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Toxicité de l'oxygène

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Publications associées (31)

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Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Wee Han Ang

The cytotoxicity of cisplatin (cDDP) is enhanced when co-administered with ethacrynic acid (EA), a glutathione S-transferase (GST) inhibito r. A Pt-lV EA conjugate containing a cDDP core and two axial ethacrynate ligands (compound 1) was shown to be an ex ...

2018

Multispectral Near-Infrared Optical Tomography for Cancer Hypoxia Study in Mice

Matthias Wolf, Scott Anthony Lindner

Oxygenation of a tumor is one of the most important predictive factors: hypoxia is associated with aggressive tumors and substantially lower survival rate. Despite this high relevance of tumor oxygenation, there is currently no bedside technique available ...

SPRINGER INTERNATIONAL PUBLISHING AG2018

Defect chemistry of methylammonium lead iodide

Alessandro Senocrate

The present work deals with the defect chemistry and charge transport properties in halide perovskites, and in particular in the archetypal methylammonium lead iodide. These materials are extensively researched due to their very promising application as li ...

EPFL2018

In vivo measurement of the tissue oxygenation by time-resolved luminescence spectroscopy of protoporphyrin IX: Strategies to minimize artefacts associated with photoproducts

Georges Wagnières, Veronika Huntosova, Emmanuel Louis Arthur Gerelli

The determination of the oxygen partial pressure (pO(2)) in real time in living biological tissues is of high interest for numerous therapeutics, including photodynamic therapy (PDT) and radiotherapy. The minimally invasive and real-time measurement of the ...

Spie-Int Soc Optical Engineering2017

Negligible interaction of [Ru(Phen) 3 ] 2+ with human serum albumin makes it promising for a reliable in vivo assessment of the tissue oxygenation

Georges Wagnières, Veronika Huntosova

The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3]2+, phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3]2+ luminescence properties. Nowad ...

Elsevier2017

Oxygen depletion in Lake Geneva

Robert Vincent Schwefel

Low oxygen concentrations remain a global concern for the ecological health of lakes. High nutrient inputs and climate-induced changes in stratification and mixing are anthropogenic threats which largely impact aquatic oxygen budgets and overall ecosystem ...

EPFL2017

New insights into ROS dynamics: a multi-layered microfluidic chip for ecotoxicological studies on aquatic microorganisms

Olivier Martin, Christian Santschi, Volodymyr Koman, Nadia Rachel Von Moos

Reactive oxygen species (ROS) play an important role in the life of every cell, including cellular defense and signaling mechanisms. Continuous and quantitative ROS sensing can provide valuable information about the cell state, but it remains a challenge t ...

Informa Healthcare2016

Measurement of pO2 by luminescence lifetime spectroscopy: A comparative study of the phototoxicity and sensitivity of [Ru(Phen)3]2+ and PdTCPP in vivo

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Veronika Huntosova

Dysfunctions in tissue metabolism can be detected at early stages by oxygen partial pressure (pO(2)) measurement. The measurement of emission lifetimes offers very promising and non-invasive approach to estimate pO(2) in vivo. This study compares two exten ...

Wiley-V C H Verlag Gmbh2016

Effect of PpIX photoproducts formation on pO2 measurement by time-resolved delayed fluorescence spectroscopy of PpIX in solution and in vivo

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Emmanuel Louis Arthur Gerelli, Veronika Huntosova

The measurement of Protoporphyrin IX delayed fluorescence lifetime is a minimally invasive method for monitoring the levels of oxygen in cells and tissues. The excitation of Protoporphyrin IX during this measurement can lead to the formation of photoproduc ...

Elsevier Science Sa2016

Oxygen defects in amorphous Al2O3: A hybrid functional study

Alfredo Pasquarello, Francesco Ambrosio, Zhendong Guo

The electronic properties of the oxygen vacancy and interstitial in amorphous Al2O3 are studied via ab initio molecular dynamics simulations and hybrid functional calculations. Our results indicate that these defects do not occur in amorphous Al2O3, due to ...

American Institute of Physics2016

Molecular Origin and Electrochemical Influence of Capacitive Surface States on Iron Oxide Photoanodes

Michael Graetzel, Yelin Hu, Florent Alexandre Boudoire

The origin, the nature, and the electronic structure of surface defects causing surface states on metal oxides and their role in solar water splitting have been under scrutiny for several decades. In the present study, the surface of hematite films is trea ...

American Chemical Society2016