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Concept

Méticilline

Publications associées (17)

Antimicrobial susceptibility testing with integrated photonic crystal optical tweezers

Nicolas Villa

The abusive use of antimicrobial drugs during the last eighty years has favoured the natural selection of resistant pathogens able to neutralise drugs efficiently. Nowadays, antimicrobial resistance contributes to millions of deaths yearly, threatens the e ...

EPFL2023

Antimicrobial susceptibility testing by measuring bacterial oxygen consumption on an integrated platform

Martinus Adela Maria Gijs, Thomas Lehnert

Cellular respiration is a fundamental feature of metabolic activity and oxygen consumption can be considered as a reliable indicator of bacterial aerobic respiration, including for facultative anaerobic bacteria like E. coli. Addressing the emerging global ...

ROYAL SOC CHEMISTRY2021

Microfluidic Platforms for the Study of Bacterial Metabolism and Antimicrobial Susceptibility Testing

Yang Liu

Fast spreading antimicrobial resistance (AMR) is an emerging major public health issue. New therapeutic and diagnostic paradigms must be implemented to counteract this evolution. In this respect, fast antimicrobial susceptibility testing (AST) plays an imp ...

EPFL2021

Recent advances on sputtered films with Cu in ppm concentrations leading to an acceleration of the bacterial inactivation

Juan Kiwi, Sami Rtimi

This review focuses on the acceleration of the bactericidal and fungicidal effects by uniform, adhesive Cu-based nanocomposites on textile and thin polymer surfaces. The acceleration of the bacterial inactivation kinetics mediated by Cu, TiO2/Cu and ZrO2-T ...

ELSEVIER2020

An experiment-informed signal transduction model for the role of the Staphylococcus aureus MecR1 protein in beta-lactam resistance

Matteo Dal Peraro, Luciano Andres Abriata

The treatment of hospital- and community-associated infections by methicillin-resistant Staphylococcus aureus (MRSA) is a perpetual challenge. This Gram-positive bacterium is resistant specifically to beta-lactam antibiotics, and generally to many other an ...

Springer Nature2019

Detection of bacteria

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Milica Jovic, Yingdi Zhu

A method for bacteria detection and the assessment of the antimicrobial susceptibility profile uses a bacterial viability assay based on combining a highly efficient affinity bacteria enrichment/ separation with an electrochemical redox interrogation measu ...

2019

Development of an AFM-based nanomotion detection device for microbiological samples

Wojciech Chomicki

The main goals of this thesis pertain to the development of a device capable of detecting microorganism viability through monitoring the oscillations of a microscopic cantilever transducer, to improve the presently used device and to attempt to explain in ...

EPFL2019

Mass Spectrometry Methods for Bacterial Infection Diagnosis and Cancer Analysis

Yingdi Zhu

Matrix-assisted laser desorption/ionisation (MALDI) time-of-flight (TOF) mass spectrometry is an important analytical tool in chemistry and biology. Bearing the advantages of easy-to-use, fast measurements and relatively simple data interpretation, MALDI-T ...

EPFL2019

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

Georg Fantner, John McKinney, Haig Alexander Eskandarian

In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unusual cr ...

ELIFE SCIENCES PUBLICATIONS LTD2018

Indoor Light Enhanced Photocatalytic Ultra-Thin Films on Flexible Non-Heat Resistant Substrates Reducing Bacterial Infection Risks

Sami Rtimi

Photocatalytic antibacterial sol-gel coated substrates have been reported to kill bacteria under light or in the dark. These coatings showed non-uniform distribution, poor adhesion to the substrate and short effective lifetime as antibacterial surfaces. Th ...

Mdpi Ag2017

Recent Developments in Accelerated Antibacterial Inactivation on 2D Cu-Titania Surfaces under Indoor Visible Light

César Pulgarin, Juan Kiwi, Sami Rtimi

This review focuses on Cu/TiO2 sequentially sputtered and Cu-TiO2 co-sputtered catalytic/photocatalytic surfaces that lead to bacterial inactivation, discussing their stability, synthesis, adhesion, and antibacterial kinetics. The intervention of TiO2, Cu, ...

Mdpi Ag2017

New antimicrobial surfaces and intravascular catheters for the prevention of healthcare-associated infections

Myriam Koumba Sarah Ballo

Healthcare-associated infections (HAIs) are an important health issue around the world. The consequences of HAIs incidence include prolonged hospital stays, increased resistance of microorganisms to antimicrobials, higher costs for health systems and for t ...

EPFL2017

Nanomechanical sensor applied to blood culture pellets: a fast approach to determine the antibiotic susceptibility against agents of bloodstream infections

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Petar Stupar

Objectives: The management of bloodstream infection, a life-threatening disease, largely relies on early detection of infecting microorganisms and accurate determination of their antibiotic susceptibility to reduce both mortality and morbidity. Recently we ...

2017

Bactericidal activity and mechanism of action of copper-sputtered flexible surfaces against multidrug-resistant pathogens

César Pulgarin, Juan Kiwi, Sami Rtimi, Myriam Koumba Sarah Ballo

Using direct current magnetron sputtering (DCMS), we generated flexible copper polyester surfaces (Cu-PES) and investigated their antimicrobial activity against a range of multidrug-resistant (MDR) pathogens including eight Gram-positive isolates (three me ...

Springer Verlag2016

Anti-microbial dendrimers against multidrug-resistant P. aeruginosa enhance the angiogenic effect of biological burn-wound bandages

Dominique Pioletti, Lee Ann Laurent-Applegate, Philippe Abdel Sayed, Paris Jafari

Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with signi cant morbidity ...

Nature Research2016

Comparison of Methods for Evaluation of the Bactericidal Activity of Copper-Sputtered Surfaces against Methicillin-Resistant Staphylococcus aureus

César Pulgarin, Juan Kiwi

Bacteria can survive on hospital textiles and surfaces, from which they can be disseminated, representing a source of health care-associated infections (HCAIs). Surfaces containing copper (Cu), which is known for its bactericidal properties, could be an ef ...

American Society for Microbiology2012

Common mechanistic features among metallo-β-lactamases: a computational study of Aeromonas hydrophila CphA enzyme

Matteo Dal Peraro, Andrea Cavalli

Metallo-β-lactamases (MβLs) constitute an increasingly serious clinical threat by giving rise to β-lactam antibiotic resistance. They accommodate in their catalytic pocket one or two zinc ions, which are responsible for the hydrolysis of β-lactams. Recent ...

2009