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Concept

Biologie médicale

Publications associées (28)

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

Hilal Lashuel, Anass Chiki, Sean Michael Deguire

Posttranslational modifications can have profound effects on the biological and biophysical properties of proteins associated with misfolding and aggregation. However, their detection and quantification in clinical samples and an understanding of the mecha ...

2017

Microfluidic staining technology and automated image processing for fast and accurate tissue-based diagnostics

Diego Gabriel Dupouy

The development of microfluidics has led to significant improvements in many areas of in vitro diagnostics. This thesis proposes the use of microfluidic device technology in the field of anatomic pathology, leading to faster and more accurate tissue-based ...

EPFL2016

Extra short incubation microfluidic assisted – fluorescence in situ hybridization (ESIMA-FISH)

Martinus Adela Maria Gijs, Raphaël Etienne Jean Trouillon, Huu Tuan Nguyen, Estelle Annick Cuttaz

Fluorescence in situ hybridization (FISH) is a powerful technique for evaluating the HER2 gene status in breast cancer specimen (1). However, most of FISH assays currently used in clinical laboratories are expensive and require long experimental time, up t ...

2016

Explaining the length threshold of polyglutamine aggregation

Paolo De Los Rios, Marc Hafner

The existence of a length threshold, of about 35 residues, above which polyglutamine repeats can give rise to aggregation and to pathologies, is one of the hallmarks of polyglutamine neurodegenerative diseases such as Huntington's disease. The reason why s ...

2012

Application of broad-spectrum resequencing microarray for genotyping rhabdoviruses

Stewart Cole

The rapid and accurate identification of pathogens is critical in the control of infectious disease. To this end, we analyzed the capacity for viral detection and identification of a newly described high-density resequencing microarray (RMA), termed Pathog ...

American Society for Microbiology2010

Experimental Characterization of Pressure Wave Generation and Propagation in Biological Tissues

Marcel Donnet, Mathieu Benoit, Kossi Agbeviade, Jacques Giovanola

Aim of the study: This work develops a measurement technique for pressure waves in soft tissues. It aims at characterizing, understanding and modeling the generation and propagation of pressure waves in soft tissues, with a view towards medical application ...

Springer, 233 Spring Street, New York, Ny 10013, United States2009

Oxidative stress on biomaterials : from molecules to cells

Reactive Oxygen Species (ROS) is a family of oxygen-based active molecules, which are deeply involved in numerous crucial processes of cellular metabolism, where the redox equilibrium is very important. An imbalance between ROS and the cell ability to neut ...

EPFL2006

Statistical and experimental analysis of quantitative PCR

Yann Karlen

Quantitative PCR (qPCR) is a powerful technique that is now commonly used in many research and clinical laboratories. Although it allows precise quantification of specific DNA sequences, it is often not used at its full potential. A number of data collecti ...

EPFL2005