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Concept

Cellule de grille

Publications associées (21)

Changes in spatial self-consciousness elicit grid cell–like representation in the entorhinal cortex

Olaf Blanke, Hyeongdong Park, Baptiste Gauthier, Emanuela De Falco, Louis Philippe Albert, Hyukjun Moon

Grid cells in the entorhinal cortex (EC) encode an individual’s location in space, integrating both environmental and multisensory bodily cues. Notably, body-derived signals are also primary signals for the sense of self. While studies have demonstrated th ...

2024

Online interoperable resources for building hippocampal neuron models via the Hippocampus Hub

Felix Schürmann, Armando Romani

To build biophysically detailed models of brain cells, circuits, and regions, a data-driven approach is increasingly being adopted. This helps to obtain a simulated activity that reproduces the experimentally recorded neural dynamics as faithfully as possi ...

2023

Community-based reconstruction and simulation of a full-scale model of region CA1 of rat hippocampus

Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Werner Alfons Hilda Van Geit, Lida Kanari, Srikanth Ramaswamy, James Gonzalo King, Alexis Arnaudon, Ying Shi, András Ecker, Jean-Denis Georges Emile Courcol, Armando Romani, Pramod Shivaji Kumbhar, Judit Planas Carbonell, Michael Emiel Gevaert, Nadir Roman Guerrero, Liesbeth Maria L Vanherpe, Huanxiang Lu, Mohameth François Sy, Cristina Colangelo, Juan Bautista Hernando Vieites, Cyrille Pierre Henri Favreau, Genrich Ivaska, Anna-Kristin Kaufmann, Joni Henrikki Herttuainen, Elvis Boci, Vishal Sood, Thomas Brice Delemontex, Fabien Petitjean, Julian Martin Budd, Mustafa Kerem Kurban, Alberto Antonietti, Davide Bella, Pranav Rai

The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, i ...

2024

Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex

Olaf Blanke, Nathan Quentin Faivre, Hyeongdong Park, Baptiste Gauthier, Hyukjun Moon

Grid cells in entorhinal cortex (EC) encode an individual’s location in space and rely on environmental cues and self-motion cues derived from the individual’s body. Body-derived signals are also primary signals for the sense of self and based on integrate ...

2022

Bodily self and human grid cell-like activity: probing spatial representation with immersive virtual reality

Hyukjun Moon

Grid cells are place-modulated neurons that encode the location of an agent in space, relying on the integration of various sensorimotor signals from the body. Of note, the integration of those signals is also fundamental for the agent's conscious experien ...

EPFL2021

Dysmaturation Observed as Altered Hippocampal Functional Connectivity at Rest Is Associated With the Emergence of Positive Psychotic Symptoms in Patients With 22q11 Deletion Syndrome

Dimitri Nestor Alice Van De Ville, Maude Schneider, Daniela Maria Zöller, Farnaz Delavari

BACKGROUND: Hippocampal alterations are among the most replicated neuroimaging findings across the psychosis spectrum. Moreover, there is strong translational evidence that preserving the maturation of hippocampal networks in mice models prevents the progr ...

ELSEVIER SCIENCE INC2021

HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data

Eilif Benjamin Muller, Werner Alfons Hilda Van Geit, Armando Romani

Anatomically and biophysically detailed data-driven neuronal models have become widely used tools for understanding and predicting the behavior and function of neurons. Due to the increasing availability of experimental data from anatomical and electrophys ...

2021

Géohistoire de l'Albanie moderne. Une lecture des recensements de 1918 à 2011

Alain Nicolas Jarne

In this thesis, an original database is constituted, described and exploited in a geohistorical perspective, containing the registration of the population at the local level for the fifteen censuses conducted in Albania between 1918 and 2011. The precision ...

EPFL2020

Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans

Olaf Blanke

In mental time travel (MTT) one is "traveling" back-and-forth in time, remembering, and imagining events. Despite intensive research regarding memory processes in the hippocampus, it was only recently shown that the hippocampus plays an essential role in e ...

2018

Learning Neural Connectivity from Firing Activity: Scalable Algorithms with Provable Guarantees

Martin Vetterli, Amin Karbasi, Amir Hesam Salavati

The connectivity of a neuronal network has a major effect on its functionality and role. It is generally believed that the complex network structure of the brain provides a physiological basis for information processing. Therefore, identifying the network’ ...

Springer New York LLC2018

Vestibular modulation of peripersonal space boundaries

Olaf Blanke, Andrea Serino, Christian Pfeiffer

Human-environment interactions are mediated through the body and occur within the peripersonal space (PPS), the space immediately adjacent to and surrounding the body. The PPS is taken to be a critical interface between the body and the environment, and in ...

2018

Model-based reinforcement learning and navigation in animals and machines

Dane Sterling Corneil

For decades, neuroscientists and psychologists have observed that animal performance on spatial navigation tasks suggests an internal learned map of the environment. More recently, map-based (or model-based) reinforcement learning has become a highly activ ...

EPFL2018

Artificial spatiotemporal touch inputs reveal complementary decoding in neocortical neurons

Silvestro Micera

Investigations of the mechanisms of touch perception and decoding has been hampered by difficulties in achieving invariant patterns of skin sensor activation. To obtain reproducible spatiotemporal patterns of activation of sensory afferents, we used an art ...

Nature Research2017

A 16-Channel 1.1mm2 Implantable Seizure Control SoC with Sub-μW/Channel Consumption and Closed-Loop Stimulation in 0.18μm CMOS

Yusuf Leblebici, Alexandre Schmid, Mahsa Shoaran

We present a 16-channel seizure detection system-on-chip (SoC) with 0.92μW/channel power dissipation in a total area of 1.1mm² including a closed-loop neural stimulator. A set of four features are extracted from the spatially filtered neural data to achiev ...

IEEE2016

New Developments and Applications of the MP2RAGE Sequence - Focusing the Contrast and High Spatial Resolution R1 Mapping

Rolf Gruetter, José Pedro Rebelo Ferreira Marques

MR structural T1-weighted imaging using high field systems (>3T) is severely hampered by the existing large transmit field inhomogeneities. New sequences have been developed to better cope with such nuisances. In this work we show the potential of a recent ...

Public Library of Science2013

Rhythmic Modulation of Theta Oscillations Supports Encoding of Spatial and Behavioral Information in the Rat Hippocampus

Oscillatory patterns of activity in various frequency ranges are ubiquitously expressed in cortical circuits. While recent studies in humans emphasized rhythmic modulations of neuronal oscillations ("second-order" rhythms), their potential involvement in i ...

Elsevier2012

Complexity and performance in simple neuron models

Wulfram Gerstner, Richard Naud, Skander Mensi

The ability of simple mathematical models to predict the activity of single neurons is important for computational neuroscience. In neurons, stimulated by a time-dependent current or conductance, we want to predict precisely the timing of spikes and the su ...

2010

Is there a geometric module for spatial orientation? Insights from a rodent navigation model

Wulfram Gerstner, Ricardo Andres Chavarriaga Lozano, Thomas Strösslin

Modern psychological theories of spatial cognition postulate the existence of a geometric module for reorientation. This concept is derived from experimental data showing that in rectangular arenas with distinct landmarks in the corners, disoriented rats o ...

American Psychological Association2009

Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala

Pierre Magistretti, Igor Allaman

Accumulating evidence supports a role for brain-derived neurotrophic factor (BDNF) in depression. However, most of these studies have been performed in animal models that have a low face validity with regard to the human disease. Here, we examined the regu ...

2009

AMPA receptor imaging by infrared scanning near-field optical microscopy

Giorgio Margaritondo, Kai Johnsson, Harald Hirling, Johanna Generosi

Infrared scanning near-field optical microscopy is used to detect AMPA-type glutamate receptor clusters in hippocampal neuron cells. AMPA's GluR2-subunits were marked with the fluorophore Alexa488 and high-resolution micrographs were taken at 6.25 µm wavel ...

Wiley2008