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Concept

Myelin basic protein

Publications associées (14)

Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes

Tobias Kober, Tom Hilbert, Gian Franco Piredda

BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...

Amer Soc Neuroradiology2024

Signatures of life course socioeconomic conditions in brain anatomy

Maria del Carmen Sandi Perez

Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early-life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the bra ...

Wiley2022

Measuring compartmental T-2-orientational dependence in human brain white matter using a tiltable RF coil and diffusion-T-2 correlation MRI

Muhamed Barakovic

The anisotropy of brain white matter microstructure manifests itself in orientational-dependence of various MRI contrasts, and can result in significant quantification biases if ignored. Understanding the origins of this orientation-dependence could enhanc ...

2021

Model-informed machine learning for multi-component T2 relaxometry

Jean-Philippe Thiran, Tobias Kober, Meritxell Bach Cuadra, Tom Hilbert, Erick Jorge Canales Rodriguez, Cristina Granziera, Muhamed Barakovic, Marco Pizzolato, Elda Fischi Gomez, Thomas Yu, Gian Franco Piredda

Recovering the distribution from multi-echo magnetic resonance (MR) signals is challenging but has high potential as it provides biomarkers characterizing the tissue micro-structure, such as the myelin water fraction (MWF). In this work, we propose to comb ...

2020

Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice

Henning Paul-Julius Stahlberg

Myelin protein P2 is a peripheral membrane protein of the fatty acid–binding protein family that functions in the formation and maintenance of the peripheral nerve myelin sheath. Several P2 gene mutations cause human Charcot–Marie–Tooth neuropathy, but the ...

2020

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Maurizio Molinari

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B ...

2019

Mild Neonatal Brain Hypoxia-Ischemia in Very Immature Rats Causes Long-Term Behavioral and Cerebellar Abnormalities at Adulthood

Hongxia Lei, Yohan Van de Looij

Systemic hypoxia-ischemia (HI) often occurs during preterm birth in human. HI induces injuries to hinder brain cells mainly in the ipsilateral forebrain structures. Such HI injuries may cause lifelong disturbances in the distant regions, such as the contra ...

2019

ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury

Nicholas David James

We recently discovered a novel role for neuregulin-1 (Nrg1) signaling in mediating spontaneous regenerative processes and functional repair after spinal cord injury (SCI). We revealed that Nrg1 is the molecular signal responsible for spontaneous functional ...

2019

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease

Johan Auwerx, Laia Morato Fornaguera

Pelizaeus-Merzbacher disease (PMD) is a fatal hypomyelinating disorder characterized by early impairment of motor development, nystagmus, choreoathetotic movements, ataxia and progressive spasticity. PMD is caused by variations in the proteolipid protein g ...

2018

Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury

Grégoire Courtine

Tissue loss significantly reduces the potential for functional recovery after spinal cord injury. We previously showed that implantation of porous scaffolds composed of a biodegradable and biocompatible block copolymer of Poly-lactic-co-glycolic acid and P ...

2017

Quantitative Susceptibility Mapping in the Human Brain

Diana Khabipova

Magnetic resonance imaging (MRI) offers a good tissue contrast and the ability to visualize many disease related morphologies. The work presented in this thesis investigates the study of underlying structure of the brain using quantitative methods with a s ...

EPFL2016

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

Jean-Philippe Thiran, Rolf Gruetter, Patric Hagmann, Lijing Xin, Alessandra Griffa, Philipp Baumann

Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the ...

Nature Publishing Group2015

Synchrotron X Ray Induced Axonal Transections in the Brain of Rats Assessed by High-Field Diffusion Tensor Imaging Tractography

Yohan Van de Looij

Since approximately two thirds of epileptic patients are non-eligible for surgery, local axonal fiber transections might be of particular interest for them. Micrometer to millimeter wide synchrotron-generated X-ray beamlets produced by spatial fractionatio ...

Public Library Science2014

In vivo assessment of myelination by phase imaging at high magnetic field

Rolf Gruetter, José Pedro Rebelo Ferreira Marques, Rajika Maddage

The present study evaluated the potential of using the phase of T-2* weighted MR images to characterize myelination during brain development and pathology in rodents at 9.4 T. Phase contrast correlated with myelin content assessed by histology and suggests ...

Elsevier2012