Axe intestin-cerveau

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Gastrointestinal disease

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Publications associées (28)

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The role of immune effectors in controlling Drosophila-microbes interactions

Alice Marra

All live beings are in constant interaction with microorganisms that may be beneficial, deleterious or commensal. Insects in particular live in close contact with microorganisms. This is especially true for species, like the fruit fly Drosophila melanogast ...

EPFL2021

C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy

Alessandra Griffa

Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic inflammation and brain microstructural changes (measured by diffusion-weighted imaging) in patients with COVID-19 ...

SPRINGER WIEN2021

Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

Cristina Ramona Cudalbu Moldovan, Veronika Rackayová, Jocelin Grosse, Emmanuelle Ines Flatt

Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora ...

Nature Research2021

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Johan Auwerx, Davide D'Amico, Pamela Solange Valdés Undurraga, Pénélope Andreux

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its ...

2021

Biogeography of microbial bile acid transformations along the murine gut

Rizlan Bernier-Latmani, Laure Menin, Solenne Anne Marie Marion, Lyne Desharnais

Bile acids, which are synthesized from cholesterol by the liver, are chemically transformed along the intestinal tract by the gut microbiota, and the products of these transformations signal through host receptors, affecting overall host health. These tran ...

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2020

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

Johan Auwerx, Giorgia Benegiamo

Asperuloside (ASP) is an iridoid glycoside that is extracted from Eucommia leaves. Eucommia is used in traditional Chinese medicine and has a long history of benefits on health and longevity. Here, we investigated the impact of ASP on obesity-related metab ...

2020

Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids

Xavier Fernandez-Real Girona

The gut microbiome has been linked to fear extinction learning in animal models. Here, we aimed to explore the gut microbiome and memory domains according to obesity status. A specific microbiome profile associated with short-term memory, working memory, a ...

Cell Press2020

Biogeography and biochemistry of bile acid 7-dehydroxylation in the mammalian gut

Solenne Anne Marie Marion

Bile acids (BAs) are small molecules synthesized by the host and chemically modified by the microorganisms inhabiting the intestinal tract. The microbial transformation of BAs in the gut is critical to BA-mediated signaling as it modifies their amount and ...

EPFL2020