Toxicokinetic-toxicodynamic (TKTD) models quantify the time-course of internal concentration, which is defined by uptake, elimination and biotransformation (TK), and the processes which lead to the toxic effects (TD). TKTD models show potential in predicti ...
We describe certain extremality properties for Gallager's reliability function E-0 for binary input symmetric DMCs. In particular, we show that amongst such DMC's whose E-0(rho(1)) has a given value for a given rho(1), the BEC and BSC have the largest and ...