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Concept

Maladie de König

Publications associées (21)

Morphological assessment of cartilage and osteoarthritis in clinical practice and research: Intermediate-weighted fat-suppressed sequences and beyond

Tom Hilbert

Magnetic resonance imaging (MRI) is widely regarded as the primary modality for the morphological assessment of cartilage and all other joint tissues involved in osteoarthritis. 2D fast spin echo fat-suppressed intermediate-weighted (FSE FS IW) sequences w ...

SPRINGER2023

Overcorrected Implants for Total Shoulder Arthroplasty

Yasmine Boulanaache

Glenohumeral osteoarthritis is a degenerative shoulder joint disease, which causes the breakdown of articular cartilage and bone. People affected by this disease suffer from severe pain and eventually reduced mobility and poor life quality. This disease is ...

EPFL2021

Development of Standardized Fetal Progenitor Cell Therapy for Cartilage Regenerative Medicine: Industrial Transposition and Preliminary Safety in Xenogeneic Transplantation

Dominique Pioletti, Corinne Scaletta, Sandra Jaccoud, Philippe Abdel Sayed, Nathalie Hirt-Burri, Salim Elias Darwiche

Diverse cell therapy approaches constitute prime developmental prospects for managing acute or degenerative cartilaginous tissue affections, synergistically complementing specific surgical solutions. Bone marrow stimulation (i.e., microfracture) remains a ...

2021

Tailoring the Mechanical Properties of Tissue Engineering Scaffolds made from Decellularized Cartilage

Jens Antons

Due to its limited regeneration capacity, articular cartilage defects are considered a frequent clinical problem. Initial cartilage defects, if left untreated, will progress in severity over time and can eventually lead to degenerative joint diseases such ...

EPFL2019

Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation

Goran Lovric

Early degenerative changes of articular cartilage are detected using contrast-enhanced computed tomography (CT) with a cationic contrast agent (CA). However, cationic CA diffusion into degenerated cartilage decreases with proteoglycan depletion and increas ...

2020

Relationships between cartilage thickness and subchondral bone mineral density in non-osteoarthritic and severely osteoarthritic knees: In vivo concomitant 3D analysis using CT arthrography

Julien Favre, Brigitte Jolles-Haeberli

Objective: To test whether subchondral bone mineral density (sBMD) and cartilage thickness (CTh) of femoral condyles are correlated in knees without and with severe medial femorotibial osteoarthritis (OA), using a subregional analysis with computerized tom ...

ELSEVIER SCI LTD2019

Modeling knee osteoarthritis pathophysiology using an integrated joint system (IJS): a systematic review of relationships among cartilage thickness, gait mechanics, and subchondral bone mineral density

Julien Favre, Brigitte Jolles-Haeberli

Objective: To introduce an integrated joint system (IJS) model of joint health and osteoarthritis (OA) pathophysiology through a systematic review of the cross-sectional relationships among three knee properties (cartilage thickness, gait mechanics, and su ...

ELSEVIER SCI LTD2018

Depth-dependent mechanical properties of human articular cartilage obtained by indentation measurements

Pierre-Etienne Bourban, Lee Ann Laurent-Applegate, Matteo Gregorio Modesto Marascio, Robin Martin, Jens Antons

Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is li ...

2018

Cement stress predictions after anatomic total shoulder arthroplasty are correlated with preoperative glenoid bone quality

Alexandre Terrier, Alain Farron, Raphaël Rodolphe Obrist

Hypothesis: We hypothesized that biomechanical parameters typically associated with glenoid implant failure after anatomic total shoulder arthroplasty (aTSA) would be correlated with preoperative glenoid bone quality. Methods: We developed an objective aut ...

Elsevier2017

Quantitative regional and sub-regional analysis of femoral and tibial subchondral bone mineral density (sBMD) using computed tomography (CT): comparison of non-osteoarthritic (OA) and severe OA knees

Julien Favre, Brigitte Jolles-Haeberli

Objective: This study aimed to compare subchondral bone mineral density (sBMD) between non-radiographic osteoarthritic (OA) and medial femorotibial OA knees, using computed tomography (CT). Design: CT exams from 16 non-radiographic OA (KL grade < 2) and 16 ...

Elsevier Sci Ltd2017

Mechanical evaluation of a tissue-engineered zone of calcification in a bone-hydrogel osteochondral construct

Dominique Pioletti, Alexandre Terrier, Jérôme Hollenstein

The objective of this study was to test the hypothesis that mechanical properties of artificial osteochondral constructs can be improved by a tissue-engineered zone of calcification at the bone-hydrogel interface. Experimental push-off tests were performed ...

Taylor & Francis2015

Strategies for improving the repair of focal cartilage defects

Dominique Pioletti, Philippe Abdel Sayed

Articular cartilage, together with skin, was predicted to be one of the first tissues to be successfully engineered. However cartilage repair remains nowadays still elusive, as we are still not able to overcome the hurdles of creating biomaterials correspo ...

Future Medicine Ltd2015

Effect of Patient Specific Parameters on Degenerative Shoulder Diseases

Christoph Anselm Engelhardt

Osteoarthritis and rotator cuff tears are two common and wide spread shoulder diseases leading to significant restrictions in the daily life of the affected. The pathogenesis is not fully understood yet. A chronic process triggered by multiple causes is as ...

EPFL2015

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

Dominique Pioletti, Philippe Abdel Sayed, Mohamadreza Nassajian Moghadam

Metabolism of proteoglycans and hyaluronic acid has been shown to be temperature- dependent in cartilage explants, with optimal anabolic effects between 36 1C and 38 1C. At rest, the temperature of human knee has a value of around 33 1C. We aim to show in ...

Elsevier2014

Dissipation as variable in cartilage mechanobiology

Philippe Abdel Sayed

Mechanobiology is the analysis of the role of mechanical forces in educing a molecular response in cells. Nowadays, mechanobiology may contribute to clinical progress. In particular, mechanical stimulation has been proposed to induce chondrogenesis in engi ...

EPFL2013

Hybrid Polymer Foams for Osteochondral Tissue Engineering

Matthieu Cuénoud

Articular cartilage is a soft tissue that covers the ends of articulating bones, and is essential for maintaining joint motion, i.e. translation and rotation between the bones. Articular cartilage nevertheless has a limited capacity for self-repair, and ca ...

EPFL2012

Total shoulder arthroplasty: Downward inclination of the glenoid component to balance supraspinatus deficiency

Dominique Pioletti, Alexandre Terrier, Alain Farron, Francesco Merlini

Hypothesis: Supraspinatus deficiency associated with total shoulder arthroplasty (TSA) provokes eccentric loading and may induce loosening of the glenoid component. A downward inclination of the glenoid component has been proposed to balance supraspinatus ...

2009

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...

EPFL2009

A new ambulatory system for comparative evaluation of the three-dimensional knee kinematics, applied to anterior cruciate ligament injuries

Kamiar Aminian, Julien Favre, Bijan Najafi

The aim of this study was to develop an ambulatory system for the three-dimensional (3D) knee kinematics evaluation, which can be used outside a laboratory during long-term monitoring. In order to show the efficacy of this ambulatory system, knee function ...

Springer-Verlag2006

Engineering of human meniscus substitute

Anna Marsano

Injuries to the meniscus are often treated by partial or total meniscectomy, which is known to be associated with detrimental changes in joint function, ultimately increasing the risk of early degenerative joint diseases. Surgical approaches currently in u ...

EPFL2006