Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Concept

Neovascularization

Publications associées (26)

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

Douglas Hanahan

Endothelial cells (ECs) in blood vessels under formation are stabilized by the recruitment of pericytes, both in normal tissues and during angiogenesis in pathologic situations, including neoplasia. In the tumor vasculature, besides supporting the function ...

2011

Proangiogenic Factor PlGF Programs CD11b(+) Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors

Tumor-mobilized bone marrow-derived CD11b(+) myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here, we show that CD11b(+) myelomonocytic cells develop proangiogenic properties ...

2011

Radiotherapy Suppresses Angiogenesis in Mice through TGF-beta RI/ALK5-Dependent Inhibition of Endothelial Cell Sprouting

Background: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are naturally considered the main target of radiotherapy, emerging evidence indicates that radiotherapy also affects endothelial cell functions, and possibly also ...

Public Library of Science2010

Biomechanical regulation of blood vessel growth during tissue vascularization

Formation of new vessels in granulation tissue during wound healing has been assumed to occur solely through sprouting angiogenesis. In contrast, we show here that neovascularization can be accomplished by nonangiogenic expansion of preexisting vessels. Us ...

2009

Stem cell-based cardiovascular tissue engineering

Cardiovascular diseases, including myocardial infarction, are the leading cause of death worldwide for both men and women. Current therapies are limited by the restricted intrinsic regeneration capacity of the heart and by the lack of organs for transplant ...

EPFL2009

Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2

Purpose: Apoptosis is known to play a key role in cell death after retinal ischemia. However, little is known about the kinetics of the signaling pathways involved and their contribution to this process. The aim of this study was to determine whether chang ...

2009