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Concept

Robustesse (évolution)

Publications associées (28)

A Statistical Guide to the Design of Deep Mutational Scanning Experiments

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski

The characterization of the distribution of mutational effects is a key goal in evolutionary biology. Recently developed deep-sequencing approaches allow for accurate and simultaneous estimation of the fitness effects of hundreds of engineered mutations by ...

Genetics Society America2016

On the (un) predictability of a large intragenic fitness landscape

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski

The study of fitness landscapes, which aims at mapping genotypes to fitness, is receiving ever-increasing attention. Novel experimental approaches combined with next-generation sequencing (NGS) methods enable accurate and extensive studies of the fitness e ...

National Academy of Sciences2016

Stabilizing patterning in the Drosophila segment polarity network by selecting models in silico

Felix Naef, Jacques Rougemont, Mirko Bischofberger

The segmentation of Drosophila is a prime model to study spatial patterning during embryogenesis. The spatial expression of segment polarity genes results from a complex network of interacting proteins whose expression products are maintained after success ...

Elsevier2010

Positive feedback in the transition from sexual reproduction to parthenogenesis

Séverine Vuilleumier Varisco

Understanding how new phenotypes evolve is challenging because intermediate stages in transitions from ancestral to derived phenotypes often remain elusive. Here we describe and evaluate a new mechanism facilitating the transition from sexual reproduction ...

2010

Stress, genotype and norepinephrine in the prediction of mouse behavior using reinforcement learning

Maria del Carmen Sandi Perez, Wulfram Gerstner, Gediminas Luksys

Individual behavioral performance during learning is known to be affected by modulatory factors, such as stress and motivation, and by genetic predispositions that influence sensitivity to these factors. Despite numerous studies, no integrative framework i ...

Nature Publishing Group2009

Evolutionary reverse engineering of gene networks

Daniel Marbach

The expression of genes is controlled by regulatory networks, which perform fundamental information processing and control mechanisms in a cell. Unraveling and modelling these networks will be indispensable to gain a systems-level understanding of biologic ...

EPFL2009

Extracellular polymeric substances affecting pore-scale hydrologic conditions for bacterial activity in unsaturated soils

Dani Or

Soil bacterial cells are often found embedded in biosynthesized extracellular polymeric substances ( EPS) forming aggregates or stationary colonies attached to solid surfaces. Soil bacterial aggregation and pooling of resources offer a successful adaptatio ...

2007

Fast directed evolution of non-immunoglobulin proteins by somatic hypermutation in immune cells

Kai Johnsson, Christian Heinis

A review. New, improved phenotypes. Somatic hypermutation in immune cells can be used for the fast directed evolution of proteins other than Igs (e.g., autofluorescent proteins). The target gene is inserted into the genome of activated B lymphocytes where ...

2005