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Concept

Cardiac pacemaker

Publications associées (32)

Deep learning-based reduced order models in cardiac electrophysiology

Alfio Quarteroni, Andrea Manzoni, Luca Dede'

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies on the numerical approximation of coupled nonlinear dynamical systems. These systems describe the cardiac action potential, that is the polarization/depola ...

2020

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Nikolaos Stergiopoulos, Vasiliki Bikia, Bram Trachet, Georgios Rovas, Stamatia Zoi Pagoulatou, Mauro Ferraro

The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the ...

2021

Sequential Bone-Marrow Cell Delivery of VEGFA/S1P Improves Vascularization and Limits Adverse Cardiac Remodeling After Myocardial Infarction in Mice

Michele De Palma, Mario Leonardo Squadrito

Microvascular dysfunction and resulting tissue hypoxia is a major contributor to the pathogenesis and evolution of cardiovascular diseases (CVD). Diverse gene and cell therapies have been proposed to preserve the microvasculature or boost angiogenesis in C ...

MARY ANN LIEBERT, INC2019

Investigating the variability of cardiac pulse artifacts across heartbeats in simultaneous EEG-fMRI recordings: A 7T study

Rolf Gruetter, João Pedro Forjaco Jorge, Lucie Bréchet

Electroencephalography (EEG) recordings performed in magnetic resonance imaging (MRI) scanners are affected by complex artifacts caused by heart function, often termed pulse artifacts (PAs). PAs can strongly compromise EEG data quality, and remain an open ...

2019

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

Henry Markram, Rajnish Ranjan, Emmanuelle Logette, Enrico Scantamburlo, Michela Marani, Valérie Buchillier, Mirjia Herzog

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully sequenced decades ago, a comprehensive kinetic characterization of al ...

2019

Active contraction of cardiac cells: a reduced model for sarcomere dynamics with cooperative interactions

Alfio Quarteroni, Francesco Regazzoni, Luca Dede'

We propose a reduced ODE model for the mechanical activation of cardiac myofilaments, which is based on explicit spatial representation of nearest-neighbour interactions. Our model is derived from the cooperative Markov Chain model of Washio et al. (Cell M ...

SPRINGER HEIDELBERG2018

Estimating Left Ventricular Elastance from Aortic Flow Waveform, Ventricular Ejection Fraction, and Brachial Pressure: An In Silico Study

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou

Although left ventricular end-systolic elastance (E-es) serves as a major index of cardiac contractility, a widely-accepted noninvasive estimation of E-es does not exist. To overcome this limitation, we developed a two-step inverse method that allows for i ...

SPRINGER2018

Integrated Heart-Coupling multiscale and multiphysics models for the simulation of the cardiac function

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Toni Mikael Lassila, Simone Rossi

Mathematical modeling of the human heart and its function can expand our understanding of various cardiac diseases, which remain the most common cause of death in the developed world. Like other physiological systems, the heart can be understood as a compl ...

Elsevier Science Sa2017

Microfluidic system for monitoring of cardiac (H9C2) cell proliferation

Philippe Renaud

The paper presents the application of electrical impedance spectroscopy (EIS) analysis for investigation of cardiac cell (H9C2 – rat cardiomyoblast) proliferation after verapamil hydrochloride exposure. For this purpose, two different PDMS/glass microsyste ...

2017

Heart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and Alignment

Philippe Renaud

Lab-on-a-chip systems are increasingly used as tools for cultures and investigation of cardiac cells. In this article, we present how the geometry of microsystems and microenvironmental conditions (static and perfusion) influence the proliferation, morphol ...

Sage Publications Inc2017

Signal Processing Approaches for Cardio-Respiratory Biosignals with an Emphasis on Mobile Health Applications

Leila Mirmohamadsadeghi

We humans are constantly preoccupied with our health and physiological status. From precise measurements such as the 12-lead electrocardiograms recorded in hospitals, we have moved on to mobile acquisition devices, now as versatile as smart-watches and sma ...

EPFL2017

Dispositif et procédé pour l'évaluation de la contraction cellulaire

Boris Hinz

A method for assessing cell contraction includes adhering contractile cells to an oxidized and cellular adhesion activated surface of a biocompatible silicone elastomer film. The biocompatible silicone elastomer film allows the cells to contract and wrinkl ...

2017