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Concept

Amniota

Publications associées (12)

Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations

Daria Korotkova

BackgroundIt is generally accepted that most evolutionary transformations at the phenotype level are associated either with rearrangements of genomic regulatory elements, which control the activity of gene networks, or with changes in the amino acid conten ...

2023

In vivo and ex vivo range of motion in the fire salamander Salamandra salamandra

Enrico Alexander Eberhard

Joint range of motion (RoM) analyses are fundamental to our understanding of how an animal moves throughout its ecosystem. Recent technological advances allow for more detailed quantification of this RoM (e.g. including interaction of degrees of freedom) b ...

2022

Mechanistic Understanding of Neurobehavioral Effects of Insecticides on the Larvae of Zebrafish (Danio rerio)

Sarah-Katharina Könemann

Due to conservation of neuronal functioning across phyla, molecular targets of insecticides are similar in insects and vertebrates. Insecticides thus pose a risk to aquatic vertebrates, such as fish, and potentially cause neurotoxic effects. Although these ...

EPFL2022

Reverse-engineering the locomotion of a stem amniote

Auke Ijspeert, Kamilo Andres Melo Becerra, Tomislav Horvat, Konstantinos Karakasiliotis

Reconstructing the locomotion of extinct vertebrates offers insights into their palaeobiology and helps to conceptualize major transitions in vertebrate evolution. However, estimating the locomotor behaviour of a fossil species remains a challenge because ...

2019

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

Didier Trono, Priscilla Turelli, Christian Axel Wandall Thorball, Julien Léonard Duc, Michaël Imbeault, Andrea Coluccio, Julien Paul André Pontis, Pierre-Yves Joseph Laurent Helleboid

Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFPs) are encoded in the hundreds by the genomes of higher vertebrates, and many act with the heterochromatin‐inducing KAP1 as repressors of transposable elements (TEs) during early embryogene ...

2019

Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

Pierre-Yves Joseph Laurent Helleboid

Transposable elements (TEs) are genetic units capable of spreading within the genomes of their host. TEs contribute a readily recognizable 45% of the human DNA, reflecting in part their co-option for some as source of protein-coding sequences, for others a ...

EPFL2019

The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units

Didier Trono, Julien Léonard Duc, Michaël Imbeault, Marco Cassano, Gabriela Ecco, Annamaria Kauzlaric

KRAB-containing poly-zinc finger proteins (KZFPs) constitute the largest family of transcription factors encoded by mammalian genomes, and growing evidence indicates that they fulfill functions critical to both embryonic development and maintenance of adul ...

Public Library of Science2017

KRAB zinc finger proteins

Didier Trono, Michaël Imbeault, Gabriela Ecco

Kruppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB domain and a C-terminal array of DNA-binding zinc fingers, they participate, toge ...

2017

Faster embryonic segmentation through elevated Delta-Notch signalling

Andrew Charles Oates

An important step in understanding biological rhythms is the control of period. A multicellular, rhythmic patterning system termed the segmentation clock is thought to govern the sequential production of the vertebrate embryo's body segments, the somites. ...

Nature Publishing Group2016

Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

Didier Trono, Priscilla Turelli, Sandra Eloise Kjeldsen, Julien Léonard Duc, Michaël Imbeault, Marco Cassano, Gabriela Ecco, Annamaria Kauzlaric, Andrea Coluccio

KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of transposable elements (TEs), which they repress with their cofactor KAP1 through histone and DNA methylation, a process thought to result in irreversible silencing. Using a ...

Cell Press - Elsevier2016

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis

Anne Grapin-Botton

BACKGROUND: Endoderm organ primordia become specified between gastrulation and gut tube folding in Amniotes. Although the requirement for RA signaling for the development of a few individual endoderm organs has been established a systematic assessment of i ...

Public Library of Science2009

Organisation of the spinal central pattern generators for locomotion in the salamander: biology and modelling

Auke Ijspeert

Among living tetrapods, salamanders are regarded as most closely resembling the first terrestrial vertebrates, and are therefore an interesting group in which the evolutionary changes in the locomotor behaviour from aquatic to terrestrial habitats can be i ...

2008