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Concept

Cure de désintoxication

Publications associées (29)

Immersive VR for upper-extremity rehabilitation in patients with neurological disorders: a scoping review

Silvestro Micera

Background Neurological disorders, such as stroke and chronic pain syndromes, profoundly impact independence and quality of life, especially when affecting upper extremity (UE) function. While conventional physical therapy has shown effectiveness in provid ...

BioMed Central2024

Context-Aware Monitoring of Hand Motor Primitives in Daily Life Activities: A Pathway to Objectively Assess Rehabilitation of Patients with Upper-Limb Neurological Impairment

Yasaman Izadmehr

The hands, our silent performers in daily life, face overwhelming challenges when neurological impairments disrupt the simple tasks that compose our daily symphony. This thesis unveils a comprehensive framework for the objective monitoring of upper-limb re ...

EPFL2024

Shared functional connectome fingerprints following ritualistic ayahuasca intake

Enrico Amico

The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such "fingerprints" persist under altered states of consciousness is unknown. Ayahuasca is a potent s ...

Academic Press Inc Elsevier Science2023

Combination of Neurotechnologies Towards Personalized Neurorehabilitation for Stroke Patients

Claudia Bigoni

"Ensure healthy lives and promote well-being for all at all ages" is the third sustainable development goal for the United Nations Agenda of 2030. This doctoral thesis fully embodied this objective by targeting stroke, a leading cause of death and disabili ...

EPFL2023

Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

Christoph Merten, Ngoc Hien Du

Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the right combination is challenging and would benefit from high-content, ...

Nature Research2022

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

Clinical value of assessing motor performance in postacute stroke patients

Kamiar Aminian, Anisoara Ionescu, Fabien Massé

Background Rehabilitative treatment plans after stroke are based on clinical examinations of functional capacity and patient-reported outcomes. Objective information about daily life performance is usually not available, but it may improve therapy personal ...

BioMed Central2021

Combining Optogenetic Stimulation and Motor Training Improves Functional Recovery and Perilesional Cortical Activity

Silvestro Micera

Background. An ischemic stroke is followed by the remapping of motor representation and extensive changes in cortical excitability involving both hemispheres. Although stimulation of the ipsilesional motor cortex, especially when paired with motor training ...

SAGE PUBLICATIONS INC2021

The various forms of sensorimotor plasticity following limb amputation and their link with rehabilitation strategies

Estelle Emeline Raffin

Limb amputation is characterized by complex and intermingled brain reorganization processes combining sensorimotor deprivation induced by the loss of the limb per se, and compensatory behaviors, such as the over-use of the intact or remaining limb. While a ...

2021

Two-step immobilization of metronidazole prodrug on TEMPO cellulose nanofibrils through thiol-yne click chemistry for in situ controlled release

David Lyndon Emsley, Jasmine Viger-Gravel

Nowadays, drug encapsulation and drug release from cellulose nanofibrils systems are intense research topics, and commercial grades of cellulose nanomaterials are currently available. In this work we present an ester-containing prodrug of metronidazole tha ...

ELSEVIER SCI LTD2021

Lack of effect on ambulation of dalfampridine-ER (4-AP) treatment in adult SMA patients

Brian Donal McCabe

SMA is a genetically determined motor system disorder that results in muscle weakness, selective motor neuron death, muscle atrophy, and impaired functional mobility. In SMA model systems, long-term treatment with 4-aminopyridine (4-AP) has been shown to i ...

PERGAMON-ELSEVIER SCIENCE LTD2020

A multimodal approach to capture post-stroke temporal dynamics of recovery

Dimitri Nestor Alice Van De Ville, Silvestro Micera, Martina Coscia, Elvira Pirondini, Nawal Noëlle Kinany, Christian Giang, Jenifer Cléa Miehlbradt, Camilla Pierella

Objective.Several training programs have been developed in the past to restore motor functions after stroke. Their efficacy strongly relies on the possibility to assess individual levels of impairment and recovery rate. However, commonly used clinical scal ...

2020

The role of the subgenual anterior cingulate cortex in dorsomedial prefrontal-amygdala neural circuitry during positive-social emotion regulation

Dimitri Nestor Alice Van De Ville, Frank Scharnowski, Yury Koush, Gwladys Rey

Positive-social emotions mediate one's cognitive performance, mood, well-being, and social bonds, and represent a critical variable within therapeutic settings. It has been shown that the upregulation of positive emotions in social situations is associated ...

Wiley2020

Allostery in Its Many Disguises: From Theory to Applications

Matthieu Wyart, Giulia Palermo, Jingshi Li, Riccardo Ravasio

Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, andmetabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mec ...

CELL PRESS2019

Virtual Reality as a Vehicle to Empower Motor-Cognitive Neurorehabilitation

Andrea Serino

In this paper, we advocate the combination of four key ingredients that we believe are necessary to design long-lasting effective treatments for neurorehabilitation: (i) motor-cognitive training, (ii) evidence-based neuroscience principles, in particular t ...

Frontiers Media2018

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives

Jacques Fellay, Nimisha Chaturvedi

Tuberculosis is an ancient human disease, estimated to have originated and evolved over thousands of years alongside modern human populations. Despite considerable advances in disease control, tuberculosis remains one of the world's deadliest communicable ...

2018

Non-invasive brain stimulation to enhance cognitive rehabilitation after stroke

Friedhelm Christoph Hummel, Maximilian Jonas Wessel, Laurijn Rianne Draaisma

Stroke is a main cause for long-term disability. Stroke symptoms cover various domains, e.g., motor, sensory, language, or other cognitive functions. In clinical practice and rehabilitation research, especially motor impairment attracts much attention. How ...

2020

Increasing upper limb training intensity in chronic stroke using embodied virtual reality: a pilot study

Olaf Blanke, José del Rocio Millán Ruiz, Andrea Serino, Gangadhar Garipelli, Thomas Schmidlin, Odile Hélène Chevalley

Background: Technology-mediated neurorehabilitation is suggested to enhance training intensity and therefore functional gains. Here, we used a novel virtual reality (VR) system for task-specific upper extremity training after stroke. The system offers inte ...

BioMed Central2017

Lactate release from astrocytes to neurons contributes to cocaine memory formation

Pierre Magistretti

The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons active ...

Wiley-Blackwell2016

A Bayesian view of doubly robust causal inference

Léo Raymond-Belzile

In causal inference the effect of confounding may be controlled using regression adjustment in an outcome model, propensity score adjustment, inverse probability of treatment weighting or a combination of these. Approaches based on modelling the treatment ...

Oxford University Press2016