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Publications associées (24)

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Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

Henry Markram, Tania Rinaldi, Karina Kulangara

Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but underlyin ...

National Academy of Sciences2007

Layer- and column-specific knockout of NMDA receptors in pyramidal neurons of the mouse barrel cortex

Carl Petersen

Viral vectors injected into the mouse brain offer the possibility for localized genetic modifications in a highly controlled manner. Lentivector injection into mouse neocortex transduces cells within a diameter of approximately 200mum, which closely matche ...

Frontiers Research Foundation2007

Ru(II), Os(II) and RH(III) complexes of PTA : their reactivity towards nucleotides and oligonucleotides

Antoine Dorcier

A series of ruthenium, osmium and rhodium complexes utilizing pta, (1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane) and pta-Me+, its N-methyl derivative, have been synthesized. Their characterization by 1H and 31P NMR spectroscopy, ESI-MS and single crysta ...

EPFL2006

Altered neocortical microcircuitry in the valproic acid rat model of autism

Tania Rinaldi

Autism is a wide-spectrum disorder with early childhood onset, affecting general cognitive capabilities and, in particular, complex information processing. Although interesting directions of research start to appear, the precise causes of the disorder and ...

EPFL2006