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Concept

Cellule de Purkinje

Publications associées (29)

Multi-Modal Optical Imaging of the Cerebellum in Animals

Graham Knott

Thanks to their flexibility, optical techniques could be the key to explore anatomy, plasticity, and functionality of the cerebellum. As an example, an in vivo analysis of the dynamic remodeling of cerebellar axons by nonlinear microscopy can provide funda ...

Springer2016

A coupled 3D-1D numerical monodomain solver for cardiac electrical activation in the myocardium with detailed Purkinje network

Alfio Quarteroni, Christian Vergara, Toni Mikael Lassila

We present a model for the electrophysiology in the heart to handle the electrical propagation through the Purkinje system and in the myocardium, with two-way coupling at the Purkinje-muscle junctions. In both the subproblems the monodomain model is consid ...

Elsevier2016

When Neurons Fail - Technical Report

Rachid Guerraoui, El Mahdi El Mhamdi

Neural networks have been traditionally considered robust in the sense that their precision degrades gracefully with the failure of neurons and can be compensated by additional learning phases. Nevertheless, critical applications for which neural networks ...

EPFL2016

Duration of Purkinje cell complex spikes increases with their firing frequency

Michele Giugliano

Climbing fiber (CF) triggered complex spikes (CS) are massive depolarization bursts in the cerebellar Purkinje cell (PC), showing several high frequency spikelet components (+/- 600 Hz). Since its early observations, the CS is known to vary in shape. In th ...

Frontiers Research Foundation2015

On the Firing Rate Dependency of the Phase Response Curve of Rat Purkinje Neurons In Vitro

Michele Giugliano

Synchronous spiking during cerebellar tasks has been observed across Purkinje cells: however, little is known about the intrinsic cellular mechanisms responsible for its initiation, cessation and stability. The Phase Response Curve (PRC), a simple input-ou ...

Public Library Science2015

At the Edge of Chaos: How Cerebellar Granular Layer Network Dynamics Can Provide the Basis for Temporal Filters

Models of the cerebellar microcircuit often assume that input signals from the mossy-fibers are expanded and recoded to provide a foundation from which the Purkinje cells can synthesize output filters to implement specific input-signal transformations. Det ...

Public Library of Science2015

Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro

Human cell reprogramming technologies offer access to live human neurons from patients and provide a new alternative for modeling neurological disorders in vitro. Neural electrical activity is the essence of nervous system function in vivo. Therefore, we e ...

National Academy of Sciences2015

Patient-specific generation of the Purkinje network driven by clinical measurements of a normal propagation

Alfio Quarteroni, Fabio Nobile, Christian Vergara, Elena Faggiano

The propagation of the electrical signal in the Purkinje network is the starting point for the activation of the ventricular muscular cells leading to the contraction of the ventricle. In the computational models, describing the electrical activity of the ...

Springer Verlag2014

The Relationship between PSD-95 Clustering and Spine Stability In Vivo

Graham Knott, Bohumil Maco

The appearance and disappearance of dendritic spines, accompanied by synapse formation and elimination may underlie the experience-dependent reorganization of cortical circuits. The exact temporal relationship between spine and synapse formation in vivo re ...

Soc Neuroscience2014