantage of th

EPFL2026

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Personnes associées (3)

Kathryn Hess Bellwald

Kathryn Hess Bellwald received her PhD from MIT in 1989 and held positions at the universities of Stockholm, Nice, and Toronto before moving to the EPFL.Her research focuses on algebraic topology and its applications, primarily in the life sciences, but also in materials science. She has published extensively on topics in pure algebraic topology including homotopy theory, operad theory, and algebraic K-theory. On the applied side, she has elaborated methods based on topological data analysis for high-throughput screening of nanoporous crystalline materials, classification and synthesis of neuron morphologies, and classification of neuronal network dynamics. She has also developed and applied innovative topological approaches to network theory, leading to a powerful, parameter-free mathematical framework relating the activity of a neural network to its underlying structure, both locally and globally.In 2016 she was elected to Swiss Academy of Engineering Sciences and was named a fellow of the American Mathematical Society and a distinguished speaker of the European Mathematical Society in 2017. In 2021 she gave an invited Public Lecture at the European Congress of Mathematicians. She has won several teaching prizes at EPFL, including the Crédit Suisse teaching prize and the Polysphère d’Or.

Laura Battista

Giovanna Ambrosini

Current Position Senior Scientist, School of Life Sciences, Bioinformatics Competence Center, école Polythechnique Fédérale de Lausanne, Lausanne.Senior bioinformatician and software engineer with proven experience working in higher education institutions. Solid experience in scientific computing and web design. Proficient in physics and computational genomics, with a focus on high-throughput genomic sequencing data analysis (ChIP-seq, ATAC-seq, RNA-seq, scRNA-seq, and exome sequencing) and other types of

Concepts associés (2)

Testostérone (médicament)

La testostérone est un médicament et une hormone stéroïde naturelle. Elle est utilisée pour traiter l' hypogonadisme masculin, la dysphorie de genre et certains types de cancer du sein. Elle peut également être utilisé pour augmenter la capacité athlétique sous forme de dopage .On ne sait pas exactement si l'utilisation de la testostérone pour remédier aux faibles niveaux dus au vieillissement est bénéfique ou nocive. La testostérone peut être utilisée sous forme de gel ou de patch à appliquer sur la peau, à injecter dans un muscle, à placer dans la joue ou à prendre par la bouche.

Stéroïde neuroactif

vignette|Différents analogues du groupe R pour les neurostéroïdes. Un stéroïde neuroactif (ou neurostéroide) est un type de stéroïde qui altère rapidement l'excitabilité neuronale par une interaction avec les récepteurs ionotropes. De plus, ces stéroïdes peuvent exercer un effet sur l'expression génétique par les récepteurs des stéroïdes intracellulaire. Les neurosteroïdes ont une large palette d'applications cliniques, allant dans la sédation au traitement de l'épilepsie et des traumatismes crâniens.

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