Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Concept

Trouble envahissant du développement

Publications associées (20)

Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism

Grégoire Courtine, Eduardo Martin Moraud, Tomislav Milekovic, Shiqi Sun

Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...

2018

Pretherapeutic resting-state fMRI profiles are associated with MR signature volumes after stereotactic radiosurgical thalamotomy for essential tremor

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Meritxell Bach Cuadra, Constantin Tuleasca, Thomas William Arthur Bolton, Adrien Jean Régis Maurice Hilaire

OBJECTIVE Essential tremor (ET) is the most common movement disorder. Drug-resistant ET can benefit from standard stereotactic deep brain stimulation or radiofrequency thalamotomy or, alternatively, minimally invasive techniques, including stereotactic rad ...

AMER ASSOC NEUROLOGICAL SURGEONS2018

A GIS based approach for analysing geological and operation conditions influence on road tunnels degradation

Vincent Labiouse, Federica Sandrone

Adopting effective maintenance strategies for transportation infrastructures requires good prediction of their long-term behaviour. For planning interventions without affecting the entire network’s capacity, tunnels in particular require a good overview of ...

Elsevier2017

Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development

Cathrin Brisken, Alessandra Piersigilli, Marian Caikovski, Dalya Ataca, Yakir Guri

The ADAMTS family comprises 19 secreted metalloproteinases that cleave extracellular matrix components and have diverse functions in numerous disease and physiological contexts. A number of them remain 'orphan' proteases, among them ADAMTS18, which has bee ...

Company Of Biologists Ltd2016

The effects of stress during early postnatal periods on behavior and hippocampal neuroplasticity markers in adult male mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Aurélie Lattion

Infancy is a critical period for brain development. Emerging evidence indicates that stress experienced during that period can have long-term programming effects on the brain and behavior. However, whether different time periods represent different vulnera ...

2015

Characterizing the connectome in schizophrenia with diffusion spectrum imaging

Jean-Philippe Thiran, Patric Hagmann, Alessandra Griffa

Schizophrenia is a complex psychiatric disorder characterized by disabling symptoms and cognitive deficit. Recent neuroimaging findings suggest that large parts of the brain are affected by the disease, and that the capacity of functional integration betwe ...

Wiley-Blackwell2015

Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis

Stewart Cole, Florence Pojer, Jérémie Piton, Aleksandre Japaridze

Mycobacterium tuberculosis secretes multiple virulence factors during infection via the general Sec and Tat pathways, and via specialized ESX secretion systems, also referred to as type VII secretion systems. The ESX-1 secretion system is an important viru ...

Elsevier2015

A Wearable Camera Detects Gaze Peculiarities during Social Interactions in Young Children with Pervasive Developmental Disorders

Aude Billard, Patrick Jermann, Basilio Noris, Silvia Magrelli

We report on the study of gazes, conducted on children with pervasive developmental disorders (PDD), by using a novel head-mounted eye-tracking device called the WearCam. Due to the portable nature of the WearCam, we are able to monitor naturalistic intera ...

Ieee-Inst Electrical Electronics Engineers Inc2014

General developmental health in the VPA-rat model of autism

Henry Markram, Kamila Markram, Georges Khazen, Mônica Regina Favre

Autism is a neurodevelopmental condition diagnosed by impaired social interaction, abnormal communication and, stereotyped behaviors. While post-mortem and imaging studies have provided good insights into the neurobiological symptomology of autism, animal ...

Frontiers Research Foundation2013

The missing social instinct : behavioral and functional brain imaging investigations in autism

Smooth social interactions in everyday life rely on spontaneous understanding of emotions and intentions of others, conveyed by subtle social cues, such as gaze and facial expressions. In individuals with autism, however, who represent close to 1% of the p ...

EPFL2012

Comparing the neural bases of self-referential processing in typically developing and 22q11.2 adolescents

Roy Salomon, Maude Schneider

The investigation of self-reflective processing during adolescence is relevant, as this period is characterized by deep reorganization of the self-concept. It may be the case that an atypical development of brain regions underlying self-reflective processi ...

Elsevier Sci Ltd2012

Machine Vision-Based Analysis of Gaze and Visual Context : an Application to Visual Behavior of Children with Autism Spectrum Disorders

Basilio Noris

Visual behavior, and specifically gaze directed at objects and people, is a fundamental cue for understanding how children with Autism Spectrum Disorder (ASD) experience and respond to social interaction. Indeed atypical behaviors such as averting the gaze ...

EPFL2011

Effects of hardware heterogeneity on the performance of SVM Alzheimer's disease classifier

Gunnar Krüger, Bénédicte Marie Maréchal

Fully automated machine learning methods based on structural magnetic resonance imaging data can assist radiologists in the diagnosis of Alzheimer's disease (AD). These algorithms require large data sets to learn the separation of subjects with and without ...

Elsevier2011

Illusory own body perceptions: case reports and relevance for bodily self-consciousness

Olaf Blanke, Lukas Heydrich, Sebastian Dieguez Falcon

Neurological disorders of body representation have for a long time suggested the importance of multisensory processing of bodily signals for self-consciousness. One such group of disorders--illusory own body perceptions affecting the entire body--has been ...

Elsevier2010

Analysis of the evolution of road tunnels equilibrium conditions with a convergence–confinement approach

Vincent Labiouse, Federica Sandrone

Since both lining structure and rock mass exhibit delayed behaviour, tunnel equilibrium conditions evolve with time. After discussing existing work done on different aspects of long-term tunnel behaviour, the aim of this paper is to “understand” the influe ...

Springer Vienna2010

fMRI activation during a language task in adolescents with ASD

Nouchine Hadjikhani

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by language and communication impairments, social impairments, and repetitive behaviors or restricted interests. Previous Studies of semantic functions have found differences in ...

Cambridge University Press2008

Analysis of pathologies and long term behaviour of the Swiss national road tunnels

Federica Sandrone

This project, supported by the Swiss Federal Roads Authority (OFROU), focuses on the long term behaviour of road tunnels and on their main pathologies. As a tunnel is composed by lining structure and rock mass, it has been necessary to consider the effects ...

EPFL2008

Methods For Treating And/Or Preventing Pervasive Developmental Disorders In A Subject

Henry Markram, Tania Rinaldi, Karina Kulangara

The present invention concerns a method for treating and/or preventing a Pervasive Developmental Disorder in a subject in need thereof comprising the step of modulating the synaptic connectivity in the neocortex by administering a therapeutically effective ...

2007

WearCam: A head mounted wireless camera for monitoring gaze attention and for the diagnosis of developmental disorders in young children

Aude Billard, Basilio Noris

Autism covers a large spectrum of disorders that affect the individual’s way of interacting socially and is often revealed by the individual’s lack of interest in gazing at human faces. Currently Autism is diagnosed in children no younger than 2 years old. ...

2007

Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

Henry Markram, Tania Rinaldi, Karina Kulangara

Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but underlyin ...

National Academy of Sciences2007