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Concept

Règle de Markovnikov

Publications associées (11)

Modular Synthesis of Benzocyclobutenes via Pd(II)-Catalyzed Oxidative [2+2] Annulation of Arylboronic Acids with Alkenes

Jieping Zhu, Anne-Clémence Corminboeuf, Qian Wang, Simone Gallarati, Takuji Fujii

Benzocyclobutenes (BCBs) are highly valuable compounds in organic synthesis, medicinal chemistry, and materials science. However, catalytic modular synthesis of functionalized BCBs from easily accessible starting materials remains limited. We report herein ...

2022

Streamlined Alkylation via Nickel-Hydride-Catalyzed Hydrocarbonation of Alkenes

Xile Hu, Srikrishna Bera, Zhikun Zhang, Chao Fan

Compounds rich in sp(3)-hybridized carbons are desirable in drug discovery. Nickel-catalyzed hydrocarbonation of alkenes is a potentially efficient method to synthesize these compounds. By using abundant, readily available, and stable alkenes as pro-nucleo ...

2022

Development of remote C-H bond functionalization of redox-active alcohol derivatives and oxidative transformations under photoredox catalysis

Alexandre Julien Florent Leclair

The development of radical-based remote C(sp3)-H functionalizations of redox-active alcohol derivatives, oxidative cycloaddition and rearrangement transformations under visible light photocatalysis constitute the basis of this thesis. The first chapter des ...

EPFL2021

Photocatalytic Umpolung of N- and O-substituted alkenes for the synthesis of 1,2-amino alcohols and diols

Jérôme Waser, Stefano Nicolai, Stephanie Grace Elizabeth Amos

We report an organophotocatalytic 1,2-oxyalkynylation of ene-carbamates and enol ethers using Ethynyl BenziodoXolones (EBXs). 1-Alkynyl-1,2-amino alcohols and diols were obtained in up to 89% yield. Photocatalytic formation of radical cations led to Umpolu ...

2020

Modeling, predicting and mining metabolism at atom-level resolution

Jasmin Maria Hafner

Living organisms can catalyze many thousands of biochemical reactions that they use to convert energy and matter, which provides them with the essentials for life. The sum of these chemical reactions happening in an organism is called metabo-lism. Understa ...

EPFL2020

Arylsilylation of Electron-Deficient Alkenes via Cooperative Photoredox and Nickel Catalysis

Xile Hu, Zhikun Zhang

Carbosilylation of alkenes can be an efficient approach to the synthesis of organosilicon compounds. However, few general methods of carbosilylation are known. Here, we introduce a strategy for arylsilylation of electron deficient terminal alkenes by combi ...

2020

Stereoselective synthesis of alkenes via base-metal-catalyzed addition reactions to alkynes and activation of hydrogen peroxide and carbon dioxide by iron complexes

Fedor Zhurkin

Alkene functionality can be found in the majority of natural products, drugs, catalysts and organic materials. Therefore, methods of C-C double bond formation constitute a cornerstone of organic synthesis. Selective formation of either (Z)- or (E)-isomer i ...

EPFL2017

Spherical superstructures of oxide nanoparticles for catalytic reactions in microchemical reactors

Martinus Adela Maria Gijs, Virendra Kumar Parashar, Josias Basil Wacker

We report the fabrication of spherical superstructures composed of SiO2 and TiO2 nanoparticles and their applications in catalyzing organic reactions. Assembling of the nanoparticles into superstructures is done by heating a water-in-oil micro-emulsion, wh ...

Elsevier Science Bv2015

Electron Capture Dissociation Product Ion Abundances at the X Amino Acid in RAAAA-X-AAAAK Peptides Correlate with Amino Acid Polarity and Radical Stability

Yury Tsybin, Aleksey Vorobyev, Hisham Ben Hamidane

We present mechanistic studies aimed at improving the understanding of the product ion formation rules in electron capture dissociation (ECD) of peptides and proteins in Fourier transform ion cyclotron resonance mass spectrometry. In particular, we attempt ...

Springer-Verlag2009

A bimetallic ruthenium ethylene complex as a catalyst precursor for the Kharasch reaction

Kay Severin, Euro Solari, Laurent Quebatte

A bimetallic complex, in which a RuCl2 (eta(2)C(2)H(4))(PCy3) fragment is connected via three chloro, bridges to a (eta(6)-p-cymene)RuCl2 fragment, has been synthesized and characterized by single-crystal X-ray crystallography. This complex was used to cat ...

2005

Perfluorinated alkoxyaluminate salts of cationic Bronsted acids: Synthesis, structure, and characterization of [H(OEt2)2][Al{OC(CF3)3}4] and [H(THF)2][Al{OC(CF3)3}4]

Andreas Reisinger

The strong cationic Bronsted acids [H(OEt2)2][Al{OC(CF3)3}4] (1) and [H(THF)2][Al{OC(CF3)3}4] (2) were prepd. in up to 95% yield by reacting stoichiometric amts. of di-Et ether/THF solns. of Li[Al{OC(CF3)3}4] and HX (X = Cl, Br), removing the solvent, and ...

2005