Concept

Addiction

Publications associées (29)

GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats

Maria del Carmen Sandi Perez, Ioannis Zalachoras

Social dominance can be attained through social competitions. Recent work in both humans and rodents has identified trait anxiety as a crucial predictor of social competitiveness. In addition, the anxiolytic GABAA positive modulator, diazepam, injected eit ...

2018

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Meltem Weger

Social rank is frequently established through aggressive encounters between new conspecifics. Despite increasing evidence suggesting that social rank is critical for the well-being of both humans and animals, knowledge about the factors influencing social ...

2018

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Jocelin Grosse, Olivia Zanoletti, Fiona Hollis, Ioannis Zalachoras, Laura Lozano Montes, Marie-Isabelle Guillot de Suduiraut

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

One-shot learning and eligibility traces in sequential decision making

Marco Philipp Lehmann

When humans or animals perform an action that led to a desired outcome, they show a tendency to repeat it. The mechanisms underlying learning from past experience and adapting future behavior are still not fully understood. In this thesis, I study how huma ...

EPFL2018

Spectral MAB for Unknown Graph Processes

Pascal Frossard, Laura Toni

In this work, we study graph-based multi-arms bandit (MAB) problems aimed at optimizing actions on irregular and high-dimensional graphs. More formally, we consider a decision-maker that takes sequential actions over time and observes the experienced rewar ...

IEEE Computer Society2018

A one-step mechanism for new twinning modes in magnesium and titanium alloys modelled by the obliquity correction of a (58 degrees, a+2b) prototype stretch twin

Cyril Cayron

The {11-22} and {11-26} twinning modes were recently discovered by Ostapovets et al. [Philos. Mag. (2017), 97, 1088-1101] and interpreted as {10-12}-{10-12} double twins formed by the simultaneous action of two twinning shears. Another interpretation is pr ...

Int Union Crystallography2018

Pansynaptic Enlargement at Adult Cortical Connections Strengthened by Experience

Graham Knott

Behavioral experience alters the strength of neuronal connections in adult neocortex. These changes in synaptic strength are thought to be central to experience-dependent plasticity, learning, and memory. However, it is not known how changes in synaptic tr ...

Oxford University Press2014

A preclinical model for identifying rats at risk of alcohol use disorder

Pierre Magistretti

Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains o ...

Springer Nature2017

Lactate release from astrocytes to neurons contributes to cocaine memory formation

Pierre Magistretti

The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons active ...

Wiley-Blackwell2016