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Concept

Nonunion

Publications associées (13)

Effect of minor amounts of beta-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of beta-tricalcium phosphate cylinders

Paul Bowen, Gabrielle Anne Laguisma Sblendorio

beta-Tricalcium Phosphate (beta-TCP), one of the most used bone graft substitutes, may contain up to 5 wt% foreign phase according to standards. Typical foreign phases include beta-calcium pyrophosphate (beta-CPP) and hydroxyapatite (HA). Currently, the ef ...

KEAI PUBLISHING LTD2022

Time-lapse reconstruction of the fracture front from diffracted waves arrivals in laboratory hydraulic fracture experiments

Brice Tanguy Alphonse Lecampion, Dong Liu, Thomas Emmanuel Blum

4-D acoustic imaging via an array of 32 sources/32 receivers is used to monitor hydraulic fracture (HF) propagating in a 250 mm cubic specimen under a true-triaxial state of stress. We present a method based on the arrivals of diffracted waves to reconstru ...

2020

Knitted Silk-Collagen Scaffold Incorporated with Ligament Stem/Progenitor Cells Sheet for Anterior Cruciate Ligament Reconstruction and Osteoarthritis Prevention

Dominique Pioletti, Ting Zhu

Current surgical management of anterior cruciate ligament (ACL) rupture still remains an intractable challenge in ACL regeneration due to the weak self-healing capability of ACL. Inadequate cell numbers and vascularization within the articular cavity contr ...

2019

Ectopic tissue engineered ligament with silk collagen scaffold for ACL regeneration: A preliminary study

Dominique Pioletti

Anterior cruciate ligament (ACL) reconstruction remains a formidable clinical challenge because of the lack of vascularization and adequate cell numbers in the joint cavity. In this study, we developed a novel strategy to mimic the early stage of repair in ...

Elsevier2017

Active Agent-Particle Combination Supporting Bone Regeneration

Dominique Pioletti, Ulrike Kettenberger

The invention provides for a bioactive composition comprising solid particles, such as e.g. calcium phosphate particles, loaded with an active agent, preferably an osteoconductive/osteoinductive agent or an anti-resorptive agent like a bisphosphonate. The ...

2017

Time course of bone screw fixation following a local delivery of zoledronate in a rat femoral model – a micro-finite element analysis

Dominique Pioletti, Alexandre Terrier, Ulrike Kettenberger, Adeliya Latypova

A good fixation of osteosynthesis implants is crucial for a successful bone healing but often difficult to achieve in osteoporotic patients. One possible solution to this issue is the local delivery of bisphosphonates in direct proximity to the implants, A ...

Elsevier2015

Injectable calcium phosphate cement for augmentation around cancellous bone screws. In vivo biomechanical studies

Dominique Pioletti, Vincent Stadelmann

In lower cancellous apparent bone density, it can be difficult to achieve adequate screw fixation and hence stable fracture fixation. Different strategies have been proposed, one of them is through augmentation using calcium phosphate cement in the region ...

Elsevier2012

Bone regeneration and stem cells

Dominique Pioletti

This invited review covers research areas of central importance for orthopaedic and maxillofacial bone tissue repair, including normal fracture healing and healing problems, biomaterial scaffolds for tissue engineering, mesenchymal and foetal stem cells, e ...

2011

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Jeffrey Alan Hubbell

Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...

2011

Augmentation of bone defect healing using a new biocomposite scaffold: an in vivo study in sheep

Dominique Pioletti, Pierre-Etienne Bourban, Laurence Marcelle Monique Rivier

Previous studies support resorbable biocomposites made of poly L-lactic acid (PLA) and β-tricalcium phosphate (TCP) produced by supercritical gas foaming as a suitable scaffold for tissue engineering. The present study was undertaken to demonstrate the bio ...

Elsevier2010

Fetal bone cells for tissue engineering

In this thesis, the potential use of fetal bone cells for tissue engineering was evaluated. At first, fetal bone cells were characterized in vitro regarding their proliferation rate, the induction of their osteoblastic phenotype, and their antigenicity. Th ...

EPFL2007

A composite biofoam, from research to in vivo validation

Jan-Anders Edvin Maansson, Dominique Pioletti, Pierre-Etienne Bourban

Bone tissue engineering aims at developing scaffolds, or porous structures, as supports for cell migration, proliferation and differentiation, in order to favor bone healing. L-poly lactic acid (PLA) foams, which were reinforced or not with β-tricalcium ph ...

2007

Theroretical and experimental multi-scale study of an artificial bone construct : from tibial osteotomy to cell/fluid interaction

Luc Blecha

Synthetic bone substitutes are potentially the future gold standard in orthopaedic and traumatologic surgery. The availability of these bone substitutes with different biomechanical properties may well replace autografts in the future as they overcome comp ...

EPFL2007