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Concept

Index thérapeutique

Publications associées (32)

A wearable electrochemical sensing system for non-invasive monitoring of lithium drug in bipolar disorder

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Criscuolo

Lithium represents the main drug for the treatment of Bipolar Disorder (BD) as it acts as a mood stabilizer. However, because of its narrow therapeutic window, psychiatric patients are obliged to frequent tests in hospital to control their lithium blood co ...

2021

Directional Local Field Potentials in the Subthalamic Nucleus During Deep Brain Implantation of Parkinson's Disease Patients

André Mercanzini

Segmented deep brain stimulation leads feature directional electrodes that allow for a finer spatial control of electrical stimulation compared to traditional ring-shaped electrodes. These segmented leads have demonstrated enlarged therapeutic windows and ...

2020

Establishment of a Therapeutic Ratio for Gamma Knife Radiosurgery of Trigeminal Neuralgia: The Critical Importance of Biologically Effective Dose Versus Physical Dose

Constantin Tuleasca, Adrien Jean Régis Maurice Hilaire

OBJECTIVE: How variations of treatment time affect the safety and efficacy of Gamma Knife (GK) radiosurgery is a matter of considerable debate. With the relative simplicity of treatment planning for trigeminal neuralgia (TN), this question has been address ...

2020

Wearable multifunctional sweat-sensing system for efficient healthcare monitoring

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Criscuolo, Nicolò Oliva, Mandresy Ivan Ny Hanitra, Simone Aiassa

Despite the huge expansion in recent years of sweat sensing and wearable technologies, several challenges are still open, including poor sample collection, separate sampling and analysis, low multi-sensing capabilities and materials toxicity. In this work, ...

Elsevier2020

Wearable multi-electrode platform for ion sensing

Francesca Criscuolo

With the growth of personalized medicine and e-Health, there has been an increasing interest in the development of accurate sensing systems able to support this healthcare revolution for both in- and off-hospital monitoring. Remote biosensing devices can d ...

EPFL2020

Continuous monitoring of propofol in human serum with fouling compensation by support vector classifier

Giovanni De Micheli, Sandro Carrara, Danilo Demarchi, Francesca Criscuolo, Simone Aiassa, Francesco Grassi, Mandresy Ivan Ny Hanitra, Tiberiu Totu

We present a new method for electrochemical sensing, which compensates the fouling effect of propofol through machine learning (ML) model. Direct and continuous monitoring of propofol is crucial in the development of automatic systems for control of drug i ...

Elsevier2020

Chemistry and Analysis of Nanoparticle-Modified Living Cells

Tanja Thomsen

Conventional therapeutics are often limited by their targeting ability, resulting in harmful and potential fatal side-effects for the patients. Recently, new strategies have been developed to improve target specificity of drugs in order to generate more ef ...

EPFL2020

Photocontrolled release of the anticancer drug chlorambucil with caged harmonic nanoparticles

Sandrine Gerber, Luigi Bonacina, Raphaël Jovita De Matos, Jérémy Vuilleumier

While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy ...

Wiley-VHCA AG2020

Impact of the skull contour definition on Leksell Gamma Knife(R)Icon (TM) radiosurgery treatment planning

Constantin Tuleasca

Introduction The Gamma Knife(R)planning software (TMR 10, Elekta Instruments, AB, Sweden) affords two ways of defining the skull volume, the "historical" one using manual measurements (still perform in some centers) and the new one using image-based skull ...

2020

Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus

Philippe Renaud, André Mercanzini

Objective Segmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the volume ...

PUBLIC LIBRARY SCIENCE2019

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. "Alive, with good vision and no comorbidity"

Paul Joseph Dyson

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic ap ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development

Raphael Christopher Sommer

Worldwide, tuberculosis (TB) is the leading cause of death due to a single infectious agent, claiming 1.6 million human lives and causing >10 million new cases in 2017 alone, mostly in low-income regions. The intracellular pathogen Mycobacterium tuberculos ...

EPFL2019