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Concept

Hippocampal sclerosis

Publications associées (21)

Community-based reconstruction and simulation of a full-scale model of region CA1 of rat hippocampus

Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Werner Alfons Hilda Van Geit, Lida Kanari, Srikanth Ramaswamy, James Gonzalo King, Alexis Arnaudon, Ying Shi, András Ecker, Jean-Denis Georges Emile Courcol, Armando Romani, Pramod Shivaji Kumbhar, Judit Planas Carbonell, Michael Emiel Gevaert, Nadir Roman Guerrero, Liesbeth Maria L Vanherpe, Huanxiang Lu, Mohameth François Sy, Cristina Colangelo, Juan Bautista Hernando Vieites, Cyrille Pierre Henri Favreau, Genrich Ivaska, Anna-Kristin Kaufmann, Joni Henrikki Herttuainen, Elvis Boci, Vishal Sood, Thomas Brice Delemontex, Fabien Petitjean, Julian Martin Budd, Mustafa Kerem Kurban, Alberto Antonietti, Davide Bella, Pranav Rai

The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, i ...

2024

Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs

Ying Shi, Armando Romani, Maurizio Ferdinando Pezzoli

The fundamental role of any neuron within a network is to transform complex spatiotemporal synaptic input patterns into individual output spikes. These spikes, in turn, act as inputs for other neurons in the network. Neurons must execute this function acro ...

2023

Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing study

Dimitri Nestor Alice Van De Ville, Patric Hagmann, Maria Giulia Preti

Objective: Structure-function coupling remains largely unknown in brain disorders. We studied this coupling during interictal epileptic discharges (IEDs), using graph signal processing in temporal lobe epilepsy (TLE). ...

ELSEVIER IRELAND LTD2023

High levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience

Elenor Morgenroth

Childhood trauma (CT) has been linked to increased risk for psychosis. Moreover, CT has been linked to psychosis phenotypes such as impaired cognitive and sensory functions involved in the detection of novel sensory stimuli. Our objective was to investigat ...

SPRINGER HEIDELBERG2023

EEG Spatiotemporal Patterns Underlying Self-other Voice Discrimination

Olaf Blanke, Pavo Orepic, Sixto Luis Alcoba Banqueri

There is growing evidence showing that the representation of the human “self” recruits special systems across different functions and modalities. Compared to self-face and self-body representations, few studies have investigated neural underpinnings specif ...

2021

When shared concept cells support associations: Theory of overlapping memory engrams

Wulfram Gerstner, Tilo Schwalger, Emanuela De Falco, Chiara Gastaldi

Assemblies of neurons, called concepts cells, encode acquired concepts in human Medial Temporal Lobe. Those concept cells that are shared between two assemblies have been hypothesized to encode associations between concepts. Here we test this hypothesis in ...

2021

OpenPifPaf: Composite Fields for Semantic Keypoint Detection and Spatio-Temporal Association

Alexandre Massoud Alahi, Sven Kreiss, Lorenzo Bertoni

Many image-based perception tasks can be formulated as detecting, associating and tracking semantic keypoints, e.g., human body pose estimation and tracking. In this work, we present a general framework that jointly detects and forms spatio-temporal keypoi ...

IEEE Institute of Electrical and Electronics Engineers2022

Remodeling of brain morphology in temporal lobe epilepsy

Lester Melie Garcia

Background Mesial temporal lobe epilepsy (TLE) is one of the most widespread neurological network disorders. Computational anatomy MRI studies demonstrate a robust pattern of cortical volume loss. Most statistical analyses provide information about localiz ...

2020

Hippocampal Contribution to Ordinal Psychological Time in the Human Brain

Baptiste Gauthier

The chronology of events in time-space is naturally available to the senses, and the spatial and temporal dimensions of events entangle in episodic memory when navigating the real world. The mapping of time-space during navigation in both animals and human ...

MIT PRESS2020

Depersonalization- and derealization-like phenomena of epileptic origin

Olaf Blanke, Lukas Heydrich, Nathaniel Evans

Objective Depersonalization refers to the sensation of being detached from one's body, often associated with feelings of loss of control over one's own body, actions, or thoughts. Derealization refers to the altered perception of one's surroundings that is ...

2019

A challenge of predicting seizure frequency in temporal lobe epilepsy using neuroanatomical features

Chang-Hyun Park

The pathological and clinical characteristics of temporal lobe epilepsy (TLE) tend to be affected by epileptic seizures, specifically represented by seizure lateralization and frequency. Although the lateralization of the epileptogenic zone can be clarifie ...

ELSEVIER IRELAND LTD2019

Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans

Silvestro Micera, Fiorenzo Artoni, Stanisa Raspopovic, Francesco Maria Petrini, Fabrizio Vecchio

Restoration of touch after hand amputation is a desirable feature of ideal prostheses. Here, we show that texture discrimination can be artificially provided in human subjects by implementing a neuromorphic real-time mechano-neuro-transduction (MNT), which ...

Elife Sciences Publications Ltd2016

Word pair classification during imagined speech using direct brain recordings

José del Rocio Millán Ruiz, Inaki Asier Iturrate Gil, Stéphanie Martin

People that cannot communicate due to neurological disorders would benefit from an internal speech decoder. Here, we showed the ability to classify individual words during imagined speech from electrocorticographic signals. In a word imagery task, we used ...

Nature Research2016

Lateralising value of experiential hallucinations in temporal lobe epilepsy

Olaf Blanke, Lukas Heydrich, Nathaniel Evans

Objectives Ever since John Hughlings Jackson first described the so-called 'dreamy state' during temporal lobe epilepsy, that is, the sense of an abnormal familiarity (deja vu) or vivid memory-like hallucinations from the past (experiential hallucinations) ...

Bmj Publishing Group2015

The mechanisms of spatial and temporal patterning of cell-edge dynamics

Alexander Verkhovskiy

Adherent cells migrate and change their shape by means of protrusion and retraction at their edges. When and where these activities occur defines the shape of the cell and the way it moves. Despite a great deal of knowledge about the structural organizatio ...

Elsevier2015

Structural Graph Analysis of Left and Right Temporal Lobe Epilepsy using Diffusion Spectrum Imaging

Jean-Philippe Thiran, Alessandro Daducci, François Lazeyras, Alia Lemkaddem

Patients with Temporal Lobe Epilepsy (TLE) suffer from widespread subtle white matter abnormalities and abnormal functional connectivity extending beyond the affected lobe, as revealed by volumetric and functional MRI studies. Diffusion Magnetic Resonance ...

2014

Implicit Affective Profiling of Subjects based on Physiological Data Coupling

Touradj Ebrahimi, Jean-Marc Vesin, Eleni Kroupi

Evidence from neuroscience and psychology supports the idea that synchronization among various sub-components of the organism is the key-point to emotional processes. This study investigates the way signals from the central nervous system interact with sig ...

2014

Whole-brain structural connectivity in temporal lobe epilepsy: a Diffusion Spectrum Imaging study

Jean-Philippe Thiran, Alessandro Daducci, Alessandra Griffa, Alia Lemkaddem, François Lazeyras

Introduction: Medial Temporal Lobe Epilepsy (mTLE) with hippocampal sclerosis is the most frequent cause of drug-resistant focal epilepsy in adults. These patients suffer from widespread subtle white matter abnormalities and abnormal functional connectivit ...

2012

Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats

Maria del Carmen Sandi Perez

Affective symptoms such as anxiety and depression are frequently observed in patients with epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however, remain unclear. Diverse models are traditionally used in epilepsy research, inc ...

Public Library of Science2012

In-vivo magnetic resonance imaging of the structural core of the Papez circuit in humans

Reto Meuli, Cristina Granziera, Nouchine Hadjikhani

Papez circuit is one of the major pathways of the limbic system, and it is involved in the control of memory and emotion. Structural and functional alterations have been reported in psychiatric, neurodegenerative, and epileptic diseases. Despite the clinic ...

2011