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Concept

Anhédonie

Publications associées (18)

Information Processing Biases: The Effects of Negative Emotional Symptoms on Sampling Pleasant and Unpleasant Information

Steffen Alexander Herff

Although theories of emotion associate negative emotional symptoms with cognitive biases in information processing, they rarely specify the details. Here, we characterize cognitive biases in information processing of pleasant and unpleasant information, an ...

AMER PSYCHOLOGICAL ASSOC2022

Sex Differences in Comorbidity Combinations in the Swedish Population

Patrick Karl Alois Neff

High comorbidity rates, especially mental-physical comorbidity, constitute an increasing health care burden, with women and men being differentially affected. To gain an overview of comorbidity rates stratified by sex across a range of different conditions ...

MDPI2022

The diagnostic potential of multimodal neuroimaging measures in Parkinson's disease and atypical parkinsonism

Chang-Hyun Park

Introduction For the diagnosis of Parkinson's disease (PD) and atypical parkinsonism (AP) using neuroimaging, structural measures have been largely employed since structural abnormalities are most noticeable in the diseases. Functional abnormalities have b ...

2020

Electrophysiological correlates of visual backward masking in the schizophrenia continuum

Ophélie Gladys Favrod

In visual backward masking (VBM), a target is followed by a mask. Over the past decade, a VBM task, called the Shine-Through paradigm (ST), has been shown to be a very sensitive endophenotype of schizophrenia. In the present thesis, the electrophysiologica ...

EPFL2019

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Jocelin Grosse, Olivia Zanoletti, Fiona Hollis, Ioannis Zalachoras, Laura Lozano Montes, Marie-Isabelle Guillot de Suduiraut

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

Resting-State Networks of Adolescents Experiencing Depersonalization-Like Illusions: Cross-sectional and Longitudinal Findings

Dimitri Nestor Alice Van De Ville, François Lazeyras

The mirror-gazing task (MGT) experimentally induces illusions, ranging from simple color changes in the specular image of oneself, to depersonalization-like anomalous self-experiences (ASE) as in experiencing one's specular image as someone else. The objec ...

OXFORD UNIV PRESS2018

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype

Michael Herzog, Jacques Fellay, Maya Roinishvili, Flavia Aurelia Shoko Hodel

Schizophrenia is a chronic disorder determined by a complex mix of genetic and environmental factors. To better understand the contributions of human genetic variation to schizophrenia, we performed a genome-wide association study of a validated endophenot ...

2018

The complexity of schizophrenia: a battery of tests

Michael Herzog

Schizophrenia research has focused on single mechanisms mainly. Classically, a paradigm is chosen, such as a cognitive or perceptual test. The outcome is usually that schizophrenia patients perform worse than controls. Substantial research is then spent to ...

2016

Neuroligin-2 expression in the prefrontal cortex is involved in attention deficits induced by peripubertal stress

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Stamatina Tzanoulinou, Orbicia Riccio Wicht

Emerging evidence indicates that attention deficits, which are frequently observed as core symptoms of neuropsychiatric disorders, may be elicited by early life stress. However, the mechanisms mediating these stress effects remain unknown. The prefrontal c ...

2016

Does chronic nicotine consumption influence visual backward masking in schizophrenia and schizotypy?

Michael Herzog, Maya Roinishvili, Christine Mohr, Albulena Jashari-Shaqiri

Nicotine consumption is higher for people within the schizophrenia spectrum compared to controls. This observation supports the self-medication hypothesis, that nicotine relives symptoms in, for example, schizophrenia patients. We tested whether performanc ...

2015

Social deficits induced by peripubertal stress in rats are reversed by resveratrol

Maria del Carmen Sandi Perez, Olivia Zanoletti, Guillaume Poirier

Adolescence is increasingly recognized as a critical period for the development of the social system, through the maturation of social competences and of their underlying neural circuitries. The present study sought to test the utility of resveratrol, a di ...

2014

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Pierre Magistretti, Maria del Carmen Sandi Perez, Didier Trono, Maria Isabel Cordero Campana, Guillaume Poirier, Anna Claire Groner

Although adverse early life experiences have been found to increase lifetime risk to develop violent behaviors, the neurobiological mechanisms underlying these long-term effects remain unclear. We present a novel animal model for pathological aggression in ...

Nature Publishing Group2013

Cognitive disorganisation in schizotypy is associated with deterioration in visual backward masking

Michael Herzog, Christine Mohr, Daniela Herzig

To understand the causes of schizophrenia, a search for stable markers (endophenotypes) is ongoing. In previous years, we have shown that the shine-through visual backward masking paradigm meets the most important characteristics of an endophenotype. Here, ...

Elsevier2012

Sex moderates the relationship between cognitive disorganisation and visual backward masking: potential implications for an endophenotype of schizophrenia

Michael Herzog, Christine Mohr

Schizophrenia is a severe mental disorder that impairs individuals’ life, often chronically and from early adulthood on. There is a search for endophenotypes, i.e. stable markers of the genetic underpinnings of the disease. Visual backward masking (VBM) is ...

2012

Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats

Maria del Carmen Sandi Perez

Affective symptoms such as anxiety and depression are frequently observed in patients with epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however, remain unclear. Diverse models are traditionally used in epilepsy research, inc ...

Public Library of Science2012

Machine Vision-Based Analysis of Gaze and Visual Context : an Application to Visual Behavior of Children with Autism Spectrum Disorders

Basilio Noris

Visual behavior, and specifically gaze directed at objects and people, is a fundamental cue for understanding how children with Autism Spectrum Disorder (ASD) experience and respond to social interaction. Indeed atypical behaviors such as averting the gaze ...

EPFL2011

First-order relatives of schizophrenic patients are not impaired in the Continuous Performance Test

Michael Herzog, Maya Roinishvili

Sustained attention deficits measured by the Continuous Performance Test (CPT) have been reportedly proposed as an endophenotype of schizophrenia. One requirement for an endophenotype is that unaffected first-order relatives must show deteriorated performa ...

Taylor & Francis2010

Differential impact of polysialyltransferase ST8SiaII and ST8iaIV knockout on social interaction and aggression

Maria del Carmen Sandi Perez

Previous studies using neuronal cell adhesion molecule (NCAM) -/- knockout (KO) mice provided evidence for a role of NCAMs in social behaviors. However, polysialic acid (PSA), the most important post-translational modification of NCAM, was also absent in t ...

Wiley-Blackwell2010