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Concept

Gliogenesis

Publications associées (25)

Designing materials to direct stem-cell fate

Matthias Lütolf

Proper tissue function and regeneration rely on robust spatial and temporal control of biophysical and biochemical microenvironmental cues through mechanisms that remain poorly understood. Biomaterials are rapidly being developed to display and deliver ste ...

2009

Glycogen metabolism as a marker of astrocyte differentiation

Pierre Magistretti, Igor Allaman

Glycogen is a hallmark of mature astrocytes, but its emergence during astrocytic differentiation is unclear. Differentiation of E14 mouse neurospheres into astrocytes was induced with fetal bovine serum (FBS), Leukemia Inhibitory Factor (LIF), or Ciliary N ...

2009

Recruiting new neurons from the subventricular zone to the rat postnatal cortex: an organotypic slice culture model

The neurogenic subventricular zone (SVZ) of the lateral ventricle is a potential source for neuronal replacement in the postnatal or adult neocortex after injury. Here we present a novel model system to directly explore the cellular mechanisms of this proc ...

2008

Multiple roles of Notch signaling in the regulation of epidermal development

Freddy Radtke

Recent studies have shown that Notch signaling plays an important role in epidermal development, but the underlying molecular mechanisms remain unclear. Here, by integrating loss- and gain-of-function studies of Notch receptors and Hes1, we describe molecu ...

Cell Press - Elsevier2008

Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex

Freddy Radtke

Neuronal migration is a fundamental component of brain development whose failure is associated with various neurological and psychiatric disorders. Reelin is essential for the stereotypical inside-out sequential lamination of the neocortex, but the molecul ...

2008