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Publications associées (26)

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Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation

Silvestro Micera

Objective. The vestibular system provides essential information about balance and spatial orientation via the brain to other sensory and motor systems. Bilateral vestibular loss significantly reduces quality of life, but vestibular implants (VIs) have demo ...

Iop Publishing Ltd2016

Genetic dissection of the role of BMP signaling for the development of the auditory brainstem nuclei and the large calyx of Held synapse

Elin Kristina Kronander

Synapses are key elements for communication within the complex network of neurons that make up our brain. Interestingly, synaptic connections can differ greatly in form and function, depending on the specific circuit into which they are embedded. In this P ...

EPFL2016

Conducting polymer electrodes for auditory brainstem implants

Stéphanie Lacour, Nicolas Vachicouras, Amélie Anne Guex

The auditory brainstem implant (ABI) restores hearing in patients with damaged auditory nerves. One of the main ideas to improve the efficacy of ABIs is to increase spatial specificity of stimulation, in order to minimize extra-auditory side-effects and to ...

Royal Society of Chemistry2015

Tmc gene therapy restores auditory function in deaf mice

Patrick Aebischer, Bernard Schneider, Cylia Cloé Rochat

Genetic hearing loss accounts for up to 50% of prelingual deafness worldwide, yet there are no biologic treatments currently available. To investigate gene therapy as a potential biologic strategy for restoration of auditory function in patients with genet ...

American Association for the Advancement of Science2015

Precise toxigenic ablation of intermediate cells abolishes the "battery" of the cochlear duct

Friedrich Beermann

The extracellular potential of excitable and nonexcitable cells with respect to ground is ∼0 mV. One of the known exceptions in mammals is the cochlear duct, where the potential is ∼80-100 mV, called the endocochlear potential (EP). The EP serves as the "b ...

Society for Neuroscience2013

Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons

Ralf Schneggenburger, Olexiy Kochubey, Yunyun Han, Le Xiao, Heather Mary Elizabeth Murray

The large glutamatergic calyx of Held synapse in the auditory brainstem has become a powerful model for studying transmitter release mechanisms, but the molecular bases of presynaptic function at this synapse are not well known. Here, we have used single-c ...

2010