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Concept

Ordinateur à ADN

Publications associées (8)

Fixed DNA Molecule Arrays for High-Throughput Single DNA-Protein Interaction Studies

Vytautas Navikas

The DNA Curtains assay is a recently developed experimental platform for protein-DNA interaction studies at the single-molecule level that is based on anchoring and alignment of DNA fragments. The DNA Curtains so far have been made by using chromium barrie ...

AMER CHEMICAL SOC2019

An Interactive Gameplay to Crowdsource Multiple Sequence Alignment of Genome Sequences: Genenigma

Kalpani Anuradha Welivita

Comparative genomics is a field of research that compares genomes of different organisms to identify common patterns. It is a powerful method used to identify the genetic diseases that cause mutations. Multiple Sequence Alignment (MSA) is an intermediate s ...

ASSOC COMPUTING MACHINERY2019

Logic Synthesis for Established and Emerging Computing

Giovanni De Micheli, Mathias Soeken, Luca Gaetano Amarù, Eleonora Testa

Logic synthesis is an enabling technology to realize integrated computing systems, and it entails solving computationally intractable problems through a plurality of heuristic techniques. A recent push toward further formalization of synthesis problems has ...

2018

Synthesis of Responsive Two-Dimensional Polymers via Self-Assembled DNA Networks

Duncan Thomas Lindsay Alexander, Ulrich Aschauer

Despite a growing interest in two-dimensional polymers, their rational synthesis remains a challenge. The solution-phase synthesis of a two-dimensional polymer is reported. ADNA-based monomer self-assembles into a supra-molecular network, which is further ...

Wiley-VCH Verlag GmbH2017

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies

Kristina Pan Woodruff

With the advent of high-throughput and genome-wide screening initiatives, there is a need for improved methods for cell-based assays. Current approaches require expensive equipment, rely on large-scale culturing formats not suited for small or rare sample ...

EPFL2017

A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Sebastian Maerkl, Kristina Pan Woodruff

Mammalian synthetic biology could be augmented through the development of high-throughput microfluidic systems that integrate cellular transfection, culturing, and imaging. We created a microfluidic chip that cultures cells and implements 280 independent t ...

Nature Research2016

Integrated computational approaches for spectroscopic studies of molecular systems in the gas phase and in solution: pyrimidine as a test case

Fabio Trani

An integrated computational approach built on quantum mechanical (QM) methods, purposely tailored inter-and intra-molecular force fields and continuum solvent models combined with time-independent and timedependent schemes to account for nuclear motion eff ...

2012

Design and Implementation of Multi-camera Systems Distributed over a Spherical Geometry

Yusuf Leblebici, Alexandre Schmid, Hossein Afshari, Kerem Seyid

The current trend in constructing high-end computing systems consists of parallelizing large numbers of processors. A similar trend is observed in digital imaging where multiple camera inputs are utilized to obtain multiple images of a scene and thus enhan ...

2012