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Concept

Ventricular hypertrophy

Publications associées (31)

Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities

Stamatia Zoi Pagoulatou

Ageing is a natural process that affects both the anatomical and functional properties of the cardiovascular system and alters the coupling characteristics between the heart and the aorta. These alterations may predispose the cardiovascular system in the d ...

EPFL2020

Ventricular response regularity in atrial fibrillation and its relationship to successful catheter ablation

Jean-Marc Vesin, Etienne Pruvot, Adrian Luca

Atrial rate is known to modulate ventricular response during atrial fibrillation (AF). The resulting pulse irregularity translates into widely varying inter-beat intervals (IBIs) extracted from recorded surface electrocardiogram (ECG) activity. In AF, the ...

IEEE2020

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Nikolaos Stergiopoulos, Vasiliki Bikia, Bram Trachet, Georgios Rovas, Stamatia Zoi Pagoulatou, Mauro Ferraro

The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the ...

2021

Implementation and Calibration of a Deep Neural Network to Predict Parameters of Left Ventricular Systolic Function Based on Pulmonary and Systemic Arterial Pressure Signals

Simone Deparis, Luca Pegolotti, Jean Bonnemain

The evaluation of cardiac contractility by the assessment of the ventricular systolic elastance function is clinically challenging and cannot be easily obtained at the bedside. In this work, we present a framework characterizing left ventricular systolic f ...

2020

Effect of fibre orientation and bulk modulus on the electromechanical modelling of human ventricles

Alfio Quarteroni, Antonello Gerbi

This work concerns the mathematical and numerical modeling of the heart. The aim is to enhance the understanding of the cardiac function in both physiological and pathological conditions. Along this road, a challenge arises from the multi-scale and multi-p ...

2020

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

Johan Auwerx

Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to hypertension, but specific mechanisms are unclear. The mitochondri ...

2020

Biophysically detailed mathematical models of multiscale cardiac active mechanics

Alfio Quarteroni, Francesco Regazzoni

Author summary Computer-based numerical simulations of the heart are increasingly assuming a recognized role in the context of computational medicine and cardiology. They are based on mathematical models describing the different physical phenomena occurrin ...

2020

Acute effects of transcatheter aortic valve replacement on the ventricular-aortic interaction

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas, Stamatia Zoi Pagoulatou

Transcatheter aortic valve replacement (TAVR) is increasingly used to treat severe aortic stenosis (AS) patients. However, little is known regarding the direct effect of TAVR on the ventricular-aortic interaction. In the present study, we aimed to investig ...

AMER PHYSIOLOGICAL SOC2020

Mapping Biological Current Densities With Ultrafast Acoustoelectric Imaging: Application to the Beating Rat Heart

Pierre-Marc Jean Marie Dansette

Ultrafast acoustoelectric imaging (UAI) is a novel method for the mapping of biological current densities, which may improve the diagnosis and monitoring of cardiac activation diseases such as arrhythmias. This paper evaluates the feasibility of performing ...

Institute of Electrical and Electronics Engineers2019

Nuclear receptor corepressor 1 represses cardiac hypertrophy

Johan Auwerx, Chao Li, Jun Wang, Yan Liu

The function of nuclear receptor corepressor 1 (NCoR1) in cardiomyocytes is unclear, and its physiological and pathological implications are unknown. Here, we found that cardiomyocyte-specific NCoR1 knockout (CMNKO) mice manifested cardiac hypertrophy at b ...

2019

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Alfio Quarteroni, Luca Dede', Simone Rossi, Luca Barbarotta

Models for cardiac mechanics require an activation mechanism properly representing the stress-strain relations in the contracting myocardium. In this paper, we propose a new activation model that accounts for the transmural heterogeneities observed in myoc ...

Wiley2018