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Concept

Onchocercose

Publications associées (5)

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Melody Swartz, Alexandre de Titta, Esra Güç, David Scott Wilson, Marcela Rincón-Restrepo, Sachiko Hirosue

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

Nature Research2020

Clinical relevance of low-densityPlasmodium falciparumparasitemia in untreated febrile children: A cohort study

Mary-Anne Hartley

Background Low-density (LD)Plasmodiuminfections are missed by standard malaria rapid diagnostic tests (standard mRDT) when the blood antigen concentration is below the detection threshold. The clinical impact of these LD infections is unknown. This study i ...

2020

The microbiota provides colonisation resistance against intestinal helminths by regulating intestinal physiology

Luc Xavier Marie Lebon

Intestinal helminth infections are a global health problem affecting particularly people living in poor countries. Heavy worm burdens can lead to nutritional and cognitive deficiencies. Type-two immunity plays a crucial role in promoting tissue repair and ...

EPFL2017

In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis

Stewart Cole

Background Mycetoma is a neglected, chronic, and deforming infectious disease caused by fungi and actinomycetes. In Mexico, N. brasiliensis is the predominant etiologic agent. Therapeutic alternatives are necessary because the current drug regimens have se ...

Public Library of Science2015

Advances in helminth immunology: optimism for future vaccine design?

Nicola Harris

Intestinal helminths infect approximately 2 billion people worldwide. Worm burdens correlate with disease morbidity and children generally harbor the largest numbers. The majority of intestinal helminths do not replicate within their host, and worm burdens ...

2011