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Concept

Triple hélice

Publications associées (6)

Kinetically Trapped Liquid-State Conformers of a Sodiated Model Peptide Observed in the Gas Phase

Thomas Rizzo, Chiara Masellis, Markus Schneider

We investigate the peptide AcPheAla(5)Lyar(+), a model system for studying helix formation in the gas phase, in order to fully understand the forces that stabilize the helical structure. In particular, we address the question of whether the local fixation ...

2017

Structure and Biophysical Properties of a Triple-Stranded Beta-Helix Comprising the Central Spike of Bacteriophage T4

Laure Menin, Petr Leiman, Sergii Buth

Gene product 5 (gp5) of bacteriophage T4 is a spike-shaped protein that functions to disrupt the membrane of the target cell during phage infection. Its C-terminal domain is a long and slender -helix that is formed by three polypeptide chains wrapped aroun ...

Mdpi Ag2015

Living in interesting times : an urban view from Beijing innovators

Béatrice Ferrari

Interactions of transmembrane (TM) helices play a key role in many cell processes. The configuration and cross angle these helices adopt are traditionally attributed to specific residue interactions. We present a different approach, in which specific resid ...

EPFL2013

Fine DNA structure revealed by constant height frequency modulation AFM imaging

Giovanni Dietler, Dusan Vobornik, Andrea Cerreta

Few examples of sub nanometer resolution on biomolecules can be found in literature. In particular, AFM experiments on DNA mostly fail to show the double helical groove periodicity, and so far such a feat was only achieved in liquid. Here we describe a met ...

Elsevier2013

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

Joachim Lingner, Sophie Redon, Ivo Zemp

Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of telomeric heterochromatin. In vitro, naked TERRA molecules are efficient inhibitor ...

Oxford University Press2013

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...

EPFL2009