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Concept

Viral phenomenon

Publications associées (18)

Peptide-based virucidal drugs

Francesca Olgiati

Before the COVID-19 pandemic, viruses were not a major priority for the scientific community. Today, many events have changed the world and the importance of studying viruses, vaccines, and antiviral drugs is fully appreciated. The development of effective ...

EPFL2024

The Impact of Data Persistence Bias on Social Media Studies

Tugrulcan Elmas

Social media studies often collect data retrospectively to analyze public opinion. Social media data may decay over time and such decay may prevent the collection of the complete dataset. As a result, the collected dataset may differ from the complete data ...

Assoc Computing Machinery2023

Toward biocontrol of waterborne pathogens: contributions of protists to virus removal and associated mechanisms

Margot Ninon Lauren Olive

Human viruses are widespread in the water environment and pose a risk to human health. Wastewater effluents represent the main source of viruses discharge in the environment, leading to contamination of aquatic ecosystems. Viral pathogens can persist on th ...

EPFL2022

Broad-Spectrum Antiviral Agents Based on Multivalent Inhibitors of Viral Infectivity

Francesco Stellacci

The ongoing pandemic of the coronavirus disease (Covid-19), caused by the spread of the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), highlights the need for broad-spectrum antiviral drugs. In this Essay, it is argued that such agents alrea ...

WILEY2021

Discovery and Further Studies on Giant Viruses at the IHU Mediterranee Infection That Modified the Perception of the Virosphere

Meriem Bekliz

The history of giant viruses began in 2003 with the identification of Acanthamoeba polyphaga mimivirus. Since then, giant viruses of amoeba enlightened an unknown part of the viral world, and every discovery and characterization of a new giant virus modifi ...

MDPI2019

A ligand-based system for receptor-specific delivery of proteins

Kai Johnsson, Luc Reymond

Gene delivery using vector or viral-based methods is often limited by technical and safety barriers. A promising alternative that circumvents these shortcomings is the direct delivery of proteins into cells. Here we introduce a non-viral, ligand-mediated p ...

Springer Nature2019

Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective

Jeffrey David Jensen, Susanne Petra Pfeifer, Kristen Kay Irwin, Cornelia Pokalyuk

Given the strong selective pressures often faced by populations when colonizing a novel habitat, the level of variation present on which selection may act is an important indicator of adaptive potential. While often discussed in an ecological context, this ...

Wiley2017

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

Jacques Fellay, Paul Jack Mc Laren, Istvan Bartha

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variat ...

Public Library of Science2017

Antiviral drug resistance as an adaptive process

Kristen Kay Irwin, Jeffrey David Jensen

Antiviral drug resistance is a matter of great clinical importance that, historically, has been investigated mostly from a virological perspective. Although the proximate mechanisms of resistance can be readily uncovered using these methods, larger evoluti ...

Oxford University Press2016

Limits and patterns of cytomegalovirus genomic diversity in humans

Jeffrey David Jensen, Cornelia Pokalyuk

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans. To address this deficiency, we analyzed genomic diversity among congeni ...

National Academy of Sciences2015

Evolution of the Influenza A Virus Genome during Development of Oseltamivir Resistance In Vitro

Jeffrey David Jensen

Influenza A virus (IAV) is a major cause of morbidity and mortality throughout the world. Current antiviral therapies include oseltamivir, a neuraminidase inhibitor that prevents the release of nascent viral particles from infected cells. However, the IAV ...

American Society for Microbiology2014

Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective

Jeffrey David Jensen, Matthieu Foll, Claudia Bank, Hyunjin Shim

Author Summary In recent years, considerable attention has been given to the evolution of drug resistance in the influenza A H1N1 strain. As a major annual cause of morbidity and mortality, combined with the rapid global spread of drug resistance, influenz ...

Public Library of Science2014

Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection

Jeffrey David Jensen

Populations of human cytomegalovirus (HCMV), a large DNA virus, are highly polymorphic in patient samples, which may allow for rapid evolution within human hosts. To understand HCMV evolution, longitudinally sampled genomic populations from the urine and p ...

Public Library of Science2013

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

Jacques Fellay, Paul Jack Mc Laren, Istvan Bartha

HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence ...

Elife Sciences Publications Ltd2013

Weighted Gossip: Distributed Averaging Using Non-Doubly Stochastic Matrices

Martin Vetterli, Patrick Thiran, Florence Bénézit

This paper presents a general class of gossip-based averaging algorithms, which are inspired from Uniform Gossip [1]. While Uniform Gossip works synchronously on complete graphs, weighted gossip algorithms allow asynchronous rounds and converge on any conn ...

IEEE2010

Outtweeting the Twitterers - Predicting Information Cascades in Microblogs

Karl Aberer, Zoran Despotovic, Dipanjan Chakraborty, Wojciech Galuba

Microblogging sites are a unique and dynamic Web 2.0 communication medium. Understanding the information flow in these systems can not only provide better insights into the underlying sociology, but is also crucial for applications such as content ranking, ...

2010

Application of broad-spectrum resequencing microarray for genotyping rhabdoviruses

Stewart Cole

The rapid and accurate identification of pathogens is critical in the control of infectious disease. To this end, we analyzed the capacity for viral detection and identification of a newly described high-density resequencing microarray (RMA), termed Pathog ...

American Society for Microbiology2010

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease

Patrick Aebischer, Nicole Déglon

The ability to regulate gene expression constitutes a prerequisite for the development of gene therapy strategies aimed at the treatment of neurologic disorders. In the present work, we used tetracycline (Tet)-regulated lentiviral vectors to investigate th ...

2002