Publications associées à Guerre biologique

Biological material pooling device for biological or biomolecule purification

Bart Deplancke, Riccardo Dainese, Daniel Alpern

The present invention concerns a biological material pooling device for biological or biomolecule purification comprising a receptacle including a first orifice comprising ordefining a rectangular opening, the receptacle being configured to receive at leas ...

2023

A benchmark dataset for machine learning in ecotoxicology

Kristin Schirmer, Marco Baity-Jesi, Fernando Perez Cruz

The use of machine learning for predicting ecotoxicological outcomes is promising, but underutilized. The curation of data with informative features requires both expertise in machine learning as well as a strong biological and ecotoxicological background, ...

Nature Portfolio2023

Industrial Biotechnology Conservation Processes: Similarities with Natural Long-Term Preservation of Biological Organisms

Philippe Abdel Sayed, Corinne Scaletta, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri, Laurent Alexis Clément Vannay, Alexis Laurent

Cryopreservation and lyophilization processes are widely used for conservation purposes in the pharmaceutical, biotechnological, and food industries or in medical transplantation. Such processes deal with extremely low temperatures (e.g., -196 degrees C) a ...

MDPI2023

A study model for reconstructing urban ecological niches

Francesco Mondada, Robert Matthew Mills

The Living Arch is a study model that was designed to showcase our ongoing research into bioactive architectural systems to be inhabited by honeybees. The arch is a synergistic combination of 3D printing and active mycelia growth, created for a museum exhi ...

CRC Press2022

Symbolic kinetic models in python (SKiMpy): intuitive modeling of large-scale biological kinetic models

Vassily Hatzimanikatis, Georgios Fengos, Maria Masid Barcon, Daniel Robert Weilandt, Zhaleh Hosseini, Pierre Guy Rémy Salvy

Motivation: Large-scale kinetic models are an invaluable tool to understand the dynamic and adaptive responses of biological systems. The development and application of these models have been limited by the availability of computational tools to build and ...

OXFORD UNIV PRESS2022

Monodisperse Selectively Permeable Hydrogel Capsules Made from Single Emulsion Drops

Esther Amstad, Alexandre Louis André Persat, Huachuan Du, Mathias Steinacher, Alice Cont

Capsules are often used to protect chemical and biological entities from the environment, to control the timing and location of their release, or to facilitate the collection of waste. Their performance depends on the thickness and composition of their she ...

2021

Quantification of Strand Accessibility in Biostable DNA Origami with Single-Staple Resolution

Maartje Martina Cornelia Bastings, Alice Comberlato

DNA-based nanostructures are actively gaining interest as tools for biomedical and therapeutic applications following the recent development of protective coating strategies prolonging structural integrity in physiological conditions. For tailored biologic ...

AMER CHEMICAL SOC2021

Wireless soft microscale actuators and robotic devices to study mechanobiology

Raquel Filipa Penacho Parreira

Tissues morphogenesis and homeostasis involve the spatiotemporal regulation of mechanics at multiple scales. Characterization of mechanical properties of biological systems as well as investigating the effects of mechanical forces on biological function ar ...

EPFL2021

Surprise-based model estimation in reinforcement learning: algorithms and brain signatures

Vasiliki Liakoni

Learning how to act and adapting to unexpected changes are remarkable capabilities of humans and other animals. In the absence of a direct recipe to follow in life, behaviour is often guided by rewarding and by surprising events. A positive or a negative o ...

EPFL2021

Using flow cytometry and light-induced fluorescence to characterize the variability and characteristics of bioaerosols in springtime in Metro Atlanta, Georgia

Athanasios Nenes

The abundance and speciation of primary biological aerosol particles (PBAP) is important for understanding their impacts on human health, cloud formation, and ecosystems. Towards this, we have developed a protocol for quantifying PBAP collected from large ...

Copernicus GmbH2020

Chemical Biology Gateways to Mapping Location, Association, and Pathway Responsivity

Yimon Aye, Xuyu Liu

Here we discuss, how by applying chemical concepts to biological problems, methods have been developed to map spatiotemporal regulation of proteins and small-molecule modulation of proteome signaling responses. We outline why chemical-biology platforms are ...

2019

Evaluation of a full-scale wastewater treatment plant upgraded with ozonation and biological post-treatments: Abatement of micropollutants, formation of transformation products and oxidation by-products

Urs von Gunten, Hansruedi Siegrist

To protect the ecosystem and drinking water resources in Switzerland and in the countries of the downstream catchments, a new Swiss water protection act entered into force in 2016 aiming to reduce the discharge of micropollutants from wastewater treatment ...

2018

Machine learning-based tools to model and to remove the off-target effect

François Fleuret

A RNA interference, also called a gene knockdown, is a biological technique which consists of inhibiting a targeted gene in a cell. By doing so, one can identify statistical dependencies between a gene and a cell phenotype. However, during such a gene inhi ...

Springer2017

A Microfluidic Biodisplay

Sebastian Maerkl, Francesca Volpetti, Ekaterina Emilova Petrova

Synthetically engineered cells are powerful and potentially useful biosensors, but it remains problematic to deploy such systems due to practical difficulties and biosafety concerns. To overcome these hurdles, we developed a microfluidic device that serves ...

American Chemical Society2017

PROPER: global protein interaction network alignment through percolation matching

Matthias Grossglauser, Seyed Hamed Hassani, Ehsan Kazemi, Hasan Pezeshgi Modarres

Background The alignment of protein-protein interaction (PPI) networks enables us to uncover the relationships between different species, which leads to a deeper understanding of biological systems. Network alignment can be used to transfer biological know ...

2016

Photonic Nanojet Array for Fast Detection of Single Nanoparticles in a Flow

Martinus Gijs, Matteo Cornaglia, Hui Yang

We detect by optical microscopy Au and fluorescent nanopartides (NPs) during their motion in water based medium, using an array of dielectric microspheres that are patterned in a microwell array template. The Microspheres act as lenses focusing the light o ...

American Chemical Society2015

Electrochemical sensing and imaging of biological samples

Alexandra Bondarenko

Implementation of analytical methods for biological samples (e.g. bacteria or mammalian cells) is of great importance for diagnosis and treatment of various diseases, as well as for environmental monitoring. However, analysing biological samples is a cumbe ...

EPFL2015

Importance of Toxicokinetics for lnterspecies Variation in Sensitivity to Chemicals

Kristin Schirmer

Interspecies variation in sensitivity to synthetic chemicals can be orders of magnitude large. Species traits causing the variation can be related to toxicokinetics (uptake, distribution, biotransformation, elimination) or toxicodynamics (interaction with ...

American Chemical Society2014

Sensing Acetylcholine and Anticholinesterase Compounds

Kai Johnsson, Alberto Schena

Acetylcholine is a key neurotransmitter, and anticholinesterase agents are essential compounds used as medical drugs, pesticides, and chemical warfare agents. A semisynthetic fluorescence-based probe for the direct, real-time detection of acetylcholine and ...

Wiley-Blackwell2013

Sample processing device with detachable slide

Martinus Gijs, Ata Tuna Ciftlik

A biological and chemical sample processing device that b. comprises a high pressure-resistant, shallow and wide area microfluidic chamber having at least one wall formed by a detachable slide containing samples such as immobilized entities, biological sam ...

2013