Concept

Cancer-related fatigue

Publications associées (28)

Mechanism of KRAS-driven T cell infiltration in colorectal cancer

Colorectal cancer is the second-leading cause of cancer death worldwide. Early-stage disease can be detected with preventative medical screening and is treatable with surgical resection. Sixty-percent of patients, however, are diagnosed with advanced-stage ...

EPFL2023

Effect of fiber architecture on tension-tension fatigue behavior of bolted basalt composite joints

Thomas Keller, Lulu Liu

The effect of fiber architecture, i.e., unidirectional (UD) vs. multi-directional (MD), on the tension-tension fa-tigue behavior of bolted double-lap basalt composite joints was experimentally investigated. The fatigue load-life (F -N) curves of MD and UD ...

ELSEVIER SCI LTD2023

Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma

Paul Joseph Dyson, Valentin Simeonov, Fabien Kuttler, Patrik Aouad, Irina Sinenko

Retinoblastoma is the most common pediatric eye cancer. It is currently treated with a limited number of drugs, adapted from other pediatric cancer treatments. Drug toxicity and relapse of the disease warrant new therapeutic strategies for these young pati ...

WILEY2023

Multiomic analysis of HER2-enriched and AR-positive breast carcinoma with apocrine differentiation and an oligometastatic course: a case report

Andrea Cavalli

Breast carcinoma is the most prevalent cancer among women globally. It has variable clinical courses depending on the stage and clinical-biological features. This case report describes a 56-year-old female with invasive breast cancer without estrogen or pr ...

FRONTIERS MEDIA SA2023

Concurrent Evolution of Biomechanical and Physiological Parameters With Running-Induced Acute Fatigue

Kamiar Aminian, Anisoara Ionescu, Salil Apte, Gaëlle Prigent

Understanding the influence of running-induced acute fatigue on the homeostasis of the body is essential to mitigate the adverse effects and optimize positive adaptations to training. Fatigue is a multifactorial phenomenon, which influences biomechanical, ...

FRONTIERS MEDIA SA2022

Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy

Kewen Lei

Cancer is one of the leading causes of death globally. Immunotherapy represents one of the most promising cancer treatments inducing complete and durable responses in a fraction of cancer patients. Despite the unprecedented clinical success achieved by T c ...

EPFL2022

Augmented Cooper test: Biomechanical contributions to endurance performance

Kamiar Aminian, Salil Apte

Running mechanics are modifiable with training and adopting an economical running technique can improve running economy and hence performance. While field measurement of running economy is cumbersome, running mechanics can be assessed accurately and conven ...

FRONTIERS MEDIA SA2022

Hardware and Software Interfaces Design for Multi-Panel Electrochemical Sensors

Mandresy Ivan Ny Hanitra

The exponential growth of wearable healthcare devices market is fostered by the internetof- things (IoT) era. Connected smart biosensors enable a decentralized healthcare that does not constrain the user to be in a medical facility to get a real-time insig ...

EPFL2021

Fatigue of reinforced UHPFRC members and monitoring of fatigue action effects on bridges

Bartlomiej Wojciech Sawicki

The objective of this thesis is to develop knowledge and methods to prevent fatigue failure of bridges. The Fatigue Limit State is investigated from both the demand (S) and resistance (R) side. The S-part focuses on reduction of uncertainties through monit ...

EPFL2021

Role of mean stress on fatigue behavior of a 316L austenitic stainless steel in LWR and air environments

Philippe Spätig, Hans-Peter Seifert

Mean stress effects on fatigue life of a stainless steel in air and boiling water reactor (BWR) environments were evaluated by load-controlled tests. In stress-life, non-zero mean stresses increase life in low cycle fatigue regime in both environments and ...

ELSEVIER SCI LTD2021

Fatigue Performance of an Additively Manufactured Zr-Based Bulk Metallic Glass and the Effect of Post-Processing

Roland Logé, Jamasp Jhabvala, Navid Sohrabi, Milad Hamidi Nasab, Annapaola Parrilli, Baptiste Thomas Jean Rouxel

Fatigue is the most common cause of failure of mechanical parts in engineering applications. In the current work, we investigate the fatigue life of a bulk metallic (BMG) glass fabricated via additive manufacturing. Specimens fabricated via laser powder-be ...

MDPI2021

A novel fatigue life prediction methodology based on energy dissipation in viscoelastic materials

Thomas Keller, Ghazaleh Eslami

This paper introduces a new fatigue life prediction methodology for viscoelastic materials in the tension-tension fatigue loading region. The model was established based on the total amount of energy dissipated during fatigue loading, and offers two main a ...

ELSEVIER SCI LTD2021

Advanced technological tools to study multidrug resistance in cancer

Sandor Kasas

The complexity of cancer biology and its clinical manifestation are driven by genetic, epigenetic, transcriptomic, proteomic and metabolomic alterations, supported by genomic instability as well as by environmental conditions and lifestyle factors. Althoug ...

CHURCHILL LIVINGSTONE2020

The history of fiber-reinforced polymer composite laminate fatigue

Anastasios Vassilopoulos

Investigations of the fatigue performance of composite materials have accompanied their introduction in several engineering domains since the 1950s. An abundance of publications have emerged dealing with the experimental investigation of the fatigue perfor ...

ELSEVIER SCI LTD2020

Experimental evaluation and modeling of fatigue of a 316L austenitic stainless steel in high-temperature water and air environments

Wen Chen, Wen Chen

Austenitic stainless steels is used in many components of nuclear power plants, particularly in the pipes of cooling systems. Owing to power transients and to start-ups and shutdowns, these components are subjected to thermo-mechanical loadings (low-cycle ...

EPFL2020

Probing Context-Dependent Modulations of Ipsilateral Premotor-Motor Connectivity in Relapsing-Remitting Multiple Sclerosis

Estelle Emeline Raffin

Objective: We employed dual-site TMS to test whether ipsilateral functional premotor-motor connectivity is altered in relapsing-remitting Multiple Sclerosis (RR-MS) and is related to central fatigue. ...

FRONTIERS MEDIA SA2020

Surgery-free injectable macroscale biomaterials for local cancer immunotherapy

Li Tang, Kewen Lei

Immunotherapy can harness the power of host's immune system to fight cancer. In the last few decades, tremendous progress has been made in this field, with remarkable clinical successes achieved consisting of a durable response in a fraction of patients. H ...

2019

Creep effects on tension-tension fatigue behavior of angle-ply GFRP composite laminates

Thomas Keller, Anastasios Vassilopoulos, Abdolvahid Movahedirad

Angle-ply (±45)2S glass/epoxy composite specimens have been subjected to pure creep and tension-tension constant amplitude fatigue loading interrupted at max by creep intervals lasting for 2 or 48 hours in order to examine the effects of creep loading on ...

2019

Stress ratio effect on tension-tension fatigue behavior of angle-ply GFRP laminates

Thomas Keller, Anastasios Vassilopoulos

The effect of the stress ratio (R = sigma(min)/sigma(max)) on the fatigue behavior of (+/- 45)(2s) angle-ply glass/epoxy composite laminates was investigated by comparing their mechanical, thermal, and optical properties under the stress ratio of 0.5 with ...

2019

Electromyographic indices of muscle fatigue of a severely paralyzed chronic stroke patient undergoing upper limb motor rehabilitation

Aurélien Patrick Maryse Maillot

Modern approaches to motor rehabilitation of severe upper limb paralysis in chronic stroke decode movements from electromyography for controlling rehabilitation orthoses. Muscle fatigue is a phenomenon that influences these neurophysiological signals and m ...

IEEE2019