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Concept

Formulation

Publications associées (24)

Hierarchy of the Components in Spray-Dried, Protein-Excipient Particles Using DNP-Enhanced NMR Spectroscopy

David Lyndon Emsley, Pierrick Berruyer, Andrea Bertarello, Baptiste Busi

Protein-based drugs are becoming increasingly important, but there are challenges associated with their formulation (for example, formulating stable inhalable aerosols while maintaining the proper long-term stability of the protein). Determining the morpho ...

Amer Chemical Soc2023

Development of stimuli-responsive chemistry for tumor-targeted immunotherapy

Céline Jasmin Prange

Cancer immunotherapy is the science of boosting the immune response of patients to fight cancer. Recent advances have brought up treatments with huge success in the clinic. Patients with ad-vanced-stage cancers were long-term cured through checkpoint inhib ...

EPFL2023

Selectively permeable microcapsules

Chuen-Ru Li

Microcapsules are appealing containers for delivering active ingredients, such as drugs and cosmetics, or conducting chemical and biological reactions on a small scale. To control the timing and location of release of these encapsulants, the shells of micr ...

EPFL2023

Thermal Sintering and Phosphorus Poisoning of a Layered Diesel Oxidation Catalyst

Oliver Kröcher, Davide Ferri

The tightening emission regulations have led to the development of commercial DOCs with zoned or layered formulations allowing to cover a wide range of functionalities (i.e. CO, HC and NO oxidation as well as HC or NOx trap). Aging phenomena in such comple ...

SPRINGER/PLENUM PUBLISHERS2023

Highly Sensitive Detection of the Antidepressant Fluoxetine With an Extended Gate Field Effect Transistor

Mihai Adrian Ionescu, Shokoofeh Sheibani

Fluoxetine (FL) is one of the selective serotonin reuptake inhibitors, which is used as an anti-depressant, as well as anti-panic drug. In this work, a sensor for label-free recognition of trace amounts of FL is introduced, which is based on an extended ga ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix

Maria-Alexandra Paun

A suite of four drug deliverance formulations grounded on 5-fluorouracil enclosed in a chitosan-founded intercellular substance was produced by 3,7-dimethyl-2,6-octadienal with in situ hydrogelation. The formulations have been examined from a morphological ...

MDPI2022

Wigner Formulation of Thermal Transport in Solids

Nicola Marzari, Michele Simoncelli

Two different heat-transport mechanisms are discussed in solids. In crystals, heat carriers propagate and scatter particlelike as described by Peierls's formulation of the Boltzmann transport equation for phonon wave packets. In glasses, instead, carriers ...

American Physical Society2022

Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix

Maria-Alexandra Paun

Four medicament delivery formulations based on 5-fluorouracil in a chitosan substantial matrix were realized in situ via 3,7-dimethyl-2,6-octadienal element hydrogelation. Representative samples of the final realized compounds were investigated from an ana ...

MDPI2022

Hemodynamics of the heart's left atrium based on a Variational Multiscale-LES numerical method

Alfio Quarteroni, Filippo Menghini

In this paper, we investigate the haemodynamics of a left atrium (LA) by proposing a computational model suitable to provide physically meaningful fluid dynamics indications and detailed blood flow characterization. In particular, we consider the incompres ...

ELSEVIER2021

OPF-driven Under Frequency Load Shedding in Low-Inertia Power Grids Hosting Large-scale Battery Energy Storage Systems

Mario Paolone, Asja Derviskadic, Yihui Zuo

The paper describes the formulation and application of an Optimal Power Flow (OPF)-driven Under Frequency Load Shedding (UFLS) scheme in low-inertia power grids hosting large-scale battery energy storage systems. Thanks to the accurate prediction of the sy ...

IEEE2021

Vessel scheduling with pilotage and tugging considerations

Michel Bierlaire

This paper considers vessel scheduling with pilotage and tugging constraints in berthing operations with channel restrictions at seaports. To our knowledge, pilotage and tugging requirements have not been simultaneously considered in the literature. This w ...

PERGAMON-ELSEVIER SCIENCE LTD2021

Worldwide performance evaluation of ground surface reflectance models

Christophe Ballif, Arttu Matias Tuomiranta

To improve the accuracy of bifacial gain estimation, recent radiative models of solar energy systems have abandoned the traditional assumption of isotropic ground-reflected radiance. However, surface reflectance itself is still commonly considered as a con ...

2021

Structure determination of an amorphous drug through large-scale NMR predictions

David Lyndon Emsley, Manuel Cordova, Albert Hofstetter, Pierrick Berruyer, Federico Maria Paruzzo, Bruno Simões de Almeida, Martins Balodis

Knowledge of the structure of amorphous solids can direct, for example, the optimization of pharmaceutical formulations, but atomic-level structure determination in amorphous molecular solids has so far not been possible. Solid-state nuclear magnetic reson ...

Nature Research2021

A Mixed-Integer Linear Programming Formulation for Optimizing Multi-Scale Material and Energy Integration

François Maréchal, Ivan Daniel Kantor, Hür Ebuzer Bütün, Jean-Loup Sylvain Robineau

This research presents a mathematical formulation for optimizing integration of complex industrial systems from the level of unit operations to processes, entire plants, and finally to considering industrial symbiosis opportunities between plants. The fram ...

2020

Released Diclofenac Sodium Salt From Chitosan Embedding In A Hydrogel Matrix. A Theoretical And Experimental Study

Maria-Alexandra Paun

Two formulations embedding diclofenac sodium salt into a chitosan hydrogel matrix with different crosslinking degree were prepared by in situ hydrogelation. The formulations were investigated by polarized light microscopy and scanning electron microscopy, ...

UNIV POLITEHNICA BUCHAREST, SCI BULL2020

Experimental And Theoretical Insight Into Formulations Based On Poly(Vinyl Alcohol Boric Acid) And Diclofenac Sodium Salt

Maria-Alexandra Paun

A series of three formulations were prepared in view of experimental and theoretical investigation of their drug release potential. The morphology of the film formulations, in terms of distribution of drug into the polymeric matrix and the nature of the dr ...

UNIV POLITEHNICA BUCHAREST, SCI BULL2020

Lactate enhancing compounds and uses thereof

Pierre Magistretti, Sylvain Eric Lengacher, Charles Léonard Finsterwald

Abstract of the invention: The present invention relates to new agents useful for stimulating release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prev ...

2020

Atomistic modeling of the solid-liquid interface of metals and alloys

Edoardo Baldi

Solidification is a phase transformation of utmost importance in material science, for it largely controls materials' microstructure on which a wide range of mechanical properties depends. Almost every human artifact undergoes a transformation that leads t ...

EPFL2020

A Unifying Representer Theorem for Inverse Problems and Machine Learning

Michaël Unser

Regularization addresses the ill-posedness of the training problem in machine learning or the reconstruction of a signal from a limited number of measurements. The method is applicable whenever the problem is formulated as an optimization task. The standar ...

2021

The Investigation of Flory-Huggins Interaction Parameters for Amorphous Solid Dispersion Across the Entire Temperature and Composition Range

Esther Amstad

Amorphous solid dispersion (ASD) is one of the most promising enabling formulations featuring significant water solubility and bioavailability enhancements for biopharmaceutical classification system (BCS) class II and IV drugs. An accurate thermodynamic u ...

2019