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Concept

Fluorodésoxyglucose (18F)

Publications associées (28)

Direct mapping of 19F in 19FDG-6P in brain tissue at subcellular resolution using soft X-ray fluorescence

Rolf Gruetter, Carole Poitry-Yamate

Low energy x-ray fluorescence (LEXRF) detection was optimized for imaging cerebral glucose metabolism by mapping the fluorine LEXRF signal of 19 F in 19 FDG, trapped as intracellular 19 F-deoxyglucose-6-phosphate ( 19 FDG-6P) at 1μm spatial resolution from ...

IOP Publishing2013

Brain Glucose Transport and Phosphorylation Under Acute Insulin-Induced Hypoglycemia in Mice: An 18F-FDG PET Study

Rolf Gruetter, João Miguel das Neves Duarte, Malte Alf

We addressed the questions of how cerebral glucose transport and phosphorylation change under acute hypoglycemia and what the underlying mechanisms of adaptation are. Methods: Quantitative 18F-FDG PET combined with the acquisition of real-time arterial inp ...

2013

Mathematical Modeling of Brain Energy Metabolism, Measured with PET and MRS in Rodents

Bernard Lanz

Positron emission tomography (PET) and nuclear magnetic resonance spectroscopy (MRS) are two biomedical measurement techniques developed in the end of the XXth century, which drastically improved the amount of accessible information available in vivo. PET ...

EPFL2012

Fluorine-18 labeling of three novel D-peptides by conjugation with N-succinimidyl-4-[F-18]fluorobenzoate and preliminary examination by postmortem whole-hemisphere human brain autoradiography

Andrea Pfeifer

Introduction: beta-Amyloid (A beta) plaques and neurofibrillary tangles are the main characteristics of Alzheimer's disease (AD). Positron emission tomography (PET), a high-resolution, sensitive, and noninvasive imaging technique, has been widely utilized ...

2012

Uptake of Fluoride from Aqueous Solution on Nano-Sized Hydroxyapatite: Examination of a Fluoridated Surface Layer

Janet Gordon Hering

Hydroxyapatite (Ca-10(PO4)(6)(OH)(2), HAP), both as a synthetic material and as a constituent of bone char, can serve as an effective and relatively inexpensive filter material for fluoride (F-) removal from drinking water in low-income countries. Fluoride ...

2012

Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography

Rolf Gruetter, Bernard Lanz, Carole Poitry-Yamate, Hans-Anton Lehr

3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[F-18]fluoro-d-glucose ([F-18]FDG) but less sensitive. We studied the capaci ...

Elsevier2011

In Vivo Evidence for Lactate as a Neuronal Energy Source

Pierre Magistretti, Renaud Jolivet

Cerebral energy metabolism is a highly compartmentalized and complex process in which transcellular trafficking of metabolites plays a pivotal role. Over the past decade, a role for lactate in fueling the energetic requirements of neurons has emerged. Furt ...

2011

A Handheld Probe for beta(+)-Emitting Radiotracer Detection in Surgery, Biopsy and Medical Diagnostics based on Silicon Photomultipliers

Edoardo Charbon, Claudio Bruschini, Christian Mester

We present a new, handheld probe for radiotracer detection in vivo and inside operating theatres, where PET scanners cannot be used for radioguided surgery. The device is based on scintillation detectors optically coupled to Silicon Photomultipliers (SiPMs ...

Ieee2011