Publications associées à Myofibrille

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

Bart Deplancke, Daniel Alpern, Julie Marie Russeil

Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth. How muscle growth is coordinated ...

2021

Active contraction of cardiac cells: a reduced model for sarcomere dynamics with cooperative interactions

Alfio Quarteroni, Francesco Regazzoni, Luca Dede'

We propose a reduced ODE model for the mechanical activation of cardiac myofilaments, which is based on explicit spatial representation of nearest-neighbour interactions. Our model is derived from the cooperative Markov Chain model of Washio et al. (Cell M ...

SPRINGER HEIDELBERG2018

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Giuseppe Schiavone, Florian Dylan Fallegger, Nicolas Vachicouras, Fabien Bertrand Paul Wagner, Xiaoyang Kang

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour ...

IEEE2018

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...

2018

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...

2018

Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure

Sandor Kasas

Loss of T-tubules (TT), sarcolemmal invaginations of cardiomyocytes (CMs), was recently identified as a general heart failure (HF) hallmark. However, whether IT per se or the overall sarcolemma is altered during HF process is still unknown. In this study, ...

Elsevier2014